Timing of labor induction after water breaks: study compares early vs. waiting

NCT ID NCT07261332

Disease control Sponsor: Laiba Qamar Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 88 pregnant women whose water broke before labor started, comparing those who got labor-inducing gel right away versus those who waited 24 hours. The goal was to see which approach led to shorter labor and more vaginal deliveries. The findings could help guide doctors on the best timing for induction.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: 0.5mg PGE2 gel
What this could lead to: If successful, this could help doctors decide the best timing for inducing labor in women with ruptured membranes, potentially leading to safer and more efficient deliveries.
What could go wrong: This is a small, completed study with only 88 participants, so results may not apply to all women. The intervention is a standard drug, so no major new breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

88 people

The number who actually took part.

Started

May 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. singleton pregnancy with cephalic presentation 2. gestational age between 37-41 weeks as calculated by last menstrual period date or early dating ultrasoumd 3. Spontaeous PROM as confirmed by history and sterile speculum examination 4. modified bishop score \<6 5. no detectable uterine contractions on admission 6. clear liqour and duration of PROM \<6 hours at admission Exclusion Criteria: 1. meconium stained liqour 2. patients with features of chorioamnionitis (fever , tachycardia, abdominal tendernessor foul smeeling vaginal discharge 3. maternal medical diseaseincluding prompt delivery or C section like severe preeeclampsia, renal or cardiac disease 4. presence of contraindications to labour such as placenta previa , Vasa previa,previous uterine surgery (e.g myomectomy ) that increases the risk of uterine rupture , previous C section 5. history of antepartum hemorrhage 6. Moderate to severe IUGR as diagnosed on ultrasound and doppler studies

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Conditions

The condition(s) this trial relates to.

Fetal Membranes, Premature Rupture obstetric disorder pregnancy disorder preterm premature rupture of the membranes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Induction of labor Labor (obstetrics)--complications Prelabor rupture of membranes

Timing of labor induction after water breaks: study compares early vs. waiting

What the study statuses mean