New combo aims to stall bile duct cancer after chemo

NCT ID NCT06441747

Recruiting now Disease control Sponsor: Australasian Gastro-Intestinal Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether combining two drugs—durvalumab (an immunotherapy) and olaparib (a targeted therapy)—can help keep advanced bile duct cancer from growing after initial chemotherapy. The study will enroll 40 adults with locally advanced or metastatic cholangiocarcinoma who have not progressed on first-line treatment. Participants will receive the drug combination for up to 24 months, and researchers will monitor cancer progression, survival, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab (Imfinzi) and olaparib (Lynparza)
What this could lead to: If successful, this combination could offer a new maintenance option to help keep advanced bile duct cancer from progressing after initial chemotherapy.
What could go wrong: This is a small, early-phase trial with only 40 participants. The combination may not improve outcomes and could cause side effects like fatigue, nausea, or immune-related reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLANGIOCARCINOMA

Contacts and locations

Locations

Austin Health
RECRUITING

Melbourne, Victoria, 3084, Australia
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, Australia
Monash Medical Centre
RECRUITING

Clayton, New South Wales, 3168, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, 2065, Australia
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia
Wollongong and Shoalhaven District Memorial Hospital
NOT_YET_RECRUITING

Wollongong, New South Wales, 2500, Australia

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