CHOLANGIOCARCINOMA

This study tests whether using a 3D-PTA drug sensitivity test to choose chemotherapy after surgery can help people with stage II/III bile duct cancer live longer without the cancer returning. About 98 adults who have had their tumor removed will be randomly assigned to either sta…

This study tests whether a combination of two drugs, adebrelimab and S-1, can help prevent bile duct cancer from returning after surgery. About 40 adults who had their cancer completely removed will receive the treatment for several months. Researchers will track how many stay ca…

This study tests two drugs together (pucotenlimab and becotatugvedotin) in about 60 people with advanced bile duct cancer that has not responded to prior treatment. The main goal is to see if the combination can shrink tumors. Researchers will also track how long the benefit last…

This study compares two ways to drain bile in people with bile duct cancer causing a blockage. One method places a tube across the bile duct opening into the intestine, while the other uses a metal stent above the opening. The goal is to see which method causes fewer infections a…

This study collects blood, tissue, and other samples from 300 adults with liver, bile duct, or pancreatic tumors, as well as from people with benign conditions and healthy volunteers. No experimental treatments are given—samples are taken during routine care. The goal is to creat…

This study will follow 1,000 adults who have liver or bile duct surgery at San Jacopo Hospital in Pistoia. Researchers will track complications, survival, and cancer recurrence for up to 5 years. The goal is to better understand how patients recover and their long-term outcomes a…

This study looks at whether an improved endoscopic ultrasound (EUS) procedure can better find cancer in lymph nodes of people with bile duct cancer before they have surgery. About 250 adults with certain types of bile duct cancer that might be removable will get this special ultr…

This study involves 70 patients with various cancers who are receiving biotherapy drugs. Researchers want to find the highest safe concentration of these drugs to use in skin allergy tests, so they can better diagnose allergic reactions. The goal is to create clear guidelines for…

This study looks at whether blood tests that detect cancer DNA (ctDNA) and patient-reported quality of life can help predict how bile duct cancer will progress and how well treatment is working. Researchers will collect blood samples and questionnaires from 300 patients with cura…