CHOLANGIOCARCINOMA

This early-stage study is testing whether adding two experimental treatments—deep heat therapy and a special type of radiation—to standard chemotherapy and immunotherapy is safe and feasible for people with advanced bile duct cancer that cannot be removed by surgery. The goal is …

This study is testing whether adding immunotherapy drugs to standard chemotherapy is safe and effective for people with advanced bile duct cancer. It will involve about 50 adult patients who cannot have surgery to remove their cancer. The goal is to see if this combination can be…

This early-stage study is testing a new radioactive cancer drug called LY4337713 in adults with advanced solid tumors that have spread. The drug is designed to seek out and deliver radiation directly to cancer cells that have a specific protein marker called FAP. Researchers will…

This is the first study in humans of an experimental drug called MGC028 for people with advanced solid tumors that have stopped responding to standard treatments. Researchers will test increasing doses in about 124 participants to find the highest safe amount and check for side e…

This study is testing a drug called tivozanib for people with advanced bile duct cancer (cholangiocarcinoma) that cannot be removed by surgery and has continued to grow after initial chemotherapy. The main goals are to find a safe dose and see if the drug can shrink or stop the g…

This study is testing if a special surgical glue can prevent dangerous fluid leaks after major pancreas cancer surgery. About 194 patients having surgery for pancreatic or related cancers will be randomly assigned to receive the standard surgical connection or the same connection…

This is a very early-stage study to test the safety of a new drug called GV20-0251 in adults with advanced solid tumors that have progressed despite standard treatments. The main goal is to find a safe dose by giving the drug to small groups of patients at different levels. It is…

This study is testing a new four-drug combination for people with advanced bile duct cancer who haven't had prior treatment. About 39 participants will receive chemotherapy plus two newer drugs to see if this mix can better control the cancer. The main goal is to measure how long…

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study is testing whether a drug called ivosidenib can help prevent cancer from returning in people with a specific type of bile duct cancer who have already had surgery and chemotherapy. The trial will involve about 40 patients who have a particular genetic mutation (IDH1) i…

This study is testing whether adding a new immune-stimulating drug called PDS01ADC to a specialized liver cancer treatment can better control advanced cancers that have spread to the liver. The treatment involves surgically placing a pump that delivers chemotherapy directly to th…

This study is collecting real-world information on how well the targeted drug ivosidenib works for people with advanced bile duct cancer who have a specific genetic mutation (IDH1 R132) and have already tried at least one other treatment. Researchers will follow 100 patients in G…

This study is testing if adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) helps people with a type of bile duct cancer in the liver stay cancer-free longer after surgery. The treatment is given both before and after the operation. R…

This early-stage study is testing a new drug called APL-5125 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and see if the drug can shrink tumors, especially in colorectal canc…

This study is testing whether a new drug called GNS561 works better when combined with an existing drug, trametinib, for people with advanced bile duct cancer that has a specific genetic change (KRAS mutation) and has stopped responding to standard chemotherapy. The main goals ar…

This study is gathering more information on the safety and effectiveness of the drug ivosidenib for adults with advanced bile duct cancer (cholangiocarcinoma) who have already tried at least one other treatment. All participants will take ivosidenib pills daily. The main goal is …

This study is testing whether taking spirulina tablets can help protect the liver and help it heal faster after surgery to remove part of it for bile duct cancer. Researchers will give 30 participants either spirulina or a placebo pill for 3 weeks before and 3 weeks after their o…

This study is testing if a new combination of chemotherapy drugs works better than the current standard for advanced bile duct cancer when the first treatment stops working. It combines a pill called trifluridine/tipiracil with an IV drug called oxaliplatin. The goal is to see if…

This study is testing whether adding a new drug called BOLD-100 to standard FOLFOX chemotherapy can better control advanced cancers of the colon, pancreas, stomach, and bile ducts. Researchers will first find the safest dose of BOLD-100 and then see if the combination helps slow …

This early-stage study is testing the safety and initial effectiveness of combining two targeted cancer drugs, pemigatinib and afatinib, in people with advanced solid tumors that have specific genetic changes and have stopped responding to standard treatments. The main goals are …

This study is testing a new combination treatment for people with advanced bile duct cancer. It combines a specialized form of targeted radiation with two immunotherapy drugs and standard chemotherapy. The main goals are to see if this combination is safe and effective at control…

This study aims to develop a simple blood test to detect six different gastrointestinal cancers earlier than current methods. Researchers will analyze blood samples from 1,000 people, including those with cancer and healthy controls, to find tiny genetic signals that indicate can…

This study is testing a new type of PET scan that uses a special tracer called 18F-FSPG. The goal is to see if this scan can better find and map out liver cancer in patients who are scheduled for surgery or a liver transplant. Researchers will compare this new scan to current sta…

This study is testing a new way to diagnose a hard-to-detect bile duct cancer called cholangiocarcinoma. Researchers will analyze proteins in patients' bile fluid to see if this 'liquid biopsy' can provide a faster, more accurate diagnosis than current methods. The goal is to hel…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study aims to understand how the cancer drug olutasidenib affects how the body processes other medications. Researchers will measure blood levels of several test drugs in 16 adult patients with specific genetic mutations in their cancers. The goal is to learn about potential…

This study aims to understand why some patients with advanced bile duct cancer respond better than others to a specific two-drug treatment (lenvatinib plus pembrolizumab). Researchers will follow 100 patients receiving this treatment in real-world clinics to see how well it works…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study aims to better understand Primary Sclerosing Cholangitis (PSC), a serious liver disease, and related cancers. Researchers will collect bile samples from 300 people with and without PSC during routine medical procedures. They will use these samples to grow tiny 3D liver…

This study is creating a large collection of blood, saliva, stool, and other samples from people with rare liver diseases and healthy volunteers. The goal is to help researchers better understand diseases like Primary Sclerosing Cholangitis (PSC) and Primary Biliary Cholangitis (…

This study aims to understand why some liver cancer patients respond to immunotherapy while others do not. Researchers will collect blood, tissue, and health data from 500 adults with liver cancer who have had or will have immunotherapy. By analyzing this information over time, t…

This study aims to better understand how inherited changes in the BAP1 gene increase the risk for several types of cancer, including eye and skin melanoma, kidney cancer, and mesothelioma. Researchers will enroll 500 participants who have a personal or strong family history of th…

This study collects tumor and normal tissue samples from patients who are already scheduled for a biopsy or surgery for a solid tumor. The goal is to use these samples in research to discover new targets for future cancer therapies. No experimental treatments are given as part of…

This study aims to discover what causes bile duct and gallbladder cancers and why treatments work differently for different people. Researchers will compare 1,500 participants, including cancer patients, healthy people, and people with liver disease. They will collect blood and t…

This study is testing a new laboratory method to see if it can predict which cancer treatments will work best for a patient. Researchers will take a sample of a patient's tumor cells from a fluid or tissue biopsy and test how the cells react to different drugs in the lab. The goa…

This study is testing a new way to collect blood for cancer detection. Researchers want to see if taking blood from a vein directly draining the cancer during a biopsy finds more tumor DNA than a standard blood draw from the arm. The goal is to improve the accuracy of blood tests…

This study looks back at the medical records of 1,200 patients who had surgery for various cancers. Researchers want to understand how often and why some patients develop voice problems or throat injuries after having a breathing tube placed during anesthesia. By identifying the …