Atrial fibrillation

Researchers at Ege University are testing a mobile phone program called m-BAFY that helps people with atrial fibrillation manage their condition at home. The app lets patients record symptoms and vital signs, sends personalized feedback, and provides guideline-based information o…

This trial tests whether people with atrial fibrillation who had a stent placed more than a year ago can safely switch from two blood thinners to just one. Participants receive either a single anticoagulant or the same anticoagulant plus clopidogrel for two years. Researchers tra…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This study looks at whether doing two procedures at once—pulsed field ablation (FARAPULSE) to fix irregular heartbeats and implanting a Watchman device to close off a part of the heart where clots form—is as safe as doing them separately. About 120 people with atrial fibrillation…

This trial tests whether a wearable ECG patch called MEMO Patch Plus can detect clinically significant arrhythmias in adults hospitalized with acute heart failure. Participants wear the patch for up to 14 days in the hospital and again for up to 14 days after discharge. The study…

This observational study is tracking 678 people with atrial fibrillation who are getting a Watchman device implanted to close off the left atrial appendage and reduce stroke risk. The study focuses on centers where a single doctor performs eight or more of these procedures in one…

This study looks at whether a predefined plan to pause and restart blood thinners (factor Xa inhibitors) around minor procedures—like dental work, cataract surgery, or routine endoscopy—can reduce bleeding in people with atrial fibrillation. It follows 2,500 adults who take rivar…

This observational study is evaluating the safety and effectiveness of apixaban, a blood thinner, in frail Korean patients with atrial fibrillation (an irregular heartbeat) who are at high risk for stroke and bleeding. The study will follow about 2,000 patients who are older, hav…

This trial tests whether using cryoballoon ablation as the first treatment for persistent atrial fibrillation (AF) is more effective and safer than starting with anti-arrhythmic drugs. Adults aged 18-75 with symptomatic persistent AF and a structurally normal heart are eligible. …

This pilot study tested whether community pharmacists can manage blood thinner therapy for older adults (60+) with atrial fibrillation who are at high risk for stroke but not on optimal treatment. Fourteen participants received pharmacist-led care for 3 months, then were followed…

This early-stage trial is testing an investigational drug called SHR-2004, given as multiple injections under the skin, in about 10 adults with atrial fibrillation (an irregular heartbeat). The main goal is to see if the drug is safe and tolerable, and to learn how it moves throu…

This trial tests whether a newer type of heart ablation, called pulsed-field ablation, can effectively isolate the pulmonary veins in people with paroxysmal atrial fibrillation while using very little or no X-ray guidance. The procedure uses the Farapulse system with a special ma…

This study tested a device called iCLAS™ that uses extreme cold to destroy tiny areas of heart tissue causing persistent atrial fibrillation (AFib). 215 adults with AFib lasting more than 7 days but less than a year received the procedure. Researchers tracked safety issues like h…

This study tested a new device called the Volt PFA System, which uses pulsed field ablation to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 392 people with symptomatic AF that didn't respond to medication. The goal was to see if the procedur…

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. 292 adults with drug-resistant AF took part. The goal was to see if the new method is faster, safer, and more effectiv…

This study tests a device that freezes small areas of heart tissue to treat paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. About 200 people with AFib that hasn't responded to medication will receive the procedure. Researchers will track safe…

This trial tests whether a newer cryoballoon device, PolarX, works as well as the standard Arctic Front device for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 200 people having their first pulmonary vein isolation procedure will be randomly assi…

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study investigates whether dapagliflozin, a drug typically used for diabetes, can improve the structure and function of the heart's left atrium in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). Researchers will measure changes…

This trial investigates whether a one-year, app-supported home exercise program can improve quality of life and reduce the time spent in atrial fibrillation (AF) compared to usual care. Participants have paroxysmal or persistent AF, are in sinus rhythm at the start, and use a sma…

This trial tests whether a special cooling probe placed in the esophagus can protect it from heat damage during a common heart procedure for atrial fibrillation (AF). AF is a heart rhythm disorder that can cause serious symptoms, and ablation uses heat to fix it, but the esophagu…

This study tests whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban reduce the risk of stroke, major bleeding, or heart-related death in people with atrial fibrillation who have an intermediate stroke risk (CHA2DS2-VASc score of 1 in men or 2 in women). About…

This study looked at 9 people with atrial fibrillation (AFib) that came back after an initial cryoballoon ablation. It compared two repeat ablation methods: another cryoballoon procedure versus radiofrequency ablation guided by a high-fidelity mapping system (Rhythmia). Participa…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This completed study tested a new catheter and generator system designed to treat paroxysmal atrial fibrillation (AFib) — a common heart rhythm problem. The device uses pulsed field ablation (PFA) to target and destroy tiny areas of heart tissue causing the irregular rhythm. 188 …

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested whether using a 3D electroanatomic mapping system (FARAVIEW) during pulsed field ablation helps create more precise lesions in the pulmonary veins of people with atrial fibrillation. Thirty-two participants were randomly assigned to receive ablation with or with…

This study tested whether a smartphone app that reminds patients to take their medication can improve how consistently people with atrial fibrillation take their blood thinner (rivaroxaban). Over 600 adults with AF and other health issues like high blood pressure or diabetes used…

This study tested whether catheter ablation (a procedure to fix irregular heart rhythm) is better than standard rate-control medication for people with both atrial fibrillation and heart failure. Over 400 participants were randomly assigned to either ablation or medication. The m…

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and at…

This study looked at 200 people with both heart failure and permanent atrial fibrillation. Participants received either a standard defibrillator (ICD) or one that also paces both lower heart chambers (CRT/ICD). The goal was to see if the extra pacing reduces heart size and improv…

This study tested whether low doses of digoxin, an old and cheap heart drug, can reduce hospitalizations and death in 982 heart failure patients. Participants received either digoxin or a placebo pill. The goal is to see if keeping digoxin levels low in the blood improves outcome…

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…

This study tested two new devices that use energy pulses to treat persistent atrial fibrillation (a type of irregular heartbeat). 89 adults who had not responded to medication received a heart ablation procedure. The goal was to see if the devices are safe and can stop abnormal h…

This early study tested whether placing a thin layer of human amniotic membrane on the heart during bypass surgery could reduce inflammation and prevent post-operative atrial fibrillation (an irregular heartbeat). Twenty-seven patients were randomly assigned to receive either the…

This study tested a systematic 12-step workflow for a newer type of heart ablation (pulsed-field ablation) in 118 adults with atrial fibrillation. The goal was to see if this approach could better isolate the pulmonary veins and reduce the chance of the heart rhythm problem retur…

This study tested a new device called the OMNYPULSE catheter with the TRUPULSE generator to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal was to see if it is safe and effective at isolating the veins that carry blood from the lungs to the heart. 1…

This study tested whether removing the ligament of Marshall during coronary artery bypass surgery could prevent a common complication: atrial fibrillation. 220 high-risk patients were randomly assigned to get the extra procedure or standard surgery alone. The goal was to see if t…

This study tested whether using a 3D-printed model of a heart chamber helps doctors better plan a procedure to close off a small pouch in the heart. This pouch, called the left atrial appendage, is a common source of blood clots that can cause stroke in people with atrial fibrill…

This study tested a new device that uses short electrical pulses to treat a type of irregular heartbeat called paroxysmal atrial fibrillation. Ten patients received the procedure to see if it was safe and could stop the heart rhythm problem for at least 12 months. The goal was to…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study followed 364 people with paroxysmal atrial fibrillation (a type of irregular heartbeat) who had already received ablation treatment in a previous trial. Researchers compared a newer pulsed field ablation system with traditional thermal ablation to see how well each met…

This study tested a device called Amplatzer Amulet that closes a small pouch in the heart (left atrial appendage) in people with atrial fibrillation. The goal was to see if it safely reduces stroke risk without long-term blood thinners. 104 adults at high stroke risk took part ac…

This study compares two types of ablation (pulsed-field vs cryoballoon) for treating atrial fibrillation in people with heart failure and reduced pumping function. Researchers looked back at 700 patients who had their first ablation to see which method works better and is safer. …

This study tests a device called the Farawave catheter, which uses electrical pulses to destroy heart tissue causing long-standing atrial fibrillation. Twenty adults with this condition for over a year will undergo the procedure. The goal is to see if it stops abnormal heart rhyt…

This study looked at whether a combination drug (sacubitril/valsartan) can stop atrial fibrillation from returning after a heart procedure called catheter ablation. The study included 320 older adults (ages 55-80) with high blood pressure and atrial fibrillation. Participants too…

This study tested whether a generic version of dronedarone hydrochloride tablets works the same as the brand-name drug MULTAQ in healthy adults. Fifty-one healthy male volunteers took a single dose of either the generic or brand drug under fasting conditions. The results showed t…

This study tested a device called the Lariat to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who cannot take blood thinners. The goal was to reduce the risk of stroke. Nine participants were enrolled, and the study measured h…

This study tested a new system that uses electrical pulses to treat a type of irregular heartbeat called paroxysmal atrial fibrillation (AF). The system includes a special catheter and generator designed to safely and effectively stop the faulty signals causing the condition. 150…

This study tested a new type of catheter (a thin tube) that uses heat to destroy tiny areas of heart tissue causing irregular heartbeats in people with paroxysmal atrial fibrillation (AFib). The catheter has a cooling system to prevent overheating. The trial involved 415 particip…

This study looked at whether rebamipide, a stomach-protecting drug, can prevent bleeding and ulcers in people with atrial fibrillation who take blood thinners (DOACs). 210 adults were randomly assigned to receive rebamipide, pantoprazole, or both for 24 weeks. The goal was to see…

This study tested a voltage-guided stepwise ablation strategy against the standard circumferential approach for treating atrial fibrillation. 130 adults with AF undergoing their first catheter ablation were randomly assigned to one of the two methods. The goal was to see if the s…

This study looked at whether using a CPAP machine at night can reduce episodes of atrial fibrillation (a type of irregular heartbeat) in people who also have obstructive sleep apnea. Twenty-five adults with both conditions were enrolled. Half used CPAP while the other half were o…

This completed study tested a multi-discipline care program for 343 adults with atrial fibrillation. Led by an electrophysiologist, the team aimed to uncover hidden risk factors and improve treatment. Researchers monitored AF burden and major cardiovascular events like stroke and…

This early-phase trial tested a single dose of the investigational drug THRV-1268 in 16 healthy obese adults to see if it is safe and tolerable. The drug is being developed as a potential treatment for heart failure. The study did not test effectiveness, only safety and how the d…

This study tested a new device that uses electrical pulses to treat a type of irregular heartbeat called paroxysmal atrial fibrillation. 142 people who had not been helped by standard medications took part. The goal was to see if the procedure could keep their heart rhythm normal…

This study tested whether a stellate ganglion block (a nerve injection) before coronary artery bypass surgery can prevent new atrial fibrillation, a common complication. 108 patients were included. The approach aims to calm the nervous system and reduce inflammation. Results coul…

This study tested the FARAPULSE system, a device that uses short electrical pulses to destroy small areas of heart tissue causing abnormal rhythms in people with persistent atrial fibrillation (AFib). The trial enrolled 669 adults with drug-resistant, symptomatic persistent AFib.…

This study tested a new tool called VISITAG that helps doctors track where they apply heat during a heart procedure for atrial fibrillation (AFib). The goal was to see if it makes the procedure safer and more effective at preventing irregular heartbeats for a year. 200 adults hav…

This study tested a procedure to close a small pouch in the heart (left atrial appendage) in people with atrial fibrillation who are at high risk for both stroke and bleeding. The goal was to see if this procedure works better than standard blood-thinning medications at preventin…

This study tested a single hybrid procedure that combines keyhole surgery with a catheter-based approach to treat complex atrial fibrillation (AF) in 12 patients. The goal was to see if this combined method could completely isolate the abnormal electrical signals in the heart. Th…

This study tested a special catheter and generator system to treat people with paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. The goal was to safely isolate the veins that trigger AFib and restore normal rhythm. 135 participants were treated…

This study looked at how tissue covers the WATCHMAN FLX Pro device after it is placed in the heart to prevent strokes in people with atrial fibrillation. 43 participants received the implant and had follow-up CT scans and echocardiograms to check for any thickening on the device …

This study tested a new approach for repeat catheter ablation in people with atrial fibrillation (AF) whose symptoms returned after a previous ablation. Doctors used a special software algorithm (VX1) to guide the procedure. The study included 96 adults and measured how many stay…

This study tested a two-part approach to prevent a common complication called atrial fibrillation after heart surgery. About 242 people having coronary bypass surgery received a preventive dose of the drug amiodarone and a surgical technique called posterior pericardiotomy. The g…

This study looked at how safe and effective a freezing treatment (cryoablation) is for people with a type of irregular heartbeat called paroxysmal atrial fibrillation (AFib). The treatment uses a device called POLARx to freeze heart tissue and stop the faulty signals causing AFib…

This study looked at whether stopping coffee helps prevent atrial fibrillation (AFib) from returning after a heart shock treatment called cardioversion. Two hundred coffee drinkers with AFib were randomly assigned to either keep drinking coffee or avoid it for six months. Researc…

This study tested a procedure called left atrial appendage occlusion (LAAO) against standard blood-thinning medications in 81 people with atrial fibrillation who were also getting a new heart valve (TAVI). The goal was to see if LAAO could prevent strokes and bleeding better than…

This pilot study tested a procedure to close the left atrial appendage—a small pouch in the heart where clots often form—in 58 patients with atrial fibrillation who had a prior brain bleed and cannot take standard blood thinners. The goal was to see if this approach could reduce …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at 320 adults with paroxysmal atrial fibrillation (a type of irregular heartbeat) to compare two cryoballoon ablation techniques: freezing only the pulmonary veins versus freezing both the veins and the back wall of the heart's left upper chamber. The goal was t…

This study tested whether adding ablation of the left atrial posterior wall to standard pulmonary vein isolation reduces the return of atrial fibrillation in people with persistent AF. A total of 110 adults having their first catheter ablation took part. The goal was to see if th…

This study tracked 949 patients with non-valvular atrial fibrillation who received the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to reduce stroke risk. The goal was to see how well the device works in everyday medical practice, focusing on safet…

This study tested a device called the DiamondTemp system, which uses heat energy to destroy tiny areas of heart tissue causing irregular heartbeats in people with persistent atrial fibrillation. 376 adults with drug-resistant symptoms took part. The goal was to see if the procedu…

This phase 3 trial tested a special balloon catheter that uses radiofrequency energy to destroy tiny areas of heart tissue causing irregular heartbeats in people with symptomatic paroxysmal atrial fibrillation. The study enrolled 397 adults who had not responded to medication. Th…

This study tested whether adding a personalized, computer-model-guided ablation (OPTIMA) to the standard pulmonary vein isolation (PVI) procedure improves outcomes for people with persistent atrial fibrillation. 67 participants were randomly assigned to receive either PVI alone o…

This trial tested two blood thinners—rivaroxaban (Xarelto) and aspirin—in over 1,200 people with atrial fibrillation who had a successful ablation procedure. The goal was to see which one better prevents strokes and silent brain clots. Participants were followed for three years w…

This study tested whether sending mild electrical pulses just under the skin could help control heart rate in people with atrial fibrillation (AFib). 46 adults with symptomatic paroxysmal AFib who didn't respond to standard drugs were given a device implant. For two weeks, some r…

This study looked at whether metformin, a drug usually used for diabetes, can help prevent atrial fibrillation (an irregular heartbeat) from coming back after a standard procedure called catheter ablation. About 117 non-diabetic adults with a higher body weight took metformin or …

This study tested two different defibrillator waveforms—Zoll's 200J rectilinear biphasic shock and Lifepak's 360J biphasic truncated exponential shock—to see which restores normal heart rhythm better in people with atrial fibrillation. Over 500 adults were randomly assigned to re…

This completed study in Algeria followed 398 adults with atrial fibrillation who were taking the blood thinner Trombix (Rivaroxaban). The goal was to see how safe and effective the drug is in everyday medical practice, and how it affects quality of life. Researchers tracked serio…

This study tested whether a device called WATCHMAN FLX, which closes a small pouch in the heart, is a good alternative to blood thinners for preventing strokes in people with atrial fibrillation (AF) after a heart procedure called ablation. About 1,600 high-risk patients were enr…

This study tested two non-thermal ablation systems in 100 people with paroxysmal atrial fibrillation to see which works better and is safer. Patients were randomly assigned to one of the two devices, and their heart rhythms were monitored for a year. The goal was to find out whic…

This study tested a new mapping feature (FARAVIEW™) used with a pulsed field ablation catheter (FARAWAVE NAV™) to treat atrial fibrillation. Fifty patients with symptomatic AFib that didn't respond to medication were included. The goal was to see how well doctors could isolate th…

This study compared two treatments for persistent atrial fibrillation (an irregular heartbeat): cryoablation (freezing tiny areas of heart tissue) and antiarrhythmic drugs. 196 patients were randomly assigned to one treatment and monitored for over a year. The goal was to see whi…

This study tested a device called the Laminar Left Atrial Appendage Closure System in 29 people with atrial fibrillation who cannot take blood thinners. The device is implanted to seal off a small pouch in the heart where clots often form. The goal was to see if it is safe and ef…

This study tested two ways to treat persistent atrial fibrillation (a type of irregular heartbeat) using catheter ablation. In one group, doctors aimed to stop the abnormal rhythm during the procedure. In the other, they followed a preset plan and used electrical shock if needed.…

This study tested a procedure called cryoballoon ablation in 1,420 people with atrial fibrillation (an irregular heartbeat) and severe heart failure. The goal was to see if freezing the veins that trigger the irregular rhythm could reduce recurrence of the heart rhythm problem an…

This study tested whether a tailored ablation approach, which targets specific abnormal areas in the heart, works better than the standard anatomical ablation for people with persistent atrial fibrillation (AFib). 377 adults with AFib that didn't respond to medication were includ…

This study tested a new catheter system that uses pulsed field energy to treat atrial fibrillation and related arrhythmias. In 141 patients, doctors used the VARIPULSE catheter with a 3D mapping system to destroy the heart tissue causing the irregular rhythm. The goal was to see …

Researchers are testing whether a wearable armband called HeartWatch can record heart rhythm data as well as standard Holter and event monitors. Adults who need extended heart rhythm monitoring wear the armband alongside a standard device for up to three days. The study checks wh…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This trial tests whether a wearable device called MobiCARE, worn for 7 days, can spot undiagnosed atrial fibrillation—an irregular heartbeat that raises stroke risk—in people who have had a routine health check-up. The study enrolls adults with stroke risk factors, such as high b…

This study tested whether wearing a small heart monitor (MEMO Patch PLUS) for 8 to 14 days finds more cases of hidden atrial fibrillation than wearing it for just 1 day. About 1,000 adults aged 75 or older (or with other stroke risk factors) wore the patch. The goal was to see if…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested whether two wearable devices—the Apple Watch and the Skylab CART-I ring—can accurately detect atrial fibrillation and other irregular heart rhythms compared to the standard 12-lead ECG. Researchers recruited 500 adults from UK cardiology clinics. Each participan…

This study tested whether a simple scoring system (ATE score) can safely rule out dangerous blood clots in the heart before a procedure for atrial fibrillation. Over 3,000 adults participated. The goal was to see if the score could replace a more uncomfortable ultrasound test, po…

This study tested whether a Withings device (BeamO with ECG app) can accurately detect atrial fibrillation, a common heart rhythm problem. Over 370 adults each had a 30-second ECG with the device and a standard 12-lead ECG for comparison. The goal was to see how well the device i…

This study tested a wearable heart monitor called Cardea SOLO against a standard 12-lead EKG to see if it could better detect paroxysmal atrial fibrillation (a temporary irregular heartbeat) in people who had a stroke of unknown cause and have an enlarged heart. 257 participants …

This study tested a new device called Masimo INVSENSOR00057 that records a single-lead ECG, similar to a standard lead I. Researchers compared its heart rate and atrial fibrillation detection against standard measurements in 365 adults, including healthy people and those with AFi…

This study tested whether an artificial intelligence algorithm (ZywieAI) can accurately analyze heart rhythm data collected from a wearable sensor (ZywieZ3) worn for 24 hours. The sensor was placed in non-traditional positions on the chest. Researchers compared the AI's findings …

This study tested whether an Apple Watch can detect atrial fibrillation (a heart rhythm problem) faster than usual methods in people aged 65 and older with high stroke risk. Over 400 participants wore the watch, which uses light sensors and an ECG to check heart rhythm. The goal …

This study tests if a nerve block called a stellate ganglion block can lower the chance of developing atrial fibrillation (a fast, irregular heartbeat) after heart surgery. About 220 adults having valve or bypass surgery will receive either the nerve block or a placebo. The goal …

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study tested whether a low-dose infusion of landiolol, a short-acting beta-blocker, could prevent atrial fibrillation in 400 non-Asian patients after cardiac surgery. Participants received either landiolol or a placebo for up to 48 hours after surgery. The goal was to see if…

This study tested whether making a small cut in the sac around the heart (posterior pericardiotomy) during open-heart surgery can prevent a common complication called atrial fibrillation. 210 adults having elective heart surgery in Yemen were randomly assigned to receive either t…

Researchers at the University of Minnesota are testing whether exercise reduces the amount of time people spend in atrial fibrillation. The trial enrolls 60 sedentary adults aged 18 to 65 who have symptomatic, non-permanent AF. Participants are assigned to high-intensity interval…

Researchers are testing whether a pacemaker setting called closed-loop stimulation helps the heart rate rise more naturally during mental and physical stress compared with standard accelerometer-based pacing. The study includes adults with permanent atrial fibrillation, chronotro…

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This trial tests whether a structured self-management program, based on the Common-Sense Model of Self-Regulation, can help people recover after a procedure to treat atrial fibrillation (an irregular heartbeat). Participants will be randomly assigned to receive either routine nur…

This study tested whether an 8-week cardiac rehabilitation program using a stationary bike could improve cardiorespiratory fitness in 20 adults with atrial fibrillation. Participants exercised for 6 minutes, three times a week. The goal was to see if exercise capacity could incre…

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study tested whether a commercial meal replacement weight loss programme could reduce atrial fibrillation (AF) symptoms in overweight adults aged 60-85 with persistent AF. 119 participants were randomly assigned to either the weight loss programme or usual care for 32-36 wee…

This study tested whether showing patients with atrial fibrillation (AF) simple visual charts of common post-ablation symptoms could help them decide more confidently about undergoing the procedure. 75 adults with symptomatic AF who were considering catheter ablation used these d…

This study tested three different drug combinations to keep patients comfortable and still during a heart procedure called pulsed field ablation for atrial fibrillation. 240 adults were randomly assigned to one of three sedation groups. The goal was to see which method achieved t…

This study tested whether giving calcium before the drug diltiazem can prevent a sudden drop in blood pressure in people with a fast heart rate due to atrial fibrillation or flutter. 92 adults took part. The goal was to make the treatment safer and more comfortable.

This study tested a short mindfulness and exposure therapy program in 13 adults with atrial fibrillation who also had high anxiety sensitivity. The goal was to see if the therapy could reduce heart-related anxiety, symptom burden, and AFib episodes. Participants attended 4-5 indi…

This study tested a remote magnetic catheter ablation technique for treating atrial fibrillation, a common heart rhythm problem. Researchers followed 804 patients to see how safe the procedure was, how much radiation it used, and how well it worked. The goal was to improve routin…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study examines whether closing the left atrial appendage with a device called AMULET changes how well the heart relaxes. It includes 100 adults with atrial fibrillation who are at high risk for stroke but cannot take blood thinners. Researchers measure heart function using u…

This study looks at medical records from France to see how doctors prescribe blood thinners to people with atrial fibrillation (an irregular heartbeat) who also have a high risk of stomach bleeding. The goal is to understand which treatments are used and how often serious bleedin…

This pilot study looked at whether it's possible to run a larger trial comparing two types of exercise—moderate steady exercise and high-intensity interval training—on symptoms of atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 25 men and women with …

This study follows 340 people with atrial fibrillation who are having their first ablation procedure. Researchers will track heart rhythm using remote monitoring, along with imaging and blood tests, to find which factors—like patient health, heart structure, or electrical signals…

This study looked at 70 people aged 75 and older with atrial fibrillation who were taking a Xaban blood thinner (dabigatran, rivaroxaban, or apixaban) during an unplanned hospital stay. Researchers wanted to see if certain clinical or lab factors were linked to higher drug levels…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This study enrolled 91 people with atrial fibrillation to see if computer simulations can identify the main electrical problem causing their irregular heartbeat. Participants had heart imaging, mapping, and symptom tracking before and after a standard ablation procedure. The goal…

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This study looked at 636 older Italian patients with a type of irregular heartbeat called non-valvular atrial fibrillation (NVAF). Researchers wanted to understand why some patients start taking blood thinners and others do not, and how long they stay on their treatment. The goal…

This study looks at 250 people with atrial fibrillation who are having a hybrid ablation procedure. Researchers want to find out which factors—like clinical history, blood markers, and genetics—are linked to the procedure failing. The goal is to create a risk profile that helps d…

This study tested a new catheter designed to measure the heart's electrical signals in people with irregular heartbeats (atrial fibrillation, ventricular fibrillation, or junctional tachycardia). Researchers enrolled 42 adults to see if the device could better identify abnormal e…

This study collected medical and social information from 111 patients having their first ablation for atrial fibrillation, a common heart rhythm problem. Researchers wanted to understand how factors like income, education, location, and ethnicity might affect who receives this tr…

This study looked at how well a new heart monitor (Assert-IQ) detects atrial fibrillation (an irregular heartbeat) in people who have had a heart ablation procedure. 151 participants wore the monitor as part of their normal care. Researchers compared the monitor's readings to a s…

This study gathered information from routine medical care for 198 adults with atrial fibrillation who had a prior procedure to close a small heart pouch (left atrial appendage occlusion) and later needed a heart ablation. Researchers looked at patient details, procedure steps, bl…

This study aimed to create a new questionnaire that measures how atrial fibrillation (AF) affects a person's quality of life. Researchers worked with 206 adults who have AF to develop and test this tool. The goal was to better understand the real-world impact of AF beyond just me…

This study looked at 468 Italian adults who take blood thinners (anticoagulants) to understand their health knowledge, quality of life, and confidence in managing their condition. Researchers used questionnaires to measure these factors and see how they relate to age, education, …

This study looked at 155 people with early-onset atrial fibrillation to see if genetic testing can help doctors choose better treatments. Participants had heart imaging and ECG tests to find hidden heart muscle or rhythm disorders. The goal is to learn how genetics influence the …

This study tracked 1,826 people who received a small implantable heart monitor (Confirm Rx) to check for irregular heartbeats. Over 12 months, researchers recorded how often the device caused serious problems and how well it worked in daily life. The goal was to see if the monito…

This study looked at 321 people with pacemakers or heart monitors who had short, symptomless episodes of atrial fibrillation (silent AF). Researchers measured certain proteins in the blood to see if they could predict who might later have a stroke or other heart problems. The goa…

This study looked at 200 people with atrial fibrillation to see if treatments like catheter ablation or exercise training change levels of a brain chemical called BDNF. Researchers also checked if these changes relate to mood and quality of life. The goal was to gather knowledge,…

This study tested a 12-week virtual education program for primary care providers in North Carolina to improve how they manage atrial fibrillation (AFib). 70 providers joined online sessions to learn about AFib care and EKG interpretation. Researchers measured changes in provider …

This study tested a six-session virtual education program called 'AF at Home' for adults with atrial fibrillation. Participants attended Zoom classes over three weeks to learn about self-monitoring and managing their condition. The goal was to see if the program improved quality …

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This study looked at whether sending alerts to pharmacists instead of doctors helps improve how blood thinners (anticoagulants) are prescribed. Researchers tested two types of alerts with 306 healthcare providers. The goal was to see which method leads to faster and safer prescri…

This study compared two heart-mapping systems, RHYTHMIA and CARTO, in 49 adults undergoing a repeat procedure for atrial fibrillation (AF). The goal was to see which system better finds gaps from previous ablations. The study did not test a new treatment but aimed to improve unde…

This study looked at 44 people with persistent atrial fibrillation who had a second heart procedure 2 months after their first ablation. Doctors checked for reconnections in the pulmonary veins and treated them again to see if this improves outcomes. The goal was to better unders…

This study looked at how the blood thinner edoxaban behaves in 150 Chinese adults with non-valvular atrial fibrillation (an irregular heartbeat). The goal was to see if current dosing models fit Chinese patients and to create a more personalized dosing plan to improve effectivene…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This completed study tracked 832 heart attack patients in China who developed new-onset atrial fibrillation during their hospital stay. Researchers used continuous heart monitoring to see how the amount of AFib affected risks like death, another heart attack, or heart failure. Th…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study developed an artificial intelligence system that combines patient medical records and doctors' notes to predict whether atrial fibrillation (an irregular heartbeat) will return after a common treatment called ablation. Researchers analyzed data from over 2,500 patients…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study followed 167 people with atrial fibrillation or flutter who had a catheter ablation procedure. Researchers measured changes in stroke and bleeding risk scores before and 3, 6, and 12 months after ablation. They also compared different monitoring methods, including impl…

This study looked at 172 people with atrial fibrillation who had a heart procedure guided by a special ultrasound. Researchers found a common harmless imaging artifact, called the 'Floating Lotus' sign, that can look like a dangerous blood clot. By learning to tell the difference…

This study looked at 91 Chinese patients with atrial fibrillation who had a stroke while taking blood thinners (NOACs). The goal was to understand why these strokes happen and whether not taking the medication as prescribed played a role. Researchers hope this knowledge will help…

This study measured the amount of common blood thinners (dabigatran, apixaban, and rivaroxaban) in the blood of 308 Chinese adults with atrial fibrillation who had been taking the medication for at least 3 months. The goal was to establish normal reference ranges for these drugs …

This study tested a special breathing technique during atrial fibrillation ablation to see if it reduces catheter movement. Fifty-two adults with atrial fibrillation were given both standard and high-frequency, low-volume ventilation during their procedure. The goal was to see if…

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study tested whether a generic version of dronedarone hydrochloride (400 mg tablets) works the same as the brand-name drug MULTAQ in 48 healthy Chinese adults. Participants took a single dose under fed conditions, and researchers measured drug levels in the blood to check fo…

This study tested two heart monitoring methods in 516 people who had a transient ischemic attack (TIA or mini-stroke). The goal was to see which method better detects hidden atrial fibrillation, a heart rhythm problem that raises stroke risk. Participants received either a small …

This study tested a new imaging system called VERAFEYE in 18 people already scheduled for standard heart procedures like ablation or closure. Doctors used the device during the procedure and gave feedback via a questionnaire. The goal was to gather information to improve the syst…

This study tested whether a computer program (Clinical Decision Support System) helps doctors follow official treatment guidelines for patients with both high blood pressure and atrial fibrillation (an irregular heartbeat). Researchers compared clinics using the program to those …

This completed study tested a new algorithm that automatically measures the cycle length and complexity of atrial fibrillation (AF) signals during a heart ablation procedure. Researchers collected data from 21 people with persistent AF undergoing ablation. The goal was to see if …

This study looked at 9 people with persistent atrial fibrillation (a type of irregular heartbeat) to see if different treatments affect thinking skills differently. Participants were given standard care and had their cognitive function measured with questionnaires and brain scans…

This study aimed to find the best marker for measuring how well heart rate is controlled in people with atrial fibrillation. Researchers tested 13 adults using exercise tests with different doses of heart rate medication. The goal was to see which marker best reflects rate contro…

This study compared two methods for a key step in atrial fibrillation ablation—puncturing the wall between heart chambers—without using any X-rays. Both techniques used ultrasound instead. The trial involved 28 patients and measured how long each method took, whether X-rays were …

This study looked at 80 people having a heart procedure called ablation to treat irregular heartbeats. Doctors wanted to see if a CT scan could accurately show the location of a nerve near the heart that can be accidentally injured. They compared the CT images with a standard met…

This completed study analyzed data from over 2 million people in France with atrial fibrillation (an irregular heart rhythm) to compare outcomes between those who took blood thinners and those who did not. Researchers looked at rates of stroke, major bleeding, and death between 2…

This study looked at 116 people with paroxysmal atrial fibrillation (AFib) who were scheduled for a heart ablation procedure. Researchers measured baroreflex sensitivity—a non-invasive test of the autonomic nervous system—before the procedure. They wanted to see if this measureme…

This study gathered information from 100 people undergoing a standard heart procedure called left atrial appendage closure. Researchers used the data to test a software tool that measures heart structures from echocardiograms. No new treatments or procedures were given—only routi…

This study looked at 175 adults with atrial fibrillation who had radiofrequency ablation. Researchers wanted to see if a special map of the heart's electrical signals (called an isochron map) could predict whether patients would stay free of atrial fibrillation 18 months later. T…

This study tested a new computer algorithm that analyzes heart signals during a procedure called ablation for persistent atrial fibrillation (a type of irregular heartbeat). The goal was to see if the system could collect and process these signals to help doctors better understan…

This pilot study involved 9 people with atrial fibrillation undergoing a first-time pulsed field ablation procedure. Researchers collected heart signal data to test a new algorithm that automatically measures local electrical activity. The goal was to see if the automated measure…

This study tested a larger 31 mm cryoballoon in 20 patients with paroxysmal atrial fibrillation to see how much heart tissue it could freeze. Researchers used 3D maps before and after the procedure to measure the size of the treated area. The goal was to gather data to improve fu…

This study looked at over 12,500 people in Korea with atrial fibrillation (an irregular heartbeat) to see how their condition and health outcomes changed over time. Researchers used existing hospital and national insurance records, not new patient visits. The goal was to better u…

This study looked at 17 adults with persistent atrial fibrillation (a long-lasting heart rhythm problem) to find specific areas in the heart that may keep the condition going. Researchers used special mapping to identify stable high-frequency electrical signals. The goal was to b…

This study looked at how safe and effective the blood thinner edoxaban is for preventing strokes in people aged 80 or older with a common heart rhythm problem called atrial fibrillation. Researchers followed over 1,200 patients in Korea who were already prescribed edoxaban by the…

This study looked at 40 adults with atrial fibrillation (an irregular heartbeat) to compare two ways of performing a common treatment called pulmonary vein isolation. One method uses advanced 3D heart mapping, while the other relies on standard X-ray guidance. The goal was to see…

This completed study looked at nearly 1,000 people aged 80 and older with atrial fibrillation (an irregular heartbeat) who were newly prescribed the blood thinner apixaban. Researchers tracked bleeding events and how well the dose matched each patient's needs. The goal was to gat…

This study followed 50 atrial fibrillation patients for 12 months to see if advanced heart imaging and ECG tests can predict whether the drug flecainide will keep their heart in normal rhythm. Researchers collected data during four clinic visits and analyzed it against outcomes l…

This completed study enrolled 164 adults with chronic heart failure, some also with permanent atrial fibrillation. Researchers measured blood markers of inflammation and certain microRNAs (genetic molecules) and used echocardiograms to look at heart structure. The goal was to und…