New hope for hard-to-treat bile duct cancer: drug duo targets KRAS mutation
NCT ID NCT05874414
First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 20 times
Summary
This study tests a new combination of two drugs, GNS561 and trametinib, in people with advanced bile duct cancer that has a specific genetic change called a KRAS mutation. The cancer must have worsened after at least one round of standard chemotherapy. The goal is to see if the combination is safe and can shrink tumors. About 74 adults will take part in this early-phase trial.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Froedtert Hospital and the Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Hospital of the University of Pennsylvania
TERMINATEDPhiladelphia, Pennsylvania, 19104, United States
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LA Cancer Network
RECRUITINGLos Angeles, California, 92801, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Orlando Health
RECRUITINGOrlando, Florida, 32806, United States
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Pan American Center for Oncology Trials, LLC
RECRUITINGRio Piedras, Puerto Rico, 00935, Puerto Rico
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Roswell Park Cancer Institute
TERMINATEDBuffalo, New York, 14263, United States
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USC Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University Of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Texas, MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of Virginia Comprehensive Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact
Conditions
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