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Could an asthma drug tame this brutal blistering disease?

NCT ID NCT04206553

Completed Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether dupilumab, a drug already used for asthma and eczema, can help people with bullous pemphigoid, a painful blistering skin condition. 106 adults received either dupilumab or a placebo, plus standard steroid treatment. The main goal was to see if more people could achieve long-term remission without needing steroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
dupilumab (Dupixent)
What this could lead to
If successful, dupilumab could offer a new treatment option for bullous pemphigoid, potentially reducing the need for long-term steroids.
What could go wrong
This is a mid-stage trial with only 106 participants. Results may not apply to all patients, and side effects or lack of effectiveness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bullous pemphigoid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BULLOUS PEMPHIGOID

Contacts and locations

Locations

  • Regeneron Study Site

    Scottsdale, Arizona, 85259, United States

  • Regeneron Study Site

    Redwood City, California, 94063, United States

  • Regeneron Study Site

    Farmington, Connecticut, 06030, United States

  • Regeneron Study Site

    Miami, Florida, 33125, United States

  • Regeneron Study Site

    Iowa City, Iowa, 52242, United States

  • Regeneron Study Site

    Boston, Massachusetts, 02116, United States

  • Regeneron Study Site

    Chapel Hill, North Carolina, 27516, United States

  • Regeneron Study Site

    Portland, Oregon, 97239, United States

  • Regeneron Study Site

    Philadelphia, Pennsylvania, 19104, United States

  • Regeneron Study Site

    Murray, Utah, 84107, United States

  • Regeneron Study Site

    Kogarah, New South Wales, 2217, Australia

  • Regeneron Study Site

    Box Hill, Victoria, 3128, Australia

  • Regeneron Study Site

    Bobigny, 93009, France

  • Regeneron Study Site

    Bordeaux, 33000, France

  • Regeneron Study Site

    Lille, 59037, France

  • Regeneron Study Site

    Nice, 06200, France

  • Regeneron Study Site

    Paris, 75010, France

  • Regeneron Study Site

    Rouen, 76031, France

  • Regeneron Study Site

    Münster, North Rhine-Westphal, 48149, Germany

  • Regeneron Study Site

    Mainz, Rhineland-Palatinate, 55131, Germany

  • Regeneron Study Site

    Lübeck, Schleswig-Holstein, 23538, Germany

  • Regeneron Study Site

    Berlin, 10117, Germany

  • Regeneron Study Site

    Buxtehude, 21614, Germany

  • Regeneron Study Site

    Erlangen, 91054, Germany

  • Regeneron Study Site

    Freiburg im Breisgau, 79104, Germany

  • Regeneron Study Site

    Munich, 80802, Germany

  • Regeneron Study Site

    Stuttgart, 70178, Germany

  • Regeneron Study Site

    Hirosaki, 036-8563, Japan

  • Regeneron Study Site

    Ichinomiya, 491-8558, Japan

  • Regeneron Study Site

    Osaka, 545-8586, Japan

  • Regeneron Study Site

    Sapporo, 060-8648, Japan

  • Regeneron Study Site

    Tokyo, 160-8582, Japan

  • Regeneron Study Site

    Krakow, Lesser Poland Voivodeship, 31-147, Poland

  • Regeneron Study Site

    Badalona, Barcelona, 08916, Spain

  • Regeneron Study Site

    Madrid, 28034, Spain

  • Regeneron Study Site 2

    Dresden, Saxony, 01307, Germany

  • Regeneron Study site

    Marburg, 35043, Germany

  • Regeneron Study site

    Kurume, Hukuoka, 830-0011, Japan

  • Regeneron Study site'

    Magdeburg, 39120, Germany

  • Regeneron Study site'

    Ossy, 42-624, Poland

  • Regeneron Study site'

    Wroclaw, 50566, Poland

  • Regeneron study Site

    Birmingham, Alabama, 35233, United States

  • Regeneron study Site

    Orlando, Florida, 32827, United States

  • Regeneron study Site

    Ann Arbor, Michigan, 48109-5314, United States

  • Regeneron study Site

    Providence, Rhode Island, 02908, United States

  • Regeneron study Site

    Charlottesville, Virginia, 22903, United States

  • Regeneron study Site

    Afula, 1834111, Israel

  • Regeneron study Site

    Petah Tikva, 49100, Israel

  • Regeneron study Site

    Tel Aviv, 6423906, Israel

  • Regeneron study Site

    Madrid, 28046, Spain

  • Regeneron study Site

    Pamplona, 31008, Spain

  • Regeneron study Site

    Taipei, Zhongzheng District, 10002, Taiwan

  • Regeneron study Site

    Taoyuan City, 33305, Taiwan

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