University Hospital, Brest

This phase II trial tests whether a low-dose, frequent schedule of the chemotherapy drug vinorelbine, taken orally, can boost the effects of the immunotherapy atezolizumab in people with stage IV non-small cell lung cancer. The study enrolls adults whose cancer has progressed aft…

This study looked at whether using a soft hip brace (abduction splint) for two months in one-month-old babies with mild hip dysplasia (stable hips but abnormal ultrasound) improves hip development. 90 infants were enrolled. The goal was to see if the brace makes hip ultrasound me…

This phase 3 trial tested whether abatacept, a drug that calms the immune system, can control polymyalgia rheumatica (a painful inflammatory condition) without the need for long-term steroids. Thirty-four adults with early disease received either abatacept or a placebo for 12 wee…

This study tested an early, intensive therapy program called HABIT-ILE in 36 preschool children (ages 1-4) with bilateral cerebral palsy. The therapy focuses on coordinated use of both hands and legs through structured activities. Researchers measured changes in gross motor funct…

This study tested whether using a non-invasive ventilation machine for at least 7 days before lung cancer surgery could reduce lung and heart complications. The trial included 300 patients with lung cancer who also had breathing problems, obesity, or heart failure. The goal was t…

This study looked at whether taking a fast-acting insulin (Insulin Aspart) before or after meals makes a difference in blood sugar control for people with type 1 diabetes who use an insulin pump. Twenty-two adults participated, and their blood sugar was tracked continuously for 1…

This study compared two surgical methods to repair damaged knee cartilage: a newer cell-based technique (autologous chondrocyte implantation) and a standard bone-graft method (mosaicoplasty). 58 adults aged 18-50 with isolated knee lesions took part. The goal was to see which app…

This study tested a personalized approach to fluid management in 535 adults with septic shock. Doctors used a 'mini-fluid challenge'—a small amount of albumin given quickly—to check if more fluids would help, aiming to avoid fluid overload. The goal was to see if this tailored me…

This study tested a new way to diagnose cystic fibrosis in unborn babies using a simple blood sample from the mother. Instead of using a needle to take fluid from around the baby, researchers used advanced DNA sequencing to read the baby's genes from tiny bits of fetal DNA floati…

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tested two new devices that automatically measure vision in children aged 6 to 16. The devices use special lenses that adjust themselves, avoiding the need for eye drops that dilate the pupils. Researchers compared the results from 43 children to the standard dilation …

This study looked at 45 patients whose HPV tests came back negative but had a late signal in the raw data. Researchers wanted to see if these late signals might actually indicate early cervical cell changes. By comparing different lab methods, they aim to improve how we interpret…

This study tested whether a French version of the HSCL25 questionnaire can help general practitioners diagnose depression more accurately. Over 1,100 adults visiting their primary care doctor took the questionnaire, and their scores were compared to a standard diagnostic intervie…

This study tested a new CT scan method that creates a map of blood flow in the lungs to diagnose pulmonary embolism (blood clots). Researchers compared it to the standard SPECT scan in 30 patients. The goal was to see if the new method is as accurate, while being faster and safer…

This study tested whether a special PET/CT scan (V/Q PET/CT) can accurately diagnose pulmonary embolism (a blood clot in the lungs) compared to the standard CT scan. About 100 adults with suspected first-time clots took part. The goal was to see how sensitive and specific the new…

This study tested whether adding a leg compression device to elastic stockings reduces blood clots in intensive care patients at high risk of bleeding. Over 400 patients were randomly assigned to receive either the device plus stockings or stockings alone. The main goal was to se…

This study tested whether methoxyflurane (Penthrox®), a painkiller inhaled through a handheld device, can quickly reduce moderate to severe dental pain in adults. 190 participants in a dental emergency department received either methoxyflurane or a placebo alongside standard care…

This study tested a smartphone app called 'Bouge' to see if it could help pregnant women walk more each day. 250 pregnant women used either the Bouge app or a placebo app starting at 15 weeks. The goal was to increase daily steps by 2,000. Researchers also looked at sleep, well-b…

This study tested whether giving two types of light therapy (intense pulsed light and low-level light therapy) before laser eye surgery can help prevent dry eyes afterward. 62 people who were already scheduled for laser vision correction took part. The goal was to see if these tr…

This study tested two oral medications, aprepitant and hydroxyzine, to see which better reduces severe itching triggered by water contact in people with myeloproliferative neoplasms (a type of blood cancer). 63 participants who had persistent itching rated 5 or higher on a 10-poi…

This study tested whether LED light therapy can help people with sensitive skin who do not have other skin conditions like rosacea or acne. Thirty adults with sensitive skin received the treatment. The goal was to see if symptoms like pain and itching improved.

This study looked at two simple, drug-free ways to ease pain in newborns during a needle stick: breastfeeding or a sugar solution. Researchers measured brain activity and stress levels in 114 healthy, full-term breastfed babies. The goal was to see which method works better for c…

This study tested two methods to strengthen leg muscles in 102 people with severe COPD: electrical stimulation (using pads on the skin) and stationary cycling. Both were part of a 3-4 week hospital rehab program. The goal was to see which better improves leg function and exercise…

This Phase 3 trial tested the drug oxybutynin in 62 adults with excessive sweating (hyperhidrosis). Participants took either oxybutynin or a placebo, starting at a low dose and increasing gradually. The study measured how well the drug reduced sweating and improved quality of lif…

This study tested whether adding a special breathing exercise (inspiratory muscle training) to a standard 3-week pulmonary rehab program helps reduce shortness of breath more than rehab alone. It included 38 COPD patients with normal breathing muscle strength. The goal was to see…

This completed study enrolled 6 adults with systemic lupus erythematosus (SLE) to collect blood, urine, saliva, stool, and tissue samples over time. The goal was to find biological markers that could predict when a patient's disease might flare up or how they might respond to tre…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study compared a non-invasive device (ClearSight) with a standard invasive method (transpulmonary thermodilution) for measuring heart function in 42 ICU patients with shock or low cardiac output. The goal was to see if the non-invasive device could be used routinely. Researc…

This study followed 39 lung cancer patients who received radiation therapy to see how it affected their breathing. Researchers measured lung volume and gas exchange capacity before and after treatment, looking for a 20% or greater drop in diffusion capacity at 3 months. The goal …

This study looked at how deep dives (60-120 meters) using closed-circuit rebreathers affect divers' lungs. Twenty experienced divers had lung tests, ultrasounds, and blood samples before, right after, and the day after a dive. The goal was to measure changes in lung capacity and …

This study looked at whether using a gas called MEOPA (laughing gas) to calm children during a lung sample procedure changes the types of bacteria found in their airways. 23 children aged 3 months to 8 years old took part. The goal was to see if the gas affects the accuracy of th…

This completed study with 247 adults aged 18 to 50 explored how body measurements, shoulder muscle strength, and core endurance influence the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) score. Participants performed a push-up-like movement touching one hand to t…

This study looked at injuries from water sports that use foils (like hydrofoil boards) compared to those without. Researchers studied 65 adults who came to the emergency room after a boating accident. The goal was to understand how common foil-related injuries are and what types …

This completed study looked at 116 kidney transplant patients to understand how B cells (a type of immune cell) behave in those who develop donor-specific antibodies or chronic rejection. Researchers analyzed blood samples to find patterns that could serve as early warning signs.…

This study looked at 49 kidney transplant patients to see how two different induction therapies—thymoglobulin and basiliximab—affect B cells, a type of immune cell. Researchers compared the B cell profiles between the two groups and with data from patients who had chronic antibod…

This completed study looked at 70 patients with myeloma or lymphoma who needed stem cell transplants. Researchers compared two drugs, Zarzio and Granocyte, used to stimulate stem cell production before collection. The goal was to see if one drug led to better stem cell grafts. Si…

This study looked at whether a special PET/CT scan, done within two months after treatment, helps doctors make better decisions for patients with advanced cervical cancer. Researchers compared what doctors would decide without the scan versus with it. The study involved 40 patien…

This study looked back at 170 adults with a serious eye infection called endophthalmitis to see if early surgery (within 48 hours) helps vision more than starting with medicine alone. Researchers compared how well people could see one month after treatment. The goal is to find ou…

This study measured how the angle of the uterus changes when the bladder is full versus empty in 200 women who have had at least one child. Researchers used ultrasound to compare the uterine position before and after urination. The goal is to understand if bladder filling can mak…

This study looked at how well handball players can adjust their sense of body position (proprioception) during movement and whether that affects knee injury risk. 41 young, experienced players performed balance tests and cutting maneuvers while researchers measured knee joint for…

This study tested 82 healthy young adults to see how body measurements and physical activity levels affect a shoulder stability test called the CKCUEST. Participants did a timed push-up-like movement, touching one hand to the other. The goal is to better understand what influence…

This study tested whether it is practical for caregivers to send text messages to patients after a suicide attempt. 15 adults who had attempted suicide and their designated caregivers took part. The goal was to see if patients and caregivers found this SMS follow-up acceptable an…

This study looked at whether special rocker sole shoes cause balance problems in people with type 2 diabetes and nerve damage in their feet. 25 adults completed the trial. Researchers measured how much people swayed while standing still in the special shoes.

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…

This study aimed to find the normal ultrasound size of the ulnar nerve at the elbow in 50 healthy adults. Participants had no history of ulnar nerve problems. Researchers measured the nerve's surface area to establish a reference range, which could help diagnose nerve issues in t…

This study looked at how the blood thinner rivaroxaban behaves in people with severe obesity or after bariatric surgery (gastric bypass or sleeve gastrectomy). Researchers gave 67 participants rivaroxaban daily for 8 days and measured drug levels and blood clotting. The goal is t…

This study looks at whether the six-minute stepper test can reliably measure changes in exercise tolerance during a 3-week pulmonary rehabilitation program for people with COPD. Researchers will compare results from the stepper test with the standard six-minute walk test. The goa…

This study tests a portable ultrasound device that measures pelvic tilt, which is important for planning hip replacement surgery. Researchers will check how consistent the measurements are by repeating them on 3 healthy volunteers and then measure pelvic tilt in 30 patients befor…

This study looked at whether doing two 6-minute walk tests at the end of a pulmonary rehabilitation program gives a more accurate measure of exercise capacity in people with COPD. Researchers compared the distance walked in the first and second tests to see if there was a meaning…