HEART FAILURE WITH REDUCED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH REDUCED EJECTION FRACTION explained in plain language.
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New approach boosts use of Life-Saving heart drugs
Disease control CompletedThis study tested new strategies to help doctors prescribe proven heart failure medications to more patients. Over 4,300 adults with heart failure and reduced pumping ability took part. The goal was to increase use of these drugs to lower death rates and prevent hospital stays.
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Geisinger Clinic • Aim: Disease control
Last updated May 17, 2026 04:36 UTC
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New heart procedure matches standard treatment in High-Risk patients
Disease control CompletedThis study looked at 700 people with both atrial fibrillation (an irregular heartbeat) and heart failure (a weak heart pump). It compared two catheter-based treatments that isolate the veins carrying abnormal signals to the heart: a newer method called pulsed-field ablation and a…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: St. Josefs-Hospital Wiesbaden GmbH • Aim: Disease control
Last updated May 17, 2026 04:34 UTC
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Heart failure drug combo: start both at once or one at a time?
Disease control CompletedThis study looked at the safest way to start two common heart failure drugs (ARNi and SGLT2i) in 62 adults with a weak heart pump. Some patients started both drugs at the same time, while others started one drug first and added the second later. The goal was to see which approach…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Universidade do Porto • Aim: Disease control
Last updated May 17, 2026 04:34 UTC
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One pill to rule them all? new combo pill aims to simplify heart failure treatment
Disease control CompletedThis study tested a new combination pill (polypill) that packs four heart failure medicines into one tablet. The goal was to see if it helps people take their medications more regularly compared to taking several separate pills. The study included 35 adults with heart failure, so…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 17, 2026 04:32 UTC
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Could a breathing device help your failing heart?
Disease control CompletedThis study tested a device that stimulates the diaphragm (the main breathing muscle) in people with heart failure and reduced pumping ability. 35 participants received either the active device or a sham. The goal was to see if the device could improve heart function and exercise …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: VisCardia Inc. • Aim: Disease control
Last updated May 17, 2026 04:31 UTC
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Could a diabetes pill help heart failure patients with mechanical hearts?
Disease control CompletedThis study looked at whether a type of diabetes medicine called SGLT2 inhibitors can help people with severe heart failure who also have a mechanical heart pump (LVAD). Researchers measured changes in heart size, weight, and kidney function over six months in 32 adults. The goal …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: University of Chicago • Aim: Disease control
Last updated May 17, 2026 04:16 UTC
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Heart failure drug may drain excess fluid without harming blood flow
Disease control CompletedThis study tested whether ertugliflozin, a diabetes drug, can reduce fluid congestion in people with heart failure. 28 adults with reduced heart pumping function took the drug or a placebo in a crossover design. The goal was to see if the drug removes fluid from tissues without l…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated May 17, 2026 04:15 UTC
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Heart drug vericiguat put to the test in 149 patients after heart attack
Disease control CompletedThis study looked at whether the drug vericiguat helps people who recently had a heart attack (acute coronary syndrome) and have a weak heart pump (ejection fraction below 45%). The main goal was to see if it lowers the chance of dying from heart problems or being hospitalized fo…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: The First Affiliated Hospital with Nanjing Medical University • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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New heart failure drug shows promise in major trial
Disease control CompletedThis study tested a new medicine called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if it safely lowers a key heart stress marker (NT-proBNP) compared to a placebo. Participants took the drug or placebo for 12 weeks, and …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardurion Pharmaceuticals, Inc. • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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Potassium binder may unlock lifesaving heart drugs for kidney patients
Disease control CompletedThis study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of standard heart medications (RAAS inhibitors) that are often limited by high potassium levels. 112 adults with stable kidney diseas…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE3 • Sponsor: St George's, University of London • Aim: Disease control
Last updated May 12, 2026 13:39 UTC
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Could a common diabetes pill ease rare heart condition?
Disease control CompletedThis study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking ability, and heart stress levels over…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated May 11, 2026 20:37 UTC
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New heart drug AC01 shows promise in early trial
Disease control CompletedThis study tested a new medicine called AC01 in 58 adults with a type of heart failure where the heart pumps less blood than normal. The goal was to check if the drug is safe and how the body processes it. Participants received either AC01 or a placebo, and researchers monitored …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: AnaCardio AB • Aim: Disease control
Last updated May 04, 2026 16:30 UTC
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Gut health boost may help heart failure patients move more
Symptom relief CompletedThis study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise capacity and blood vessel function in people with chronic heart failure. Ten adults with heart failure and signs of inflammation took either the probiotic or a pla…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Symptom relief
Last updated May 17, 2026 04:36 UTC
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Heart failure drug use tracked in 13,660 remote monitoring patients
Knowledge-focused CompletedThis study examined how often adults with chronic heart failure were prescribed SGLT2 inhibitors (a type of medication) when they joined a nationwide remote monitoring program in France between 2021 and 2024. Researchers looked at trends over time and factors like patient charact…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Satelia • Aim: Knowledge-focused
Last updated May 17, 2026 04:14 UTC
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Ketone drink study probes heart fuel efficiency in failure patients
Knowledge-focused CompletedThis study looked at how a 2-week ketone supplement changes the way the heart uses energy in 12 people with chronic heart failure. Researchers used special scans to measure heart fuel consumption and efficiency. The goal was to understand the heart's energy process, not to test a…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Aarhus University Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 04:14 UTC
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AI reads your Heart's electrical signals to predict failure years in advance
Knowledge-focused CompletedThis study used artificial intelligence to analyze electrocardiograms (ECGs) from nearly 287,000 adults in China and the United States. The goal was to see if the AI could predict who might develop a type of heart failure (with reduced pumping ability) up to five years before sym…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Shanghai Zhongshan Hospital • Aim: Knowledge-focused
Last updated May 14, 2026 12:03 UTC
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Can a computer nudge help heart failure patients get better meds?
Knowledge-focused CompletedThis small pilot study tested whether electronic alerts in health records could help pharmacists remind heart failure patients to take their medications as prescribed. Only 3 pharmacists took part, and the goal was to see if the system was practical and useful. The study did not …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 12, 2026 13:39 UTC
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Heart Drug's hidden powers revealed: study probes how Sacubitril-Valsartan boosts pumping
Knowledge-focused CompletedThis study looked at how Sacubitril-Valsartan, a medicine for heart failure, helps the heart pump better. Researchers measured heart function in 117 adults with weak hearts using a non-invasive method. The goal was to understand the underlying mechanisms behind the drug's benefit…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: University of Leipzig • Aim: Knowledge-focused
Last updated May 11, 2026 20:52 UTC