New drug combo aims to outperform immunotherapy in Hard-to-Treat stomach cancer
NCT ID NCT07716449
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether an experimental drug called QLS31905, combined with chemotherapy (CAPOX), works better than the current immunotherapy drug sintilimab plus the same chemotherapy for people with advanced gastric or gastroesophageal junction cancer. The study includes patients whose tumors have a specific protein (CLDN18.2) and low PD-L1 levels, a group that often does not benefit from standard immunotherapy. Researchers will measure how long participants live without their cancer worsening.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of an experimental drug called QLS31905 and chemotherapy (CAPOX: capecitabine and oxaliplatin)
- What this could lead to
- If successful, this could provide a new first-line treatment option for people with a specific type of advanced gastric cancer that does not respond well to current immunotherapy.
- What could go wrong
- This is an early-stage Phase 3 trial, so results are not yet known. The experimental combination may not prove more effective or safer than the existing treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for GASTRIC ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Triple-Drug attack slow down stomach cancer?
- Can a Three-Drug cocktail shrink stomach tumors before surgery?
- Can a less extensive stomach surgery preserve appetite better?
- Triple-Drug cocktail aims to wipe out stomach tumors before surgery
- Breath of life: new test could sniff out gut cancers before they spread
- Drug cocktail aims to shrink Hard-to-Treat stomach cancers