HEART FAILURE WITH REDUCED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH REDUCED EJECTION FRACTION explained in plain language.
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MRI scans could help decide who needs a heart defibrillator
Disease control CompletedThis study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Flinders University • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Heart pump patients get new hope from diabetes drug
Disease control CompletedThis study looked at whether a type of diabetes medicine called SGLT2 inhibitors can help people with severe heart failure who also have a mechanical heart pump (LVAD). Researchers measured changes in heart size, weight, and kidney function over 6 months in 32 adults. The goal wa…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Heart failure drug combo may improve valve function
Disease control CompletedThis completed study in 180 heart failure patients compared the effects of taking Entresto alone versus Entresto plus a second drug (empagliflozin) on mitral valve function and heart pumping ability. Participants had heart failure with reduced ejection fraction and some degree of…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Rehab Werida • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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App aims to improve heart failure management through daily tracking
Disease control CompletedThis study tested a mobile app designed to help people with heart failure monitor their blood pressure, weight, and heart rate daily. The app also tracks symptoms and medications, sharing the data with doctors to guide treatment. Researchers wanted to see if using the app leads t…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: University of Michigan • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New heart failure pill shows promise in early trial
Disease control CompletedThis study tested a new drug called JTT-861 in 314 adults with chronic heart failure and reduced pumping ability. Participants took either the drug or a placebo once daily for 12 weeks, alongside their usual heart medications. The goal was to see if the drug improves heart functi…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Akros Pharma Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New initiative aims to boost heart failure drug use in device patients
Disease control CompletedThis study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Ottawa Heart Institute Research Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Heart failure drug may ease tissue congestion without harming blood flow
Disease control CompletedThis study tested whether the diabetes drug ertugliflozin can reduce fluid buildup in the skin and tissues of people with heart failure. 28 adults with reduced heart function took the drug or a placebo for one month each. Researchers measured skin water and sodium content to see …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New heart drug shows promise in early trial
Disease control CompletedThis study tested a new drug called AC01 in 58 adults with heart failure and reduced pumping ability. The goal was to check safety and how the body processes the drug. Participants received either AC01 or a placebo in increasing doses. The study is complete, but results are not y…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: AnaCardio AB • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Gut health breakthrough? probiotic shows promise for heart failure
Disease control CompletedThis study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New drug aims to heal hearts after attack – trial results awaited
Disease control CompletedThis study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardior Pharmaceuticals GmbH • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Potassium binder lets heart patients get full drug benefits
Disease control CompletedThis study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE3 • Sponsor: St George's, University of London • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Heart failure drug shows promise in reducing deadly events
Disease control CompletedThis study tested a drug called sacubitril-valsartan in 60 adults with heart failure and a weak heart pump. The goal was to see if the drug could lower the chance of major heart problems like heart attack, stroke, or death, and improve how well the heart pumps blood. Participants…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Damanhour University • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Heart failure drug tested in african americans: does it work?
Disease control CompletedThis study looked at whether a drug called sacubitril/valsartan helps African American patients with a certain type of heart failure (reduced ejection fraction). Researchers wanted to see if it lowers the chance of death or hospital visits for heart problems. Over 6,500 African A…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Methodist Health System • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Could a Pacemaker-Like device ease heart failure?
Disease control CompletedThis trial tested a device called Barostim neo that stimulates nerves to help control blood pressure in people with advanced heart failure. Over 1,000 participants received either the device or standard medical care. The goal was to see if the device could reduce heart-related de…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: CVRx, Inc. • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New ablation technique tested against standard in heart failure patients
Disease control CompletedThis study compares two types of ablation (pulsed-field vs cryoballoon) for treating atrial fibrillation in people with heart failure and reduced pumping function. Researchers looked back at 700 patients who had their first ablation to see which method works better and is safer. …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: St. Josefs-Hospital Wiesbaden GmbH • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Real-World data shows which heart failure drug may be better
Disease control CompletedThis study looked at health records of 1,249 heart failure patients in Portugal to compare two types of medication: sacubitril/valsartan versus older drugs called ACE inhibitors or ARBs. The goal was to see which treatment better prevents heart failure hospitalizations or death f…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Smart app aims to optimize heart failure meds
Disease control CompletedThis completed Phase 3 trial tested a web application called SmartHF in 225 adults with heart failure and reduced ejection fraction. The app analyzes patient data and gives personalized medication recommendations that patients can share with their doctor. The goal was to see if u…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE3 • Sponsor: University of Michigan • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Could a common gout pill help Veterans' failing hearts?
Disease control CompletedThis study tested whether probenecid, a medicine usually used for gout, can improve heart function and exercise ability in veterans with heart failure. About 99 veterans with a specific type of heart failure took probenecid twice daily for 180 days. Researchers measured changes i…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2, PHASE3 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Could a single pill transform heart failure care for underserved patients?
Disease control CompletedThis pilot study tested a 'polypill' that combines four heart failure medications into one capsule, aiming to make it easier for patients to stick with their treatment. The trial included 35 adults with heart failure and reduced ejection fraction, some of whom also had HIV. Resea…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Heart drug vericiguat shows promise for ACS patients with low ejection fraction
Disease control CompletedThis study looked at whether the drug vericiguat can help people who have had a heart attack or unstable angina and also have a weak heart (ejection fraction below 45%). The main goal was to see if it lowers the chance of dying from heart problems or being hospitalized for heart …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: The First Affiliated Hospital with Nanjing Medical University • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Heart failure patients may benefit from drug optimization clinic after defibrillator implant
Disease control CompletedThis study looked at whether a clinic led by a heart failure nurse could help patients with heart failure get the right medications after getting an implantable defibrillator (ICD) or cardiac resynchronization therapy (CRT). The goal was to see if this approach improved heart fun…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Ratika Parkash • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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One pill to treat heart failure? new study tests simpler approach
Disease control CompletedThis study tested whether a single daily pill containing three heart failure drugs could help people with reduced ejection fraction, especially those with low income or from minority groups. 212 adults took either the polypill or standard separate medications. The goal was to see…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New heart failure pill shows promise in Mid-Stage trial
Disease control CompletedThis Phase 2 trial tested the drug tovinontrine (CRD-750) against a placebo in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug safely lowers a key heart stress marker called NT-proBNP over 12 weeks. The study is complete, and res…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardurion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Heart failure drug combo: start together or one at a time?
Disease control CompletedThis study looked at the safest way to start two heart failure drugs (ARNi and SGLT2i) in 62 adults with a weak heart pump. Researchers compared starting both drugs at the same time versus starting one drug first and adding the other later. The goal was to see which method caused…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Universidade do Porto • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Could a diaphragm pacemaker help failing hearts?
Disease control CompletedThis pilot study tested a device that stimulates the diaphragm in time with the heartbeat to see if it can improve heart function in people with heart failure. 35 participants with reduced ejection fraction received the implant. The study checked for safety and changes in heart s…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: VisCardia Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New strategy aims to get lifesaving heart drugs to more patients
Disease control CompletedThis completed study tested whether special alerts in electronic health records and referrals to pharmacists could help doctors prescribe guideline-recommended heart failure medications more often. Over 4,300 patients with heart failure and reduced ejection fraction took part. Th…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Geisinger Clinic • Aim: Disease control
Last updated Jun 26, 2026 19:11 UTC
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Diabetes drug shows promise for healing hearts after attack
Disease control CompletedThis completed study looked at whether the diabetes drug empagliflozin (Jardiance) can help repair heart damage in diabetic patients who had a major heart attack. 200 participants took either 10 mg or 25 mg of the drug daily for 6 months. Researchers measured changes in heart siz…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 26, 2026 16:15 UTC
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New blood test may spot hidden heart failure in seniors
Diagnosis CompletedThis study aimed to create better diagnostic tools for a type of heart failure called heart failure with preserved ejection fraction (HFpEF), which is common in older adults but hard to diagnose. Researchers tested a combination of five blood markers in 91 participants to see if …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: University Hospital, Montpellier • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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VR goggles calm nerves during heart surgery, study finds
Symptom relief CompletedThis study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Muhammed Kurt • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Can short bursts of intense exercise help heart failure patients?
Symptom relief CompletedThis study looked at whether high-intensity interval training (short bursts of hard exercise) is better than moderate continuous exercise for people with heart failure. Researchers measured nerve activity, blood vessel function, and muscle health in 35 participants. The goal was …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: University of Sao Paulo General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Could a diabetes drug ease heart failure in rare amyloid disease?
Symptom relief CompletedThis study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Computer alert helps doctors prescribe better heart meds
Knowledge-focused CompletedThis study tested a computer alert that pops up in doctors' electronic health records to remind them to prescribe recommended heart failure medications. Over 1,100 patients with a specific type of heart failure (reduced ejection fraction) took part across four health systems. The…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: NYU Langone Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Can patient reports predict heart failure shifts?
Knowledge-focused CompletedThis completed study with over 1,000 participants looked at whether patient surveys and interviews can help doctors spot changes in heart failure. Researchers also collected blood samples to explore links between biology and quality of life. The goal was to see if these tools are…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Intermountain Health Care, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Heart failure Drug's hidden effects revealed in new study
Knowledge-focused CompletedThis study looks at how the drug Sacubitril-Valsartan changes heart function in people with heart failure and reduced pumping ability. Researchers used a non-invasive method to measure heart pressure and volume in 117 participants. The goal is to uncover the mechanisms behind the…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: University of Leipzig • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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AI reads your Heart's electrical signals to predict failure years in advance
Knowledge-focused CompletedThis study tested whether artificial intelligence (AI) could predict a person's risk of developing a specific type of heart failure (HFrEF) up to 5 years in the future, using only a standard ECG. Researchers analyzed data from over 286,000 adults in China and the US. The goal was…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Shanghai Zhongshan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Heart failure drug use tracked in 13,660 remote monitoring patients
Knowledge-focused CompletedThis completed observational study looked at how often heart failure patients in a French nationwide remote monitoring program were prescribed SGLT2 inhibitors between 2021 and 2024. Researchers analyzed data from over 13,600 adults to see how prescription rates changed over time…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Satelia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Heart failure patients learn better with video or text? study finds out.
Knowledge-focused CompletedThis study tested whether heart failure patients learn more from watching videos or reading text about their condition. 130 patients with heart failure took part. They were randomly assigned to video or text modules, then tested on their knowledge. The goal is to find the best wa…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Yale study unlocks secrets of heart failure drug entresto
Knowledge-focused CompletedThis study looked at how the heart failure drug Entresto (LCZ696) lowers blood pressure and helps the body get rid of salt. 46 stable heart failure patients took part. Researchers measured blood pressure and urine sodium levels to understand the drug's effects.
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Mexican heart failure patients studied for better care insights
Knowledge-focused CompletedThis completed study gathered information on 254 Mexican patients with heart failure and reduced ejection fraction. Researchers looked at patient characteristics, treatments, and outcomes in real-world settings. The goal was to understand current medical practices and identify ba…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Medtronic Cardiac Rhythm and Heart Failure • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Heart failure care under the microscope: do german hospitals follow the rules?
Knowledge-focused CompletedThis study checked how well German hospitals and heart failure clinics follow recommended treatments for people with a certain type of heart failure (HFrEF) after a serious episode. Researchers looked at the care of 899 patients to see if guidelines were being used. The goal was …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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Heart failure alert system tested on just 3 pharmacists
Knowledge-focused CompletedThis pilot study tested a computer tool that alerts pharmacists when heart failure patients are not taking their medications as directed. Only 3 pharmacists took part, and the goal was to see if the tool was practical and acceptable. Because it was so small, the results are not e…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Heart failure drug dapagliflozin under Real-World microscope in greece
Knowledge-focused CompletedThis completed study in Greece observed 257 adults with heart failure who were prescribed dapagliflozin as part of their routine care. Researchers tracked how long patients stayed on the drug, any changes in their other heart medications, and how their quality of life changed ove…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Ketone drink shows promise for heart energy in small study
Knowledge-focused CompletedThis study tested whether a 2-week course of a ketone drink could improve how the heart uses energy in 12 people with chronic heart failure. Researchers used PET scans to measure heart fuel consumption and efficiency. The goal was to understand if ketones could be a better energy…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Aarhus University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:07 UTC