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New hope for stomach protection in heart patients on blood thinners

NCT ID NCT07354230

Disease control Sponsor: Pirogov Russian National Research Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether rebamipide, a stomach-protecting drug, can prevent bleeding and ulcers in people with atrial fibrillation who take blood thinners (DOACs). 210 adults were randomly assigned to receive rebamipide, pantoprazole, or both for 24 weeks. The goal was to see which approach best prevents stomach problems like bleeding or severe indigestion.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

210 people

The number who actually took part.

Started

Jan 2022

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women from 18 till 80 years old * Patients with atrial fibrillation (AF) and a moderate or high risk of thromboembolic complications (\>=1 point in men and \>=2 points in women according to the CHA2DS2VASc scale), receiving DOAC (rivaroxaban, apixaban or dabigatran) for the prevention of thromboembolic complications * The following indications for the use of rebamipide and/or pantoprazole: * Chronic gastritis with high acidity in combination with gastroesophageal reflux disease * Peptic ulcer if negative test for H. pylori * Сhronic erosive gastritis * Need for Exclusion Criteria: * Refusal to participate in the study * Participation in any other clinical trial or taking study drugs within 3 months before enrollment; * Contraindications to study procedures * Participation in the study is unsafe according to the investigator opinion. * Admission of prohibited medication * Pregnancy and lactation, as well as the inability to use reliable contraception in women of childbearing age * Peptic ulcer in the acute stage * Acute erosion on screening visit

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Conditions

The condition(s) this trial relates to.

atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation (AF)

Contacts and locations

Locations

  • Russian Research and Clinical Center for Gerontology

    Moscow, 129226, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.