DIABETES

This study tests a new insulin, GZR4, against another long-acting insulin (Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also …

This early-phase trial tests whether transplanting insulin-producing cells into the front chamber of the eye can help control diabetes. Two participants with severe vision loss in one eye will receive the cells through a small incision, along with immunosuppressive eye drops to p…

This study looks at whether a program that combines clinic support and digital health coaching can improve diabetes and blood pressure control in low-income patients. About 600 adults with uncontrolled diabetes or high blood pressure will take part. The goal is to see if better a…

This study gives free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easy access to these devices helps lower blood sugar and improves quality of life. Participants wear the sensor for 14-day periods and report o…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve their heart health. Participants will receive either the full program (peer support and help finding resources) or basic …

This study tests a program that helps primary care clinics connect diabetes patients in rural Kentucky with community organizations to meet basic needs like food, housing, and transportation. About 12,000 adults with diabetes will take part. The goal is to see if this approach im…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after starting insulin in the hospital helps manage blood sugar better than standard finger-stick testing. About 150 adults with type 1 or type 2 diabetes who are new to insulin will be randomly …

This study looks at whether one type of anesthesia (propofol) can lower the chance of confusion or delirium after surgery in older adults with diabetes, compared to another (sevoflurane). About 450 people aged 60 and older having non-heart surgery will take part. The goal is to f…

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. Researchers will compare samples from people with type 1 or type 2 diabetes, those at high risk, and healthy volunteers. The goal is to better understand how dia…

This study aims to see if stem cells from taste buds can be turned into insulin-producing cells, which could lead to new diabetes treatments. Researchers will take tiny tissue samples from the tongues of 250 healthy adults. The goal is to grow these cells in a lab and test if the…

This study looks at whether adding regular physical health checkups to mental health care helps find hidden diseases like heart problems, diabetes, or cancer in people with serious mental illness. About 2,800 adults in Denmark will get these checkups, and their results will be co…

This study is collecting genetic and health information from 3,000 people to help doctors choose the right medications and avoid side effects. Participants include those taking five or more medications, or those on blood pressure or depression drugs. The goal is to learn how gene…

This study explores how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It also tests whether a program that includes healthy habits, exercise, and mental activities can help prevent or slow down memory decline. About 420 people from diabetes clinics in Den…

This study explores whether using advanced insulin delivery systems early after a type 1 diabetes diagnosis can protect brain development in children aged 5 to 7. Researchers will compare brain scans and thinking skills among kids using different treatments and those without diab…

This study aims to find out if people with diabetes lose more vitamin C in their urine than those without diabetes, which could explain why diabetics often have lower vitamin C levels. Researchers will measure vitamin C in blood and urine from 5,000 adults aged 18-65, both with a…

This study looks at how your genes and your environment work together to affect your health. Researchers are collecting health and lifestyle information from 25,000 adults to better understand diseases like diabetes, heart disease, and asthma. The goal is not to test a new treatm…