University Hospital, Brest

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This French phase 3 trial compares pembrolizumab alone versus pembrolizumab plus chemotherapy as a first treatment for advanced non-small-cell lung cancer with high PDL1 levels (50% or more). About 349 participants are enrolled. The goal is to see if the combination reduces early…

This study aimed to see if ultrasound could accurately predict whether a swollen lymph node is benign or malignant. Researchers planned to compare ultrasound results with standard tests like needle sampling or biopsy. The goal was to speed up diagnosis and avoid unnecessary invas…

This study looks at whether a detailed full-body scan called FDG PET/CT can find hidden cancers in people aged 50 and older who have had an unexplained blood clot. About 1,276 participants will get either the scan or standard cancer checks. The goal is to see if the scan catches …

This study compares two ways to sedate ICU patients who need a breathing machine: inhaled sedation (using isoflurane gas) versus standard intravenous (IV) sedation. The goal is to see if the inhaled approach reduces the chance of delirium—a state of confusion that often occurs in…

This study planned to see if injecting a patient's own fat into the fingertip could reduce pain and discomfort after a fingertip amputation. It was designed for adults with persistent nerve pain lasting 6 to 24 months after injury. However, the study was withdrawn before enrollin…

This study follows 25 adults with inactive lupus to see if blood samples can predict when a flare will happen. Researchers will analyze genes and other molecules to find patterns linked to flare risk. The goal is to develop tools that help doctors personalize treatment and preven…

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study follows 70 infants with cystic fibrosis to see if a specific germ (Porphyromonas catoniae) found in their body at 12 months old can predict whether they will get a serious lung infection with Pseudomonas aeruginosa by age 3. Researchers collect sputum, stool, and blood…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study was designed to test whether a French version of the Brief Fatigue Inventory (BFI) questionnaire works well for measuring fatigue in patients. It planned to enroll people whose main symptom was fatigue. However, the study was withdrawn before any participants were recr…

This study reviews medical records of about 30 adults who had surgery for a broken collarbone that didn't heal properly (nonunion). The goal is to see how often the bone heals after surgery and how patients recover. No new treatments or visits are involved—only existing data is u…

This study looks at the stroma—the supportive tissue around tumors—in both benign and malignant growths. Researchers will examine 7,000 patient samples collected since 2000 at Brest University Hospital. The goal is to count non-tumor cells and measure matrix percentages in tumor …

This study reviews the medical records of 20 adults who had a limb amputated to relieve severe, long-lasting pain from complex regional pain syndrome (CRPS). Researchers want to measure how many days pass between the amputation and when patients first use a functional prosthetic …

This study aims to create a reliable French version of the Female Sexual Distress Scale-Revised, a questionnaire that measures distress related to sexual function. Researchers will translate the original English questionnaire into French, then test it with 60 adult women to ensur…