HEART FAILURE WITH REDUCED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH REDUCED EJECTION FRACTION explained in plain language.
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Could continuing a common heart drug before surgery save lives?
Disease control Not yet recruitingThis trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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One pill to rule them all: new study aims to simplify heart failure treatment
Disease control Not yet recruitingThis study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Smarter heart pacing could cut hospital stays for heart failure patients
Disease control Not yet recruitingThis study tests a newer, more natural pacing method for people with heart failure and electrical problems in the heart. The approach uses the heart's own conduction system to improve coordination between chambers. Researchers will track patients for two years to see if this meth…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: University of Pecs • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Can heart failure patients ditch their pills? new study aims to find out
Disease control Not yet recruitingThis pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Kyungsub Song • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Heart failure drug vericiguat faces new test in tricuspid regurgitation patients
Disease control Not yet recruitingThis study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Daejeon St. Mary's hospital • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Stents plus drugs vs. drugs alone: which is better for heart failure?
Disease control Not yet recruitingThis study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Nanjing First Hospital, Nanjing Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Heart pump auto mode tested in High-Risk procedure
Disease control Not yet recruitingThis pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: Rayyan Hemetsberger • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New clinic aims to tackle heart failure and meth addiction together
Disease control Not yet recruitingThis pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Can a blood pressure pill help heart failure patients get the meds they need?
Disease control Not yet recruitingThis pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2, PHASE3 • Sponsor: Ottawa Heart Institute Research Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Simple mouthpiece could ease heart strain in sleep apnea patients
Disease control Not yet recruitingThis study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: National University Hospital, Singapore • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Can a common amino acid boost heart function in failure patients?
Disease control Not yet recruitingThis phase 2 trial tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment improves heart function and symptoms. Researchers will enroll 200 stable heart failure patients with low ejection fraction (under 40%). Participants will receive either L…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE2 • Sponsor: German University in Cairo • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Lab-grown heart cells injected into failing hearts: a new hope?
Disease control Not yet recruitingThis early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: Heartseed Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Heart failure and AF: which procedure works best?
Disease control Not yet recruitingThis study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: University of British Columbia • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Can a common heart drug improve how the heart relaxes?
Disease control Not yet recruitingThis study looks at whether the drug sacubitril/valsartan (Entresto) can improve the heart's ability to relax in people with heart failure and reduced pumping strength. Researchers will use ultrasound to measure changes after six months of treatment. The study involves 70 adults …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Assiut University • Aim: Disease control
Last updated Jun 26, 2026 13:42 UTC
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Sauna sessions may ease heart failure symptoms and reduce water pills
Symptom relief Not yet recruitingThis study looks at whether adding sauna therapy to standard cardiac rehabilitation can help people with heart failure feel less congested and possibly lower their dose of water pills (diuretics). About 46 adults with heart failure and reduced pumping ability will be randomly ass…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: NA • Sponsor: BAUDRY Guillaume • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Stiff arteries may hold key to heart failure progression
Knowledge-focused Not yet recruitingThis study looks at how the stiffness and function of blood vessels change in people newly diagnosed with heart failure. Researchers will measure these factors at the start, after a few weeks of standard medication, and after a cardiac rehab program. All tests are non-invasive an…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Sponsor: Coventry University • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC
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PICTURES MAY BOOST HEART DRUG ADHERENCE IN NEW STUDY
Knowledge-focused Not yet recruitingThis study tests a simple idea: showing heart failure patients easy-to-understand pictures of how their medications can help them live longer and stay out of the hospital. About 100 adults with heart failure will receive these visual aids along with their usual care. Researchers …
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: EARLY_PHASE1 • Sponsor: University of Giessen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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New study aims to crack the code on Hard-to-Treat sleep apnea in heart failure
Knowledge-focused Not yet recruitingThis study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC