Vesiculobullous skin disease

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This early-stage study tested a new mRNA vaccine called IN001 for preventing shingles in 150 healthy adults aged 50 to 69. The main goals were to check the vaccine's safety, side effects, and how well it triggers the immune system. Researchers gave different doses to find the bes…

This study followed over 7,500 older adults who received the shingles vaccine to see how well it prevents shingles over many years. Researchers also tested giving extra doses to some participants. The goal was to understand how long protection lasts and whether booster shots are …

This study tested a two-dose shingles vaccine (HZ/su) in 1,430 adults aged 50 and older who had already experienced shingles. The goal was to see if the vaccine could prevent the virus from coming back and to check its safety and immune response. Participants received either the …

This study tested whether giving the RSV vaccine (Abrysvo) and the shingles vaccine (Shingrix) at the same doctor's visit is safe and works as well as giving them separately. About 526 adults aged 50 and older took part. Researchers measured immune responses and tracked side effe…

This study tested whether dupilumab, a drug already used for asthma and eczema, can help people with bullous pemphigoid, a painful blistering skin condition. 106 adults received either dupilumab or a placebo, plus standard steroid treatment. The main goal was to see if more peopl…

This study followed 80 patients with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. Researchers wanted to see how safe and effective rituximab (a drug that targets certain immune cells) is over the long term, compared to standard h…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This early-phase trial tested the drug rituximab in 3 people with ocular cicatricial pemphigoid, a rare autoimmune disease that causes scarring in the eye and can lead to blindness. The goal was to see if the drug could stop further scarring when standard treatments had failed. T…

This study looked at how well the shingles vaccine works and how safe it is for people living with HIV. Researchers compared the immune response based on participants' CD4+ T-cell counts and age. The goal was to provide evidence to help guide vaccination recommendations for this …

This study tested two ways to treat bullous pemphigoid, a severe blistering skin condition. One group used strong steroid creams for 9 months, while the other used steroids plus methotrexate for 4 weeks, then methotrexate alone for 8 months. The goal was to see if the combination…

This study tested whether a single cycle of rituximab can control bullous pemphigoid, a severe blistering skin condition. Eighteen adults with steroid-dependent or relapsing disease were enrolled. Researchers checked disease control weekly for a month and then monthly for two yea…

This study tested whether an oral antibiotic (moxifloxacin) works as well as a standard intravenous (IV) antibiotic (cefazolin) for treating moderate skin infections (cellulitis) in the emergency department. 390 patients with moderate cellulitis were treated either with daily IV …

This phase 2 trial tested avdoralimab, an antibody that blocks a specific immune signal, added to standard steroid cream for bullous pemphigoid—a severe blistering skin condition mostly affecting older adults. Fifteen participants received the combination to see if it leads to co…

This study looked back at 275 pemphigus patients to see how different doses of rituximab affected disease control and relapse. Pemphigus is a rare autoimmune disease that causes painful blisters on skin and mucous membranes. Researchers tracked outcomes like flare-ups, side effec…

This small early-phase trial tested an experimental drug called rigosertib in just 2 people with a rare blistering skin disease (recessive dystrophic epidermolysis bullosa) who also had advanced skin cancer. The goal was to see if the drug could shrink tumors and whether it was s…

This study tested whether an ultrasound-guided nerve block, using a steroid and local anesthetic, could better control pain from shingles and prevent postherpetic neuralgia (long-term nerve pain). 100 adults with acute shingles and moderate to severe pain were randomly assigned t…

This study tested whether a single injection of a patient's own fat-derived stem cells into the penis could improve erectile dysfunction after prostate removal. 70 men who had poor erections for over a year after surgery were enrolled. Half received the stem cell injection, half …

This study compared two common antibiotics, doxycycline and TMP-SMX, for treating uncomplicated skin infections like boils and cellulitis. 269 people aged 9 to 85 took one of the drugs for 7 days. Researchers checked if the infection cleared up early, at the end of treatment, and…

This early study tested a drug called bertilimumab in 11 adults aged 60 and older with newly diagnosed bullous pemphigoid, a condition that causes painful blisters. The main goals were to check safety and see if the drug helps control the disease. While results may show some bene…

This study tested a drug called efgartigimod in 98 adults with moderate to severe bullous pemphigoid, a condition causing painful blisters and itching. The goal was to see if the drug could control the disease and allow patients to stop taking steroids. The trial was split into t…

This study tested whether applying medical-grade honey after bone-anchored hearing aid surgery could prevent skin breakdown better than the usual bacitracin ointment. Seventeen adults were randomly assigned to receive either honey or bacitracin for two weeks after surgery. Resear…

This study tests whether ALIDYA, a gel injected into the skin, can improve the appearance of cellulite on the back of the thighs. Thirty women aged 20 to 45 with mild to moderate cellulite received six weekly treatments. Researchers used photos, ultrasound, and other imaging to m…

This completed Phase 4 study tested multiple doses of Qwo, a drug made from bacterial enzymes, for treating mild to moderate cellulite in adult women. Five participants received injections in their buttocks and thighs over three sessions. The goal was to see if the treatment impr…

This study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…

This study tested a cream paste containing pleuran (a beta-glucan from oyster mushrooms) on 110 children with diaper rash, perioral dermatitis, or neonatal pustulosis. Participants applied the cream 2-3 times daily for up to 2 weeks without other treatments. Researchers measured …

This study tested whether applying insulin directly to skin sores helps them heal faster in people with pemphigus vulgaris, a rare autoimmune blistering disease. Twenty patients each had three similar sores treated with either long-acting insulin, short-acting insulin, or a saltw…

This study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with a rare genetic skin condition called epidermolysis bullosa. The children took CBD syrup three times a day for a month. Researchers measured itch, pain, sleep, and quality of life before and …

This study tested whether a numbing cream (ropivacaine) can reduce severe pain during bath and dressing changes in children and young adults with epidermolysis bullosa, a rare genetic skin condition. Ten participants applied the cream before dressing changes and reported their pa…

This study tested a treatment called Complex Decongestive Therapy (CDT) for people with venous insufficiency, a condition where leg veins struggle to send blood back to the heart. Twenty-one adults received either CDT plus exercises or exercises alone. The goal was to see if CDT …

This pilot study tested whether kinesio taping, applied weekly for four weeks, can improve skin structure and reduce stage II cellulite in women aged 18-45 with normal BMI. Researchers compared a group receiving the tape on thighs and buttocks to a no-treatment control group. The…

This study tested a device that uses tiny needles and radiofrequency energy to treat cellulite on the legs. 48 women received the treatment to reduce the appearance of dimples and improve skin tightness. The goal was to see if the treatment is safe and effective for smoothing ski…

This pilot study tested a portable device called Spincare that sprays a nanofiber dressing onto wounds in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition causing fragile, blistering skin. Six participants with at least six chronic or recurr…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This study looked at whether specialized training for nurses on how to care for children with a rare, severe skin condition called epidermolysis bullosa (EB) can reduce their stress and anxiety. The study involved 19 nurses and nursing assistants at a hospital in France. Research…

This study looked at whether having a dermatologist review a patient's skin condition remotely (teledermatology) could help emergency room doctors correctly identify true cellulitis (a bacterial skin infection) versus pseudocellulitis (a condition that looks like cellulitis but i…

Cellulitis is a painful skin infection that often requires antibiotics, but the ideal treatment length is unknown. This study followed 230 adults hospitalized with cellulitis to identify factors that predict a good recovery, such as medical history and early response to treatment…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This study looked at 48 adults with pemphigus, a rare blistering skin disease, to understand what makes them feel vulnerable during their illness. Researchers used interviews and questionnaires to explore factors like misdiagnosis, differences in how patients and doctors see dise…

This study measured fluid retention in 30 people with bullous pemphigoid who were treated with a strong steroid cream (clobetasol propionate). Researchers used bioimpedance to track changes in body water over 30 days. The goal was to understand if the cream causes fluid buildup a…

This study looked at whether having a dermatologist see patients within 24 hours of being admitted to the hospital for cellulitis (a skin infection) could improve their care. Researchers compared patients who got a dermatology consult to those who only saw their regular hospital …

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study tested two different ways to remove leftover glue from teeth after braces are taken off. 142 people who had braces or clear aligners were split into two groups: one used a special ultrasonic tool, the other used a polishing bur. Researchers checked plaque, bleeding, le…

This study looked at how many medical students have immunity against hepatitis B and varicella-zoster (chickenpox) viruses. Researchers tested 401 students to see their protection levels and vaccination rates. The goal was to understand if current immunization programs are workin…

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at how breathing in simulated wildfire smoke for just one hour affects healthy adults. Researchers measured a blood marker called p-tau, which is linked to memory problems, and tested thinking skills before and after exposure. The goal was to see if short-term s…

This study looked at 30 people with shingles (herpes zoster) to measure levels of inflammatory proteins and nerve-related chemicals in their blood. Researchers wanted to understand how these substances change over time and relate to pain. The study did not test any new treatment,…

This study measured how often sleep disturbances occur in people with bullous pemphigoid, a blistering skin condition that mostly affects older adults. Researchers compared 122 patients to healthy volunteers using a simple insomnia questionnaire. The goal was to understand if sle…