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New Pre-Surgery combo aims to boost cancer fight in stomach and esophageal tumors

NCT ID NCT07507968

Not yet recruiting Disease control Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests giving a combination of chemotherapy (FLOT) and an immunotherapy drug (durvalumab) before surgery, followed by more durvalumab after surgery, for people with stomach or esophageal cancer that can be removed. The goal is to see if this approach leads to a complete disappearance of cancer cells in the removed tissue. About 101 adults with locally advanced cancer will take part.

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Conditions

The condition(s) this trial relates to.

esophageal adenocarcinoma gastric adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGOGASTRIC ADENOCARCINOMA

Contacts and locations

Locations

  • Caritas Klinikum Saabrücken

    Saarbrücken, Germany

  • Charité Berlin

    Berlin, Germany

  • HOPE Hamburg Eppendorf

    Hamburg, Germany

  • Hospital Clínico Universitario de Valencia Servicio de Oncología Médica

    Valencia, Spain

  • Hospital General Universitari Vall d'Hebron (HUVH)

    Barcelona, Spain

  • Hospital Regional Universitario de Jaén

    Jaén, Spain

  • Hospital Regional Universitario de Málaga

    Málaga, Spain

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Spain

  • Hospital Universitario Central de Asturias. Oncología Médica

    Oviedo, Spain

  • Hospital Universitario Miguel Servet Oncología Médica

    Zaragoza, Spain

  • Hospital Universitario Virgen de las Nieves de Granada

    Granada, Spain

  • Hospital Universitario de Navarra (HUN)

    Pamplona, Spain

  • Klinikum Essen Mitte

    Essen, Germany

  • Krankenhaus Nordwest

    Frankfurt am Main, Germany

  • Marien Hospital Herne

    Herne, Germany

  • NCT Heidelberg

    Heidelberg, Germany

  • Nürnberg Klinikum Nord

    Nuremberg, Germany

  • RKH Klinikum Ludwigsburg

    Ludwigsburg, Germany

  • TU München

    München, Germany

  • UKE Hamburg

    Hamburg, Germany

  • Universitätsklinikum Halle (Saale)

    Halle, Germany

  • Universitätsklinikum Köln

    Cologne, Germany

  • Universitätsklinikum Leipzig

    Leipzig, Germany

  • Universitätsklinikum Marburg

    Marburg, Germany

  • Universitätsklinikum Ulm

    Ulm, Germany

  • Universitätsmedizin Göttingen

    Göttingen, Germany

  • Universitätsmedizin Mainz

    Mainz, Germany

  • Universitätsmedizin Mannheim

    Mannheim, Germany

  • Vivantes Klinikum Neukölln

    Berlin, Germany

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