University Hospital, Brest

This phase 3 trial tests whether adjusting the flow rate of high-flow oxygen therapy based on lung volume measurements from a depth camera can reduce the need for intubation in intensive care patients with hypoxemic respiratory failure. About 406 participants will be randomly ass…

This study tests whether injecting a medical glue into an artery in the brain can prevent chronic subdural hematomas from coming back. These are blood collections on the brain's surface that often recur after standard treatment. The trial will enroll 550 adults and compare glue e…

This study tests whether personalized support from a sport and health professional after cardiac rehabilitation helps heart failure patients maintain their physical activity levels. 90 participants will be followed for 12 months, with activity measured by a step counter. The goal…

This study tests whether the Luna EMG rehabilitation robot can help people who had a stroke more than a year ago improve arm movement. Five participants will use the robot for 30 minutes per session as part of their rehab. The goal is to see if the robot can make arm movements sm…

This Phase 3 trial tests whether adding baricitinib (a JAK inhibitor pill) to standard steroid treatment can help people with polymyalgia rheumatica achieve disease control without needing long-term steroids. About 140 adults aged 50+ with active PMR will receive baricitinib (2 m…

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifesty…

This phase 3 trial is testing whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban are better than low-dose aspirin at preventing blood clots in people with JAK2V617F-positive myeloproliferative neoplasms (blood cancers). The study plans to enroll 1308 high-ris…

This study tests whether a nurse-led prevention program can reduce the burden of side effects in people starting long-term corticosteroid therapy. About 191 adults will either receive the nurse program or standard care. The goal is to see if the program lowers complications like …

This study tests whether giving botulinum toxin (Botox) injections early can prevent shoulder bone deformities in babies with obstetrical brachial plexus palsy, a nerve injury at birth. About 62 babies aged 10-11 months will receive either the injection or a sham procedure. The g…

This study tests whether a shared decision-making process, which uses personalized risk scores, can help patients with unprovoked blood clots choose the best duration of blood-thinning medication. The goal is to reduce the chance of another clot or serious bleeding while improvin…

This study tests a portable ultrasound system to measure the position of the shoulder blade (scapula) in patients with shoulder arthritis while they stand. The goal is to see if this non-radiation method can give results similar to CT scans taken when lying down. Thirty adults sc…

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study is testing a new type of PET/CT scan that uses a special tracer to see if it can better detect and monitor chronic inflammatory and fibrotic diseases like rheumatoid arthritis, liver fibrosis, and lupus. About 390 adults with these conditions will get the scan to measu…

This study is testing a new type of PET scan to see if it can tell the difference between cancer that is still there and swelling caused by radiation treatment in people with head and neck cancer. About 180 adults who finished radiation therapy will get this special scan 3 months…

This study looks at whether giving blood thinners (LMWH) for 6 weeks after childbirth can prevent dangerous blood clots in women who have a moderate risk. About 2,400 women will be randomly assigned to receive either the blood thinner or standard care without it. The goal is to s…

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This study tests whether using a special dye (indocyanine green) during total thyroidectomy helps surgeons see and protect the parathyroid glands, reducing the risk of permanent hypoparathyroidism. About 242 adults scheduled for total thyroid removal will be randomly assigned to …

This study tests whether personalized follow-up with a sport-health professional helps people with chronic respiratory diseases maintain the benefits of pulmonary rehabilitation. 352 participants will either receive tailored support or usual care. The main goal is to see if those…

This study tests whether a respiratory rehabilitation program—including exercise training, breathing exercises, and education—can improve quality of life for people with advanced non-small cell lung cancer who are on maintenance chemotherapy and immunotherapy. Researchers will co…

This study tests whether a 3-month pulmonary rehabilitation program (20 sessions of exercise and education) can improve quality of life and reduce breathlessness in people who have had a pulmonary embolism. Researchers will enroll 112 adults who still have symptoms at least 3 mon…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or injury. Half the teens get the real patch, the other half get a placebo dressing. Pain leve…

This study tests whether wearing Boarding Ring glasses can help people with vestibular neuritis (a sudden, severe vertigo attack) recover their balance more quickly. Researchers will measure changes in balance and eye movements over one week in 51 adult patients. The glasses are …

This study tests a mobile team of pain specialists who visit children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities. The team works with families and caregivers to assess and manage pain in the patient's usual …

This study tests whether a nose spray made from treated seawater can shorten the time babies (1 month to 1 year) have symptoms of bronchiolitis, compared to a standard saltwater spray. About 458 infants with their first, mild-to-moderate bout of bronchiolitis will take part. Pare…

This study is gathering blood, stool, and skin samples from 100 adults with systemic sclerosis to learn more about the disease. Researchers will also track health information like skin thickness, lung function, and quality of life over time. The goal is to build a biobank for fut…

This observational study is looking at whether certain markers in the blood can predict immune-related side effects in cancer patients receiving immunotherapy. Researchers will collect blood samples and health data from 200 participants during routine visits. The goal is to bette…

This study aims to create a 'patient library' by collecting blood, stool, and hair samples from 250 people aged 15 to 30 who have had a first psychotic episode or are at high risk. Researchers will track their mental health over 10 years using the CAARMS test. The goal is to bett…

This study is looking at how well current classification criteria can diagnose primary Sjögren's syndrome, a rare autoimmune disease. Researchers will compare the criteria against diagnoses made by expert doctors. The goal is to improve diagnostic accuracy for this condition.

This study is measuring a protein called STIM1 on the surface of immune cells in 670 people with various autoimmune diseases. The goal is to find which diseases have high levels of this protein, which could help researchers develop new antibody-based treatments. Participants prov…

This study tests a home-based program called IBAIP for very preterm babies (born before 33 weeks). The program coaches parents to support their baby's self-regulation and development from hospital discharge to 6 months corrected age. Researchers will measure the babies' cognitive…

This study gathers blood and bone marrow samples from 150 adults with myelodysplastic syndrome (MDS), a blood disorder that can turn into acute leukemia. Researchers want to find biological markers that help predict which patients are likely to progress to leukemia. The goal is t…

This study looks at whether training paramedics with simulations can make brain tumor patients more satisfied with their care. About 250 adults with a newly discovered brain tumor will fill out a questionnaire after their hospital stay. The goal is to see if this training helps p…

This study is building a library of information and samples from 60 adults with suspected autoimmune myopathy, a rare muscle disease. Researchers will collect blood, urine, stool, and muscle tissue, along with medical data, to better understand the condition. The goal is to impro…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study is collecting blood, urine, and fecal samples from 100 people with ANCA-associated vasculitis, a rare autoimmune disease. Researchers will follow participants for up to 5 years, tracking relapses and complications. The goal is to identify factors that predict disease f…

This study aims to understand why some women have a sensitive scalp—a condition that causes tingling, burning, or pain from everyday triggers like hair styling. Researchers will compare skin biopsies and gene activity in 40 women (20 with sensitive scalp, 20 without) to find biol…

This study aims to collect blood, skin swabs, skin biopsies, and questionnaire data from 175 adults with chronic itch that has no known skin cause (pruritus sine materia). Researchers hope to better describe the condition and uncover clues about what drives it. Participants will …

This study is collecting blood and urine samples from 150 cancer patients who have had blood clots. The goal is to learn more about why clots happen in cancer and how to prevent them. Participants will be followed over time to track clot recurrence and bleeding risks.

This study looks at 32 people who still have shortness of breath or reduced quality of life after a pulmonary embolism (a blood clot in the lungs). They will receive a special PET/CT scan before and after a pulmonary rehabilitation program to see how the treatment improves lung f…

This study is looking at whether women who have had a blood clot while using hormones (like birth control pills or during pregnancy) have family members who are also more likely to have had a clot. Researchers will compare the family history of these women with that of women who …

This study looks at 665 people who had a pulmonary embolism (a blood clot in the lung) and are at intermediate risk of another clot. Researchers will use a special 3D lung scan (V/Q SPECT/CT) to measure leftover blockages in lung blood vessels. The goal is to see if this scan can…

This study follows 3,400 people who have had a blood clot (venous thromboembolism) to see how often clots return and what raises the risk. It focuses on two groups: patients under 50, and cancer patients of any age. Researchers will track recurrences over 1 to 5 years and also mo…

This study looks at how emotional intelligence—the ability to understand and manage emotions—relates to chronic orofacial pain (pain in the face or mouth lasting over three months). Researchers will compare 88 adults with and without this pain using questionnaires about emotions,…

This study tracks 217 people after their first psychotic episode to see if language patterns and blood markers can predict whether they will develop bipolar disorder or schizophrenia. Participants give a recorded interview and blood sample at the start, then are followed for two …

This study looks at whether physical therapists can correctly identify movement control problems in people with chronic low back pain. Fifty participants will perform six simple movement tests while being filmed. Therapists will watch the videos and decide if the movement is norm…

This study looks at how preterm and full-term babies adapt to noises and lights—a skill called habituation. Researchers will compare 70 infants near their due date to see if differences in this ability can help spot those at risk for developmental delays. The goal is to find earl…

This study looks at whether inflammation after a minimally invasive heart valve replacement (TAVI) can cause dangerous heart rhythm problems. Researchers will use a special PET scan to measure inflammation in the heart's electrical pathways. The goal is to better predict which pa…

This study is testing a new radioactive tracer designed to attach to active blood clots and make them visible on a PET scan. Researchers will take blood samples from 10 healthy volunteers, create clots in the lab, and see how well the tracer binds to them. The goal is to develop …

This study is testing whether subtle changes in how people speak can predict who will develop schizophrenia. Researchers will record and analyze free speech from 215 young people aged 15-30 who are at ultra-high risk for psychosis. By using computer programs to detect semantic an…

This study looks at a condition called alloknesia, where light touch—like from clothing or a breeze—triggers itching. Researchers want to find out how common this is in people with atopic dermatitis (eczema) and how it affects their daily lives. About 160 adults with eczema will …

This study tests whether patients can wear a virtual reality (VR) headset during awake brain surgery to help them stay calm and complete thinking and language tests. First, the VR headset was tested on people having orthopedic surgery under local anesthesia to make sure it is saf…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study aims to find genetic factors that may cause repeated miscarriages or unexplained fetal deaths. Researchers will collect biological samples from 200 couples who have experienced at least three early miscarriages or a fetal death in the second or third trimester. By comp…

This study looks at whether ultrasound scans of the temporal and axillary arteries can help predict relapses in people with giant cell arteritis, a disease that causes inflamed blood vessels. Researchers will follow 100 patients to see if certain ultrasound findings are linked to…

This observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…

This study uses a special two-way mirror device to see how teenagers and young adults at risk for psychosis recognize themselves versus others. Participants sit opposite a healthy volunteer and report who they see as lighting changes. The goal is to find differences in self-other…

This study aims to find early signs that predict quality of life more than four years after a minor ischemic stroke. Researchers will analyze data from 1,000 patients, including MRI scans, saliva samples, and questionnaires. The goal is to build a model that helps doctors underst…

This study reviews existing eye scans from 190 adults to see how consistently doctors can measure the muscles that move the eyes, the optic nerve, and the fat inside the eye socket. The goal is to improve how these structures are assessed for medical and surgical planning. No new…

This study is not testing a new drug or treatment. Instead, researchers are combining health information from 20,000 people across 14 European groups who have had blood clots (venous thromboembolism). By merging this data, they hope to better understand who is at risk for future …

This study is testing a secure app called Deneo Kid to see if it helps families and doctors better coordinate rehabilitation care for children and young people with neuromotor disabilities (like cerebral palsy or brain injury). About 20 children, their families, and their care te…

This study is testing a 10-week group parenting program called EQUIPE for parents with alcohol use disorder who have children aged 4 to 12. The goal is to see if the program reduces parental stress and improves parent-child relationships. Researchers will enroll 90 parents and me…

This study examines how B cells, a type of immune cell, behave in the blood and gums of people with periodontitis (gum disease). Researchers want to see if certain B cell patterns are linked to more aggressive disease and how they change after surgery. The goal is to improve diag…

This study tests a French version of a questionnaire that measures the burden on caregivers of people with COPD. Researchers will ask 224 caregivers to fill out the questionnaire along with other surveys to see if it works well. The goal is to give doctors a reliable way to spot …