New study tests better way to freeze away heart rhythm problem
NCT ID NCT05296824
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 320 adults with paroxysmal atrial fibrillation (a type of irregular heartbeat) to compare two cryoballoon ablation techniques: freezing only the pulmonary veins versus freezing both the veins and the back wall of the heart's left upper chamber. The goal was to see which method better prevents the heart rhythm problem from coming back over more than three years. Researchers reviewed past medical records from a single hospital to find the answer.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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320 people
The number who actually took part.
- Started
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Jan 2014
- Finished
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Dec 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with symptomatic paroxysmal atrial fibrillation
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 years or older * Cryoballoon PVI+PWI * Cryoballoon PVI alone * Symptomatic paroxysmal atrial fibrillation Exclusion Criteria: * None
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Mercy General Hospital and Dignity Health Heart and Vascular Institute
Sacramento, California, 95819, United States
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UC Health Medical Center
Loveland, Colorado, 80538, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Pulsed electric fields take aim at irregular heartbeats
- Could a bigger balloon tame the Heart's electrical chaos?
- Can a new heart ablation technique work without x-rays?
- Could a gentle sedation cocktail replace general anesthesia for heart ablation?
- Can a new freezing balloon tame a fluttering heart as well as the old one?
- Heart signals may reveal if a common AFib procedure will last