University Of British Columbia

This study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…

This study looks at the best way to treat people with p53-mutant oral dysplasia (abnormal cells in the mouth) and early-stage oral cancer. About 636 adults will be placed into three groups based on their diagnosis and receive either monitoring, surgery, or surgery plus neck disse…

This study tests whether adding nerandomilast to the standard drug mycophenolate is safe and tolerable for people with pulmonary fibrosis (lung scarring). About 120 adults with various types of lung fibrosis will take the combination for 4 months. The main goal is to see how many…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This study tests whether removing the fallopian tubes at the same time as gallbladder surgery is safe and practical. Ovarian cancer often starts in the fallopian tubes, so removing them may prevent it. The trial will enroll 240 women aged 35 and older to see if the extra procedur…

This study tests whether a single low dose of the drug indomethacin, given within 12 hours of birth, can prevent severe brain bleeding and improve survival in extremely preterm infants (born before 26 weeks or weighing under 750 grams). About 500 babies across Canada, the US, and…

This study tests whether a short liquid diet followed by a low-sulfur eating plan is safe and helpful for people with mild to moderate ulcerative colitis. Researchers will check if this approach improves gut health, lowers inflammation, and eases symptoms. They will also use brea…

This study tests whether wearing a virtual reality headset during dental treatment can reduce pain and anxiety in children aged 6 to 12. Eighty children will be randomly assigned to either use VR or receive standard care. Researchers will measure pain, stress, and how willing kid…

This pilot study tests whether combining non-invasive brain stimulation (over the cerebellum) with spinal cord stimulation can improve arm and hand function in people with chronic cervical spinal cord injury. Twenty-four participants will receive either both stimulations, spinal …

This study looks at whether new ways of programming deep brain stimulation (DBS) can improve tremor control in adults with essential tremor who stopped responding to standard DBS. Five participants will try six different stimulation settings and use one at home for three months. …

This early study tests a neck device that uses gentle suction to keep the airway open during sleep, which might help people with obstructive sleep apnea. Ten healthy volunteers will wear the device during one night of sleep and compare their breathing to a night without it. The g…

This study looks at whether applying moisturizer while still in the shower or bath is better than applying it after towel drying for teens with eczema. Thirty participants aged 12-18 will try each method for one month and report which they prefer. Researchers will also measure sk…

This study tests a non-invasive brain stimulation technique called iTBS to help ease depression in young women aged 16 to 24. Eight female participants will receive the treatment to see if it improves mood and brain function. The goal is to find a new way to reduce depression sym…

This study looks at whether a treadmill that moves each leg at a different speed can help people who had a stroke walk more evenly and faster. About 30 people who had a stroke within the last 9 months will take part. A physiotherapist will guide them through walking exercises on …

This study will ask 50 people aged 35 and older with abnormal uterine bleeding to collect daily urine samples and track their bleeding at home for several months. Researchers will use a home monitor to measure hormone levels and see if certain patterns are linked to uterine cance…

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study follows 310 women having planned C-sections with spinal anesthesia. Researchers will ask them about any sensations they feel during surgery, how intense they are, and whether they find them unacceptable. Participants also complete questionnaires about mood and well-bei…

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether …

This study aims to find out how much leucine—a key amino acid found in meat, dairy, eggs, beans, and nuts—healthy children aged 6 to 10 need each day. Researchers will give special diets and safe, non-radioactive tracers, then collect breath and urine samples to measure how the b…

This study evaluates a program that sends family doctors and nurse practitioners a confidential report comparing their antibiotic prescribing to peers, along with an educational summary. Over 7,600 practitioners in British Columbia will be randomly assigned to receive the report …

This study looks at how the hormones estrogen and testosterone control blood flow to the brain. Researchers will temporarily block these hormones in 50 healthy young men and women, then measure brain blood flow and energy use. The goal is to understand sex differences in brain he…

This study will test whether a special ultrasound technique can measure liver stiffness and fat as accurately as MRI in people with fatty liver disease. Researchers will compare results from both imaging methods in 145 healthy volunteers and patients. The goal is to find a simple…

This study compares two common gym exercises—lat pulldown and lat row—to see if the angle of your shoulder affects muscle growth. Twenty healthy adults aged 19-30 will train each arm with a different exercise for 12 weeks. Researchers will measure muscle size and strength changes…

This study tests whether giving dentists personalized reports comparing their opioid prescribing to others, along with educational materials, can reduce opioid use for dental pain. About 3,500 dentists in British Columbia will be randomly assigned to receive these materials early…

This study tests a device called Calmer that mimics a parent's touch, heartbeat, and breathing for very preterm infants in the NICU. Researchers will use brain scans to see if using Calmer for at least 3 hours daily over 2-3 weeks improves brain development compared to standard c…

This study looks at two types of stitches used to repair small belly button hernias (defects 2 cm or smaller). About 900 adults having elective surgery will be randomly assigned to receive either absorbable or permanent stitches. Researchers will track hernia recurrence and other…