New gel could zap kidney cancer without surgery

NCT ID NCT06124976

Recruiting now Disease control Sponsor: Peter Black Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study tests a gel form of the chemotherapy drug gemcitabine, called ST-02, for people with low-grade cancer in the upper urinary tract. The gel is placed directly into the kidney through a small tube. The goal is to see if it can destroy tumors within three months and remain safe. About 70 adults with small, low-grade tumors will receive six weekly treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ST-02 (mucoadhesive gemcitabine suspension)
What this could lead to: If it works, this could offer a less invasive way to treat low-grade upper urinary tract cancer, potentially avoiding surgery.
What could go wrong: This is an early-phase trial with only 70 participants. The treatment may not fully eliminate tumors, and side effects from the chemotherapy gel are possible.

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Conditions

The condition(s) this trial relates to.

renal pelvis/ureter urothelial carcinoma urinary tract non-invasive transitional cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER UROTHELIAL CARCINOMA OF THE RENAL PELVIS AND URETER

Contacts and locations

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Locations

Centre Hospitalier de l'Université de Montréal (CHUM)
NOT_YET_RECRUITING

Montreal, Quebec, Canada
Centre de recherche du CHUS
NOT_YET_RECRUITING

Sherbrooke, Quebec, Canada
Centre of Applied Urology Research, Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, Canada
London Health Sciences Centre - Victoria Hospital
RECRUITING

London, Ontario, Canada
McGill University Health Center
RECRUITING

Montreal, Quebec, Canada
Men's Health Clinic
RECRUITING

Winnipeg, Manitoba, Canada

Contact Email: •••••@•••••
UHN - Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, Canada
Vancouver Prostate Centre
RECRUITING

Vancouver, British Columbia, Canada

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