Nutritional deficiency disease

This study tests whether a pneumococcal vaccine (Pneumosil) can produce a strong immune response in children aged 6-59 months who are hospitalised with severe acute malnutrition. Half the children will receive the pneumococcal vaccine, and the other half will receive a typhoid va…

This study tests whether eating goat liver three times a week can improve anemia in teenage girls in Nepal, compared to standard iron-folic acid pills. Researchers will also look at how gut bacteria affect iron absorption. Sixty girls aged 15-19 with anemia will be randomly assig…

This study will test whether taking oral iron supplements every other day works as well as taking them daily for pregnant women with iron deficiency anemia in their second trimester. About 184 women will be randomly assigned to one of two dosing schedules for four weeks. Research…

This trial compares two ways to treat iron deficiency anemia in children aged 1 to 5 years: oral iron syrup taken daily for weeks, or a single intravenous (IV) iron infusion. The goal is to see which approach raises hemoglobin levels faster and with fewer side effects. The study …

This study tests whether adding Vitamin C, Omega-3 fatty acids, lignin, and lactulose to standard care can improve recovery in 108 adults after coronary artery bypass grafting (CABG). Participants will take the supplements daily for 10 weeks starting 15 days after surgery. The go…

This study tests whether a 12-day nutrition education program, called Positive Deviance/Hearth (PDH), can help children aged 6-59 months recover from moderate acute malnutrition. Caregivers learn to prepare nutrient-dense meals using local ingredients, with follow-up support. The…

This study tests a volunteer-led lifestyle program for older adults (60+) with sarcopenia, a condition causing muscle loss and weakness. The program includes workshops on nutrition and exercise, supported by nurses and trained volunteers. Researchers will measure changes in muscl…

This study tests whether a special omega-3-enriched nutritional drink can improve nutrition in people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The g…

This study tests whether high-calorie diets and special nutritional formulas can help underweight children aged 1 to 5 with congenital heart disease gain weight. Seventy-five children will be split into three groups: standard diet, high-calorie diet, or high-calorie diet plus a s…

This study tests a new, energy-rich therapeutic food for children aged 6 to 59 months with severe acute malnutrition. Researchers want to see if it helps kids recover physically and improves their brain development compared to the standard food. About 125 children in Pakistan wil…

This study tests a community-based nutrition program for 150 children aged 1-5 who are stunted or at risk. The program includes nutrition screening, education, supplements, and follow-up. The goal is to improve growth and reduce illness, not to cure malnutrition permanently.

This study tests an extended-release vitamin D capsule (CTAP101) in 40 children aged 8 to 17 with stage 3 or 4 chronic kidney disease, secondary hyperparathyroidism, and low vitamin D. Participants take one capsule daily at bedtime for 8 weeks. The goal is to see how the body pro…

This study tests whether sending doctors a reminder about IV iron guidelines helps heart failure patients with iron deficiency get the recommended treatment. About 3,000 hospitalized adults with heart failure and low iron will be included. Doctors in the intervention group receiv…

This study compares giving iron every other day versus daily to children with iron deficiency anemia. The goal is to see if the every-other-day schedule works just as well, causes fewer stomach problems, and is easier for families to follow. Sixty children aged 6 months to 12 yea…

This phase 3 trial in Bangladesh will test whether ferric citrate, a different form of iron, works better and causes fewer stomach problems than the standard ferrous fumarate for pregnant women with moderate to severe iron deficiency anemia. 680 women aged 18-35 in their second t…

This study looks at whether giving iron every day or every other day works better for children with iron deficiency anemia. About 100 kids aged 1-18 will take oral iron for 3 months. Researchers will check blood levels to see which schedule helps more and causes fewer stomach iss…

This study tests whether a structured exercise and nutrition plan can help older patients (70+) avoid losing the ability to care for themselves during a hospital stay. About 360 patients from a geriatric ward will take part. The goal is to see if personalized resistance and mobil…

This study compares a high-intensity loading dose of vitamin D2 to standard weekly dosing in 52 patients with newly diagnosed aggressive non-Hodgkin lymphoma who are also receiving standard chemotherapy. The goal is to see if the high-dose approach normalizes vitamin D levels fas…

This study looks at whether providing nutritional support to hospitalized patients who are at risk of malnutrition can lead to better health outcomes and be cost-effective. About 400 adults staying overnight in the hospital will take part. Researchers will track infections and to…

This study tests whether a daily supplement made from mealworm flour can improve the nutritional health of 40 children aged 2-10 with chronic malnutrition in the Democratic Republic of the Congo. One group will receive the mealworm supplement, while the other gets a traditional c…

This study compares an oral iron supplement (sucrosomial iron) to the usual intravenous (IV) iron given to anemic patients before heart surgery. About 75 adults with mild anemia scheduled for heart procedures will be randomly assigned to one of the two treatments. The goal is to …

This study looks at whether giving extra nutrition during dialysis sessions helps people on long-term hemodialysis build muscle and manage blood pressure. Researchers will compare the effects of this special nutrition with usual care in 16 adults who have been on dialysis for at …

This study looks at whether eating more protein can help people on dialysis avoid hospital stays. Dialysis removes nutrients like protein from the blood, and current guidelines are based on old research. The study will give some participants a high-protein diet or supplements and…

This study tests whether giving a single dose of intravenous iron the day after heart surgery can reduce the chance of long-term anemia. About 180 adults with low iron or anemia before surgery will be randomly assigned to receive either the iron treatment or a placebo. The main g…

This study tests whether combining a home exercise program with a daily anti-inflammatory nutritional supplement (Alisenoc™) can improve physical performance in frail, malnourished adults aged 75 and older. Participants will be randomly assigned to receive either the anti-inflamm…

This study tests whether a new oral iron supplement called Sucrosomial iron (Sideral Folico) can effectively treat iron deficiency anemia in pregnant women. Researchers will enroll 82 pregnant women between 24 and 32 weeks of pregnancy with mild to moderate anemia. The goal is to…

This phase III trial tests a vitamin B12 injection (hydroxocobalamin chloride) in 20 children aged 6 months to 18 years with a specific type of methylmalonic acidemia (cobalamin C deficiency). The goal is to see if the injection can normalize levels of certain acids in the blood …

This study tests whether giving vitamin K2 (MK-7) supplements to breastfed infants or their breastfeeding mothers can prevent vitamin K deficiency at 2 months of age. About 134 healthy, full-term babies who received standard vitamin K shots at birth will be enrolled. Some infants…

This study in Ethiopia tests whether a new 7-day package of a nutritional supplement (SQ-LNS) works as well as the usual daily packets for preventing malnutrition in children aged 6-24 months. Researchers will compare how well families stick to using each package type over 8 week…

This study tests whether giving magnesium before surgery can reduce emergence delirium—a state of confusion and agitation—in children aged 4 to 7 after adenotonsillectomy. Half the children receive magnesium by mouth before surgery, half receive it through an IV during surgery, a…

This study tests whether two dietary supplements, Congaplex and Immuplex, can improve age-related changes in fingernail ridges and hair health. Researchers will enroll 90 healthy adults aged 18 to 75 who have vertical nail ridges. Participants will take the supplements or an acti…

This study looks at whether Pilates or aerobic exercise can help new mothers improve their vitamin D and calcium levels, which often drop after childbirth. Sixty healthy women, 6-12 weeks after giving birth, will do either Pilates or aerobic exercise for 12 weeks. The goal is to …

This Phase 2 trial tests whether a drug called nanocrystalline megestrol acetate can help people with advanced liver cancer who are losing weight and appetite. About 88 patients will receive either the drug or a placebo for 12 weeks while also getting standard cancer therapy. The…

This study compares two types of iron supplements—standard ferrous salt and a newer liposomal form—in adult women with iron-deficiency anemia caused by heavy menstrual bleeding. About 100 women will take one of three treatments daily or every other day for three months. Researche…

This study tests whether silkworm pupa tablets can improve nutrition and reduce muscle loss (sarcopenia) in people who have completed cancer treatment. 480 participants will receive either the tablets or a placebo for 3 months. The main goal is to see if muscle strength and mass …

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests a 12-week program that provides medically tailored meals and coaching from a dietitian to children undergoing cancer treatment and their caregivers. The goal is to see if the program is practical and helpful for improving nutrition and reducing caregiver stress. …

This study looks at whether giving iron through an IV in the emergency department can help children with iron deficiency anemia recover faster than taking iron pills. Researchers will compare how quickly anemia resolves, how many children need blood transfusions or hospital stays…

This study investigates refeeding syndrome, a dangerous metabolic complication that can occur when severely malnourished patients start receiving nutrition again. Researchers will give a mixed-meal tolerance test to 15 adults who need a feeding tube after a month of very low food…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study looks at why some older adults lose their appetite while others keep a healthy one. Researchers will measure how taste, digestion, and hormones differ between the two groups. Twenty women aged 65-74 will take part. No treatment is given; the goal is simply to learn mor…

This study follows 120 malnourished adults undergoing major abdominal or pelvic cancer surgery to see how their gut function, nutrition, and risk of confusion (delirium) change in the first week after surgery. Researchers will also check if giving a natural chemical called seroto…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study tests whether giving breastfeeding mothers a daily iodine-containing multivitamin for 6 months helps their babies' brains and thyroid health. Researchers will compare babies' brain activity and development between moms who get the supplement and those who receive stand…

This pilot study in Guinea-Bissau will see if monthly growth checks by local health workers can reduce severe malnutrition in children aged 6 months to 5 years. About 400 children from two villages will take part. The study also compares three ways to measure arm size to find the…

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study tests whether vitamin D extracted from fish waste is as effective as synthetic vitamin D at raising blood levels in healthy adults with mild deficiency. 48 participants will take either fish-derived or synthetic vitamin D daily for 3 months. The goal is to see if a sus…

This study looks at whether three proteins in urine—RhoA, NGF, and BDNF—can help doctors diagnose and monitor overactive bladder in children aged 4 to 18 who also have low vitamin D. Researchers will measure these proteins before and after standard behavioral therapy (urotherapy)…

This study in Assiut, Egypt, will check 116 children aged 2-15 for intestinal parasites to see if these infections are more common in malnourished kids compared to healthy ones. The goal is to understand how parasites like Giardia and hookworms might cause or worsen malnutrition …

This study tests a 3D-printed camera attachment that helps dental students take consistent, high-quality photos of teeth. The goal is to see if it improves the accuracy of dental records and nutrition knowledge. Four hundred dental students in Egypt will use either the new tool o…

This study looks at how different types of anemia—like iron deficiency or thalassemia—can change HbA1c levels, a common test for diabetes, in people who do not have diabetes. Researchers will compare HbA1c results between 100 non-diabetic adults with various anemias and a healthy…

This study aims to see if two short questionnaires can accurately measure how much dietary fiber and iron people eat, compared to the standard method of keeping detailed food records for five days. About 50 adults aged 18 to 65 will fill out the questionnaires and also complete 2…

This study tests whether giving less therapeutic food and requiring fewer clinic visits can still effectively treat severe acute malnutrition in children aged 6-59 months in Kenya. About 2,274 children will take part across 45 health facilities. The goal is to find a treatment ap…

This study aims to create a nutrition algorithm called NACHO that suggests foods and recipes tailored to cancer patients' needs. Researchers will work with dietitians, clinicians, and patient advisors to develop the tool, then test it with 130 patients who are undergoing or have …

This study looks at 300 adults hospitalized with heart failure to see if iron deficiency (with or without anemia) is linked to abnormal heart rhythms or ECG changes. Researchers will measure iron levels and monitor for arrhythmias like atrial fibrillation or ventricular tachycard…

This study will check the health, nutrition, and daily living abilities of 330 older adults (age 60+) living in a rural village in Assiut, Egypt. Researchers will interview participants and take simple physical measurements like weight and blood pressure. No treatments are given—…

This study looks at whether older adults (70+) with low muscle mass are more likely to have serious bleeding while taking common blood thinners (apixaban or rivaroxaban). Researchers will compare muscle mass in 110 patients who had a bleeding event with those who did not. The goa…

This study will check how common vitamin B12 deficiency is in preterm infants (born before 37 weeks) at the time they go home from the hospital. Researchers will measure B12 and related markers in blood samples from 40 babies. The goal is to understand if these vulnerable infants…