University Of British Columbia

This study looks at whether two doses of the HPV vaccine can protect women living with HIV as well as the standard three doses. Researchers will enroll 275 women across Canada and compare immune responses over two years. If successful, fewer doses could make HPV vaccination cheap…

This study looks at whether a 6-month program combining exercise, mindfulness, and nutrition can improve thinking, sleep, inflammation, and other health markers in people with Parkinson's disease. 60 adults aged 40 to 85 will take part. Everyone gets the program, but some start r…

This study tests a new gel form of the chemotherapy drug gemcitabine (ST-02) for people with low-grade cancer in the upper urinary tract. The gel is placed directly into the kidney through a small tube, once a week for six weeks, to destroy tumors. Researchers want to see if it c…

This study tests whether a community-based program can reduce malnutrition in children aged 7-23 months in Punjab, Pakistan. Mothers attend daily group sessions to learn practical feeding and hygiene skills using local foods, then practice at home with staff support. The goal is …

This study tests a non-invasive spinal cord stimulation device in 30 people with chronic spinal cord injury. The goal is to see if it can help control blood pressure, bladder, bowel, and sexual function. Participants will receive stimulation over several weeks and be monitored fo…

This study looks at whether careful monitoring is as effective as bracing for babies under 3 months with mild hip dysplasia. Bracing can disrupt bonding and daily life, so avoiding unnecessary treatment could help families. The trial will involve 514 babies across 7 countries to …

This study looks at whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to the standard anti-TNF medicine (infliximab) helps children with Crohn's disease feel better and have fewer flare-ups. About 140 children starting infliximab will be randomly assi…

This study tests whether a noninvasive spinal cord stimulation device can improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans from Canada and Ukraine will receive either real or sham stimulation alongside standard rehab. The goal is to…

This study will compare two types of iron (ferrous fumarate and ferrous bisglycinate) in daily prenatal vitamins for 172 pregnant women in Vancouver. The goal is to see which form better improves iron stores in the mother and baby, while also checking for side effects like consti…

This study tests a program called AHEAD that helps young people aged 16-19 with type 1 diabetes improve their blood sugar control as they move from pediatric to adult diabetes care. About 306 participants will either get usual care or the AHEAD program, which offers tailored supp…

This study looks at whether giving iron supplements to children with low iron before hip surgery can lower their need for blood transfusions and improve recovery. The trial includes 180 children aged 0-18 who are scheduled for a specific type of hip surgery, many of whom have cer…

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study compares two types of surgical slings—one made from synthetic mesh and one from the patient's own tissue—to treat stress urinary incontinence in women aged 60 and older. Researchers will track pain and cure rates for up to five years after surgery. The goal is to find …

This study will test whether people with Parkinson's disease can stick to a Mediterranean-style diet for 18 months and whether it helps their gut health and symptoms. About 40 participants without dementia will be randomly assigned to either the special diet or a standard diet. R…

This study looks at whether people with Lynch syndrome can collect their own vaginal samples at home to check for early signs of uterine cancer. About 30 participants will use a self-collection kit and answer health surveys. The goal is to see if this method is easy, acceptable, …

This study aims to find a non-invasive method to predict endometrial (uterine) cancer risk in people with abnormal uterine bleeding. Researchers will collect health questionnaires and vaginal samples from 1,000 participants who are already scheduled for a biopsy. A smaller group …

This study tests whether short, one-minute bursts of exercise (called 'exercise snacks') can improve heart and lung fitness in adults with obesity. Researchers will enroll 80 inactive adults aged 35-64 with a BMI of 30-45. Participants will use a smartphone app to track their exe…

This study tests whether virtual reality (VR) can help people with vaginismus, a condition where pelvic floor muscles tighten involuntarily, making vaginal penetration painful or impossible. Twenty participants will use VR to gradually face feared situations, aiming to reduce fea…

This study tests whether personalized health coaching can help older adults with limited mobility become more physically active. Researchers will compare a coaching program to standard health education in 290 participants. The goal is to see if coaching improves walking speed, ba…

This study tests whether a daily probiotic can reduce depression symptoms in people with Parkinson's disease. 60 participants will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure mood changes using standard depression questionnaires. The g…

This study looks at whether a 3-month pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Researchers will track how many people join, stick with the program, and report any problems. They will also explore if the tra…

This study tests a mobile app called MI-Coach: ED designed to help adults with eating disorders feel more motivated and ready for treatment while they are on a waitlist. About 74 women in British Columbia will either use the app for four weeks or stay on the waitlist as usual. Re…

This study tests whether a short course of prednisone, an anti-inflammatory medication, can help treat complex regional pain syndrome (CRPS) early after a wrist fracture. About 40 adults who had wrist surgery and are at risk for CRPS will receive either prednisone or a placebo fo…

This study looks at whether a twice-weekly exercise program can improve sleep quality in people who had a stroke at least a year ago and currently have poor sleep. About 62 adults aged 55 and older will take part in a 6-month program. The goal is to see if exercise helps them fal…

This study is testing an online program called eSense-Cancer to help people who have had gynecologic cancer with sexual health issues. About 60 participants will use the program and report changes in sexual distress and satisfaction. The goal is to make support more accessible, e…

This study explores whether listening to personalized music can help reduce apathy (lack of motivation and emotion) in people with Parkinson's disease. Researchers will use brain scans to see how music affects areas linked to reward and movement. 50 adults with Parkinson's will l…

This study looks at whether adding pelvic floor muscle training to standard rehab helps people with spinal cord injury improve bladder, bowel, and sexual function. About 50 adults currently in rehab will do 6 weeks of pelvic floor physical therapy. Researchers want to see if the …

This study tests an online program called STEP for couples who are distressed by having different levels of sexual desire. About 216 couples will be randomly assigned to a therapist-guided version, a self-guided version, or a waitlist. The goal is to see if the program reduces di…

This study tests whether a 5-week breathing exercise program using a special device can reduce breathlessness and improve exercise performance in healthy athletes. Researchers will measure changes in breathing discomfort and oxygen use during cycling. The goal is to better unders…

This study looks at how a 6-month program of exercise, mindfulness, and nutrition affects thinking, inflammation, sleep, and physical health in 60 healthy adults aged 50 to 75. Participants either start the program right away or wait 6 months before starting. The goal is to under…

This study tests whether a set of tools can help doctors and nurses order fewer unnecessary lab tests for hospitalized patients. Over 700,000 patients and their healthcare providers across 16 hospitals in British Columbia will take part. The goal is to improve patient care and re…

This study follows 4,000 children who receive orthopedic implants (like rods, screws, or plates) for broken bones, limb deformities, or hip problems. Researchers will track how well the implants work, how long they last, and any side effects. The goal is to make sure these device…

This study looks at why people with interstitial lung disease (ILD) often feel short of breath and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 adults with ILD, and test whether extra ox…

This study aims to find out if vaping harms the lungs in ways standard tests miss. Researchers will use advanced breathing tests, exercise tests, and lung scans in 500 Canadian teens and adults who vape, smoke, or do neither. The goal is to give vapers clear information about the…

This study tests a new physical activity counseling method for older adults with early frailty. Researchers will compare it to the current approach used by physiotherapists. The goal is to see if the new method helps patients be more active and manage chronic conditions better. A…

This study tests whether regular text messages with health tips can help pregnant people gain the right amount of weight, attend prenatal visits, and learn more about healthy pregnancy. About 3,000 pregnant people in Canada will either get behavior-focused texts or general pregna…

This study follows 3,500 adults who have large colon polyps (20 mm or bigger) to see how well doctors remove them using a scope. No new treatments are tested—doctors use standard care. The goal is to learn what leads to successful removal and fewer complications.

This study looks at whether Cambodia's health system is ready to give pregnant women a multiple micronutrient supplement (MMS) instead of just iron and folic acid. Researchers will interview healthcare providers, survey 630 pregnant women, and monitor vitamin supplies. The goal i…

This study looks at how the gut bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may affect their baby's gut health. Researchers will collect samples from 80 mothers and their infants over a year to measure gut inflammation and identify patterns. The goal…

This study tests a virtual reality (VR) tool called bWell to see if it can help assess and improve thinking skills in people with major depression. About 40 adults aged 19-55 with mild depression and self-reported memory or focus issues will try the VR assessments and either cogn…

This study tests whether using special devices to track vital signs more closely in the hospital and at home can help people recover better after major abdominal or vascular surgery. About 110 adults will be randomly assigned to either enhanced monitoring or standard care. The ma…

This study looks at how histamines, the same molecules that cause allergy symptoms, affect blood flow in the lungs after exercise. Researchers will measure blood pressure in the lungs of 20 healthy adults aged 19-39 after they exercise, comparing results when histamine action is …

This study is a registry that collects health information from 714 adults with severe asthma across Canada over five years. Researchers will track things like lung function, asthma attacks, and treatments to understand how well current therapies work. The goal is to use this real…

This study looks at whether women need different amounts of the essential amino acid phenylalanine during different phases of their menstrual cycle. Current recommendations are based on studies in men and may not fit women. Researchers will use special diets and a simple breath t…

This study looks at whether counting daily steps can be a simple, low-cost way to measure frailty in older adults (65+) who are in the hospital. Researchers will track 120 participants' upright time and step counts, and compare them with standard frailty tests. The goal is to see…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers want to see if a specific group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy,…

This study is creating a Canada-wide registry of people who come to emergency departments after an opioid overdose. Researchers will track what treatments patients receive and look for patterns to help predict who is at highest risk of dying within 60 days. The goal is to find th…

This study watches brain activity in 30 organ donors after death to make sure no brain function returns during a procedure that restores blood flow to organs for transplant. Using special monitors, researchers check that the donor remains brain-dead throughout. The goal is to con…

This study looks at whether 6 months of resistance exercise (like lifting weights) can improve thinking and memory in perimenopausal women aged 40 to 55 who are not active and have memory complaints. Researchers will also check effects on muscle health, sleep, mood, and quality o…

This study tests whether a machine learning program can detect hidden lumps (lipohypertrophy) under the skin where people with diabetes inject insulin. These lumps can change how insulin is absorbed and raise blood sugar. Researchers will use portable ultrasound images to train t…

This study looks at whether eating more fatty fish, fruits, and vegetables can help protect the lungs from the harmful effects of woodsmoke. Researchers will ask 48 healthy adults to follow a special diet and then measure how their lungs respond to woodsmoke exposure. The goal is…

This study looks at whether giving protein all at once (bolus) or slowly over time (continuous) helps critically ill children ages 1 to 11 maintain weight and muscle better. Researchers will measure arm size and use ultrasound to track changes over two weeks. The goal is to find …

This small study is testing whether combining electrical stimulation of a nerve in the leg with standing therapy can improve pelvic floor muscle function in adults with chronic spinal cord injury. Twelve participants will undergo 12 weeks of combined therapy and complete question…

This study looks at how much leucine, a key protein building block, healthy pregnant women need during early and late pregnancy. Researchers will give participants special meals and collect breath, urine, and one blood sample to track how the body uses leucine. The goal is to imp…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is practical for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and interviews about their activity, pain, and well-b…

This study is looking at whether the unique mix of bacteria and fungi in the gut can help predict how well a person with Crohn's disease will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia during routine colonos…

This study is testing a genetic test panel in 150 children who take common medicines like painkillers, antibiotics, or mental health drugs. The goal is to see if the test can help predict and prevent serious side effects. Researchers will also learn how doctors, pharmacists, and …

This study looks at whether having peer support workers—people who have personally used drugs—in the emergency department can make patients more comfortable and reduce the number who leave before their care is complete. About 3,181 adults who visit the ER and use substances can t…