University Of British Columbia

This study tests a new approach to help people with chronic spinal cord injury improve arm and hand function. It combines two non-invasive stimulation techniques: one on the brain and one on the spinal cord. 24 participants will receive either both stimulations, spinal stimulatio…

This study compares two procedures—catheter ablation and pacemaker therapy—for people with both atrial fibrillation (irregular heartbeat) and heart failure. About 1,056 adults will be randomly assigned to one of the two treatments. The goal is to see which approach better reduces…

This study tests adding a new drug, nerandomilast, to the standard treatment mycophenolate for people with pulmonary fibrosis (lung scarring). About 120 adults with various types of lung fibrosis will take the combo for 4 months. The main goal is to see if most patients can stay …

This study tests whether a single low dose of the medicine indomethacin, given within 12 hours of birth, can prevent severe brain bleeding and improve survival in extremely premature babies (born before 26 weeks). About 500 infants across Canada, the US, and Australia will be ran…

This study tests an online educational program called Brain Health PRO that teaches lifestyle changes to lower dementia risk. About 700 adults at risk for dementia will either start the program right away or wait 6 months. The goal is to see if the program helps people adopt heal…

This early study tests a device worn around the neck that uses gentle suction to keep the airway open during sleep. It involves 10 healthy volunteers who will wear the device during one night of sleep testing. The goal is to see if the device is safe and can reduce breathing paus…

This study tests a non-invasive brain stimulation technique called iTBS to see if it can ease depression symptoms in young women aged 16 to 24. Only 8 participants will be enrolled, and the main measure is change in depression scores. It's an early-stage trial focused on symptom …

This study looks at whether new ways of programming deep brain stimulation (DBS) can help adults with essential tremor whose symptoms no longer improve with standard DBS. Five participants will try six different stimulation settings in the clinic and use one at home for three mon…

This study looks at how breathing in wildfire smoke can lead to long-term lung problems like asthma, COPD, and lung cancer. Researchers will safely expose 24 healthy adults to different levels of smoke in a controlled setting. The goal is to learn who is most at risk and what bio…

This study looks at whether doing a lat pulldown (arms overhead) or a lat row (arms at a right angle) leads to more muscle growth in the back and arms. Twenty healthy adults who already lift weights will train each arm with a different exercise for 12 weeks. Researchers will meas…

This study looks at whether giving dentists personalized reports and educational materials can reduce how often they prescribe opioids for dental pain. About 3,500 dentists in British Columbia will take part. Some will get the materials early, others later, and researchers will c…

This study looks at how the hormones estrogen and testosterone affect blood flow and energy use in the brain. Researchers will temporarily block these hormones in 50 healthy young men and women, then give them back to measure changes. The goal is to understand sex differences in …

This study aims to find out how much leucine—an essential amino acid found in meat, dairy, eggs, beans, and nuts—healthy children aged 6 to 10 need each day. Current guidelines are based on adult needs, but this research uses special diets, safe stable isotopes, and simple breath…

This study looks at people with p53-mutated oral dysplasia (abnormal cells) and early-stage oral cancer to find the best treatment at each stage. Researchers will compare surgery versus observation for low-grade dysplasia, different surgical margins for high-grade dysplasia, and …

This study looks at two kinds of stitches used to repair small belly button hernias (less than 2 cm). One type dissolves over time, while the other stays in the body permanently. Researchers want to see if one leads to fewer hernias coming back or causes fewer problems after surg…

This study looks at whether asking new mothers simple questions within 24-48 hours after an unplanned C-section can predict if they will develop post-traumatic stress disorder (PTSD) related to childbirth. Researchers will follow 420 participants for 3 months, comparing early scr…

This study tests whether sending family doctors and nurse practitioners a personalized report of their antibiotic prescribing habits can reduce unnecessary prescriptions. About 7,600 clinicians in British Columbia will be randomly assigned to receive the report either early or af…

This study tests whether a new ultrasound method can measure liver stiffness and fat as accurately as MRI or the current standard test (FibroScan). It includes 145 healthy volunteers and patients with fatty liver disease. The goal is to offer a simpler, cheaper alternative to MRI…

This study looks at the best time to moisturize for teens aged 12-18 with eczema. Participants will apply moisturizer while in the shower or bath for one month, then after towel drying for another month. Researchers will measure skin hydration, itch, and eczema severity to see wh…

This study looks at how starting a running program affects knee health in people with knee osteoarthritis (OA). Researchers will use MRI scans to measure changes in knee cartilage over time. The goal is to understand if recreational running is safe for those with knee OA. Partici…

This study follows 310 people having planned cesarean births with spinal anesthesia. Researchers will ask participants about sensations they feel during surgery and whether any are too uncomfortable. The goal is to better understand and manage pain and stress during C-sections.

This study tests a device called Calmer that mimics a parent's touch, heartbeat, and breathing for preterm babies in the NICU. Researchers will use brain scans to see if using Calmer for at least 3 hours a day over 2-3 weeks affects brain growth compared to standard care. The stu…