Could a common ED drug boost chemo for stomach cancer?

NCT ID NCT05709574

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding tadalafil (a drug used for erectile dysfunction) to standard chemotherapy can help shrink stomach or gastroesophageal junction tumors before surgery. Ten adults with resectable cancer will receive tadalafil alone for two weeks, then combined with chemo for about eight weeks. The goal is to see if this approach is safe and reduces immune cells that block the body's ability to fight cancer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Arizona Cancer Center at UMC North/University Medical Center

    RECRUITING

    Tucson, Arizona, 85719, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••