GASTRIC ADENOCARCINOMA

This early-phase trial tests whether a shorter course of chemoradiation (2 weeks instead of 5) followed by standard chemotherapy is safe and effective for people with stomach cancer who will have surgery. About 25 participants will receive the shortened radiation along with chemo…

This study is testing whether a drug called tucatinib can be safely combined with other cancer medicines (trastuzumab, chemotherapy, and pembrolizumab) to treat HER2-positive cancers of the digestive system. About 40 adults with advanced stomach, bowel, or gallbladder cancer are …

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss surgery or cancer surgery on the stomach or esophagus. About 180 adults who develop such leaks will be randomly assigned to get either the new stent, …

This study tests whether giving heated chemotherapy directly into the abdomen during surgery can prevent stomach cancer from returning in the belly lining. It includes 16 adults with stomach or gastroesophageal junction cancer at high risk of recurrence. The approach aims to kill…

This study tested whether using a person's genetic information to adjust the dose of a chemotherapy drug (irinotecan) could help patients with advanced stomach or esophageal cancer. The goal was to see if this personalized approach could make surgery more successful by shrinking …

This study tests a new drug called SKB264 in people with advanced solid tumors (like lung, breast, or ovarian cancer) that have not responded to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 1,410 participants will receive t…

This study tests whether adding chemotherapy to an immunotherapy drug (atezolizumab) works better than immunotherapy alone for patients with a specific genetic type of stomach or gastroesophageal junction cancer (MSI-H/dMMR). About 240 adults with cancer that hasn't spread far wi…

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with chemotherapy and radiation before surgery can safely treat stomach cancer. About 32 adults with resectable gastric or gastroesophageal junction cancer will receive this combination. The goa…

This study tests whether a combination of targeted drugs (trastuzumab deruxtecan, capecitabine, and durvalumab) can shrink HER2-positive stomach or gastroesophageal junction cancer before surgery and prevent return after surgery. About 64 adults with untreated, advanced but not s…

This study tests whether adding the drug ASKB589 to standard chemotherapy and immunotherapy can help people with advanced stomach or gastroesophageal junction cancer live longer without their disease getting worse. About 780 adults whose tumors have a specific marker (CLDN18.2) w…

This study is for people with specific types of stomach cancer (mismatch repair deficient or Epstein-Barr virus positive) that can be surgically removed. It tests whether giving the immunotherapy drug pembrolizumab before and after standard chemotherapy and radiation can help pre…

This study tests if a less invasive surgery (using one or a few small cuts) is safe and effective for advanced stomach cancer. About 108 participants will undergo this procedure to see if it can remove enough lymph nodes and reduce complications. The goal is to improve recovery w…

This study looks at whether a special recovery plan helps people with stomach cancer feel better and leave the hospital sooner after surgery. About 52 patients with early to advanced stomach cancer will take part. The plan aims to reduce pain and nausea, help the bowels work soon…

This study examines whether men and women with stomach cancer receive different care in Germany. Researchers will analyze data from 75,000 patients treated between 2017 and 2021, looking at survival rates, complications, and treatment approaches. The goal is to identify gender-ba…

This study looks at how much it costs to add an upper stomach exam (endoscopy) to routine colon cancer screening, and the overall economic impact of treating stomach cancer. Researchers will review hospital records from about 250 people to understand cancer stages, treatments, an…

This study follows 208 adults in France who are already receiving nivolumab combined with chemotherapy as their first treatment for advanced or metastatic stomach, gastroesophageal junction, or esophageal cancers. The goal is to see how long patients live and how the disease resp…

This study looks at whether using a small camera to look inside the belly (laparoscopy) can help doctors choose the best treatment for people with stage III stomach cancer. About 968 patients will take part. The goal is to see if this extra step improves survival and helps find c…