GASTRIC ADENOCARCINOMA

This study tests a new drug, BHB810, in adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. The drug is given as an IV infusion every two weeks. The main goals are to check safety, find the best dose, and see if it can s…

This study tests whether adding the drugs SHR-1701 and apatinib to standard chemotherapy before surgery can improve outcomes for people with advanced stomach or gastroesophageal junction cancer. About 80 adults with resectable tumors will be randomly assigned to one of two treatm…

This study tests a combination of three drugs (disitamab vedotin, tunlametinib, and a PD-1 antibody) in people with advanced HER2-positive stomach cancer who have already tried at least two other treatments. The goal is to see if this combo can shrink tumors and how safe it is. P…

This study tests two different drug combinations given before surgery for people with a specific genetic type of stomach or gastroesophageal junction cancer (dMMR/MSI-H). The goal is to see if these combinations can completely eliminate the tumor before surgery. About 30 adults w…

This study tests whether injecting a new treatment called RP2 directly into stomach or esophageal tumors, along with standard chemotherapy (FLOT), is safe and works better than chemo alone before surgery. About 34 people with stage 2 or higher non-metastatic cancer will take part…

This study tests a new drug called denikitug, alone or with other treatments, in people with advanced HER2-negative stomach, gastroesophageal junction, or esophageal cancer that has spread or come back after initial therapy. About 120 participants will be randomly assigned to rec…

This is the first human study of an experimental oral drug called ACC-1898 for adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and understand how the body processes the drug. Participants will take dail…

This study tests if a smartwatch-guided exercise program helps cancer survivors feel less tired after finishing chemotherapy. About 98 adults with certain cancers (breast, colorectal, ovarian, pancreatic, stomach) will either follow the exercise program or receive standard care. …

This study follows 3,000 adults aged 40 and older who are at high risk for stomach cancer. Participants provide a stool sample and undergo an initial stomach exam. Researchers will track who develops stomach cancer over 3, 5, and 10 years to see if a simple stool test can help pr…

This early-phase study tests whether a magnetic tracer (FerroTrace) plus a fluorescent dye can safely help identify lymph nodes where stomach cancer may have spread. About 20 adults with early-stage gastric cancer will receive the injection before their scheduled stomach removal …

This study will look at 4,000 adults aged 40 and older in India who are already scheduled for a stomach scope. Using high-definition cameras, doctors will check for early stomach cancer and pre-cancerous changes. The goal is to learn how common these conditions are and improve ea…