CHOLANGIOCARCINOMA

This study tested whether the drug E7090 could help people with advanced bile duct cancer that had a specific genetic change (FGFR2 fusion) and had stopped responding to standard chemotherapy. The trial involved 63 participants and measured how much their tumors shrank and how lo…

This study tested whether a specific pump and catheter system was a safe way to deliver chemotherapy directly into the liver for patients with colorectal cancer or cholangiocarcinoma that had spread to the liver. The goal was to see if this method could control the cancer in the …

This first-in-human study tested a new drug called Cabotamig in 33 adults with advanced gastrointestinal cancers that had stopped responding to standard treatments. The main goals were to check the drug's safety, see how the body processes it, and look for early signs that it mig…

This early-stage trial tested a new immunotherapy called ELI-002 in 25 people with pancreatic, colorectal, lung, and other cancers that have specific KRAS mutations. The treatment was given after standard therapy to target any remaining cancer cells and prevent recurrence. Resear…

This first-in-human study tested a new oral drug, AG-120, designed to target a specific genetic flaw (IDH1 mutation) found in several advanced solid tumors, including certain brain, bile duct, and bone cancers. The main goals were to find the safest and most effective dose and to…

This study tested a new, highly targeted drug called RLY-4008 in people with advanced cancers, focusing on bile duct cancer. The main goals were to find a safe and effective dose and to see if the drug could shrink tumors in patients whose cancers have a specific genetic change c…

This study tested a new three-part treatment for advanced bile duct cancer that cannot be removed by surgery. It combined a targeted chemotherapy delivered directly to the liver, a drug that blocks cancer growth signals, and an immunotherapy drug. The goal was to see if this comb…

This study aimed to find the best length of immunotherapy treatment for people with advanced cancers. It enrolled 161 patients whose cancer had remained stable after one year of treatment. Researchers randomly assigned participants to either stop their immunotherapy or continue i…

This study compared two different ways to take a tissue sample (biopsy) to diagnose a specific type of bile duct cancer where it enters the liver. Researchers enrolled 200 adults with imaging that suggested this cancer. They wanted to see which biopsy method was more accurate, sa…

This study tested a new blood test to see if it could accurately detect whether a type of liver cancer called intrahepatic cholangiocarcinoma (bile duct cancer) had spread to nearby lymph nodes before a patient's surgery. The goal was to help doctors decide the best surgical plan…

This study tested a new type of PET scan designed to better detect and locate gastrointestinal cancers. The scan uses a special tracer that attaches to a protein often found in these tumors. Researchers compared the scan results to tissue samples from 109 patients to see how accu…

This study aimed to gather more information about how well a specific biopsy needle works during a common diagnostic procedure. Doctors used the EchoTip AcuCore needle to collect tissue samples from 183 adults with various cancers or pancreatic conditions. The main goal was to se…

This phase II trial studies how well infigratinib works in treating solid tumors that have spread to other places in the body (advanced or metastatic) in patients with FGFR gene mutations such as FGFR1-3 gene fusions or other FGFR genetic alterations. Mutations are any changes in…