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Second ablation may zap hidden heart triggers

NCT ID NCT04111731

Knowledge-focused Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 44 people with persistent atrial fibrillation who had a second heart procedure 2 months after their first ablation. Doctors checked for reconnections in the pulmonary veins and treated them again to see if this improves outcomes. The goal was to better understand how to make the initial treatment more lasting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Mar 2020

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 to 80 years 2. Evidence of persistent Atrial Fibrillation Exclusion Criteria: 1. Any previous catheter (or surgical) ablation for atrial fibrillation or cryoballoon pulmonary vein isolation 2. An indwelling atrial septal defect (ASD) occluder device or anatomical structure that pre-vents free access to the left atrium 3. Left atrial diameter on transthoracic echo (Parasternal long axis, M-mode) \> 5.5cm 4. Recent stroke/Transient Ischaemic Attack within 3 months 5. Inability, unwillingness or absolute contraindication to taking oral anticoagulant medication 6. Severe kidney impairment (estimated Glomerular Filtration Rate \< 30ml/min) 7. Morbid obesity (Body Mass Index ≥40) 8. Extreme frailty 9. Severe valvular heart disease of any kind as assessed by the investigator, with or without prosthetic valve in place 10. Pregnancy

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation Persistent atrial fibrillation

Contacts and locations

Locations

  • Liverpool Heart and Chest Hospital NHS Foundation Trust

    Liverpool, L14 3PE, United Kingdom

  • Manchester University NHS Foundation Trust

    Manchester, M13 9WL, United Kingdom

  • The Newcastle Upon Tyne Hospital NHS Foundation Trust, Freeman Hospital

    Newcastle upon Tyne, NE7 7DN, United Kingdom

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