Nutritional deficiency disease

This study looks at whether giving a higher dose of vitamin D (800 IU daily) to extremely premature infants (born before 28 weeks or weighing under 1000 grams) can improve their health. Researchers will check vitamin D levels and measure effects on the lungs, bones, immune system…

This study looks at whether giving extra vitamin D (800 IU daily) to extremely premature infants (born before 28 weeks or weighing under 1000 grams) improves their lung, bone, immune, and brain health. About 180 babies will receive either the extra vitamin D or usual care for the…

This study tests whether adding creatine and HMB supplements to a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older are taking part, receiving …

This study tests whether giving pregnant women a daily vitamin B12 supplement (50 micrograms) from early pregnancy until six months after birth helps their children grow and think better. Researchers are enrolling 800 pregnant women in Nepal who are at risk of low B12 levels. The…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study tests whether giving severely malnourished children lower-calorie feeds during the first stage of hospital treatment is safe and helps them survive. About 135 children aged 6 months to 5 years will receive either a standard feed or one of two reduced-calorie feeds. Res…

This study tests whether a pharmacist-led education program can help women with hypothyroidism and low vitamin D levels improve their vitamin D levels and medication habits. Sixty women will be split into two groups: one receives standard care, the other gets counseling, brochure…

This study tests four new ready-to-drink nutritional supplements in 100 adults who are malnourished or at risk. Participants take one of the supplements daily for 28 days alongside their usual diet. Researchers track how well people stick with the drink, their nutrient intake, an…

This study tests whether adding a nutrition education program for caregivers to standard oral iron therapy improves hemoglobin levels in children aged 1-5 with iron deficiency anemia. 150 children will be split into two groups: one gets iron pills alone, the other gets iron pills…

This Phase II trial tests whether high-dose vitamin D (4,000 IU daily) can correct deficiency and slow cognitive decline better than standard doses in 180 older adults aged 65-90. Participants include those with normal thinking, mild impairment, or early Alzheimer's. The study la…

This study is testing a liposomal iron supplement with vitamin C and fiber (LISEFEX®) in 74 Mexican adults with mild to moderate iron deficiency anemia. Researchers are observing how well the supplement raises hemoglobin levels and how acceptable it is to patients. The supplement…

Severe acute malnutrition affects millions of children worldwide and often leads to death after hospital discharge. This phase 3 trial tests whether giving a combination of antibiotics (rifampicin, azithromycin, isoniazid, and vitamin B6) for several weeks can lower the risk of d…

This study tests whether adding a daily nutrient supplement (SQ-LNS) to monthly malaria prevention visits can reduce both malaria and malnutrition in children aged 6-24 months in Burkina Faso. Researchers will compare malaria rates and nutritional status between children receivin…

This study tests a new oral nutritional supplement called AYMES SWIFT in 40 adults who are malnourished or at risk of malnutrition. Participants will take the supplement for 7 days, and researchers will measure how well they tolerate it (digestive comfort) and how much they like …

This study tests whether a special food supplement with added omega-3s and choline can help undernourished pregnant women carry their babies longer and improve their babies' brain development. It also tests a simple talk therapy program to reduce depression during and after pregn…

This study tests whether adding Moringa leaf powder to standard iron pills can better improve hemoglobin levels in pregnant women with iron deficiency anemia. About 59 women in their third trimester will take either Moringa capsules plus iron or iron alone for 60 days. Researcher…

This study looks at whether providing daily nutritional supplements (like instant milk or soy drinks) can improve the health of malnourished older adults who live alone. Thirty participants will receive these supplements for 12 months while researchers track changes in their nutr…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study aims to help moderately malnourished children aged 7-23 months in Punjab, Pakistan grow healthy by teaching mothers better feeding, hygiene, and care practices. About 350 mother-child pairs will take part in a program where women support each other using local solution…

This study looks at whether a personalized exercise and nutrition plan can prevent older adults (70+) from losing strength and independence during a hospital stay. About 25 patients in a geriatric ward will try supervised resistance exercises, with some also getting a tailored di…

This pilot study tests whether providing weekly food deliveries and bi-weekly nutrition counseling to mothers can improve growth in malnourished children aged 6-12 months in Lusaka, Zambia. The goal is to see if better basic nutrition can reduce stunting, which affects over half …

This study compares two different doses of vitamin D supplements in 108 adults with type 2 diabetes who also have low vitamin D levels. Researchers will measure changes in blood sugar and HbA1c over time to see if higher doses improve diabetes control. Participants must be aged 4…

This study tests whether adding choline (a nutrient found in eggs and meat) to a standard food supplement helps children with moderate acute malnutrition avoid becoming severely malnourished. About 1,500 children aged 6 to 59 months in Malawi will receive either the standard supp…

This study was designed to test the safety of an iron pill called ferric citrate in children aged 6 to 17 with iron deficiency anemia and chronic kidney disease (not on dialysis). The plan was to compare the iron pill to standard care over 24 weeks. However, the study was withdra…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This study looks at whether a special drink made with easily digested protein and MCT oil can help improve malnutrition in cancer patients who are having radiotherapy. The study will follow 132 adults with head and neck, lung, rectal, or esophageal cancer for 12 weeks. Researcher…

This study tests whether giving a single high-dose vitamin D pill to patients with low vitamin D levels before hip or knee replacement surgery can reduce complications like infection. About 200 adults with osteoarthritis and vitamin D deficiency will receive 300,000 IU of vitamin…

This study tests whether vitamin D3 supplements can improve asthma control in adolescents aged 12-17 who have obesity, non-allergic asthma, and vitamin D deficiency. Participants receive either a high or standard daily dose of vitamin D3 for three months. Researchers will measure…

This study tests whether improved nutritional support, delivered through digital tools and personalized advice, can reduce malnutrition in cancer patients. Around 130 adults with gynecologic, colorectal, or lymphoma cancers will receive either standard dietary advice or enhanced …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests whether a newer form of iron (liposomal iron) works better than standard iron drops to prevent iron deficiency anemia in premature babies. About 60 preterm infants born at or before 34 weeks will receive either daily standard iron, daily liposomal iron, or liposo…

This study tests whether pregnant women who eat two eggs daily have babies with longer birth lengths and better development. Researchers in Rwanda are giving eggs to some women and comparing them to those eating their usual diet. The goal is to see if this simple, affordable food…

This study tests whether phentolamine eye drops can improve vision in low light for people who had laser eye surgery and now see glare, halos, or starbursts at night. About 200 adults will use the drops or a placebo every evening for two weeks. The main goal is to see if more peo…

This study looks at whether taking vitamin D can reduce nerve pain caused by chemotherapy in people with low vitamin D levels. About 120 cancer patients will be split into two groups: one gets vitamin D supplements, the other gets standard care. The goal is to see if vitamin D he…

This study tests whether taking vitamin D3 before a root canal can reduce pain afterward. Fifty-four adults with low vitamin D and painful tooth inflammation will receive either a single high dose, a three-day course, or a placebo. Pain levels and painkiller use will be tracked f…

This study looks at whether giving vitamin D supplements to women with depression and low vitamin D levels can change their brain waves. Researchers will measure brain activity using a non-invasive EEG scan before and after supplementation. The trial includes 34 women aged 20-40 …

This study looks at how well children aged 1 to 16 tolerate and accept new nutritional feeds made from real food ingredients. The feeds are given through a tube or as a drink. Researchers will track stomach issues like pain, bloating, and nausea over 28 days. The goal is to see i…

This study tests a new ready-to-use nutritional supplement drink designed for people with dysphagia (swallowing problems). Over 28 days, 40 adults who need at least 250 calories per day from a milkshake-style supplement will take the drink daily. Researchers will check how well p…

This study looks at how well a new iron supplement made from fish (SalmoFer®) is absorbed by the body and whether it causes stomach discomfort. About 61 women aged 21 to 42 with low iron or mild anemia will take the supplement and have their iron levels checked through blood test…

This study looks at whether vitamin C can increase body heat produced by the nervous system and boost vitamin D levels in the blood. Researchers will measure temperature and blood samples in 20 overweight adults aged 18-40 during a stimulation test. The goal is to understand how …

This pilot study tests a step-by-step nutrition care plan called P-INPAC for children in the hospital. The goal is to see if training staff and using simple screening tools can help catch and manage malnutrition early. About 600 children across three hospitals will be involved, a…

This study observes 69 adults with chronic kidney disease who are on hemodialysis. Researchers want to find the best way to diagnose malnutrition using the GLIM criteria and other tools. The goal is to see which methods best predict declines in quality of life, muscle strength, a…

This study looks at whether it is practical to offer a blood test for DHA (a nutrient important for baby's brain development) to all pregnant women early in their care. About 650 patients starting prenatal care at participating clinics will be invited to take the test. The main g…

This study looks at whether storing blood samples (frozen or at different temperatures) changes the accuracy of a vitamin D test called the ALPCO 25(OH) Vitamin D CLIA Kit. Researchers will compare results from fresh blood with those from stored samples in 80 healthy adults. The …

This study aimed to find the right daily dose of vitamin C for older people living in care homes, who often have low levels of this immune-supporting nutrient. The goal was to gather data for a future trial on whether vitamin C could help reduce the risk and severity of respirato…

This study aimed to see if a 6-month nutrition plan could improve weight and strength in malnourished older adults compared to standard hospital care. It was designed for people aged 65 and older in Italian hospitals. However, the study was withdrawn before enrolling any particip…

This study looks at how the bacteria in a pregnant woman's gut (her microbiome) and her nutrition affect her baby's growth and health. Researchers are following 800 young pregnant women (28 and under) in Toronto throughout pregnancy and for a year after birth. They collect stool,…

This pilot study looks at why military personnel often have low iron levels during training. Six physically active adults will receive either erythropoietin or a placebo and then do a 90-minute loaded march. The goal is to find the best way to measure iron absorption after exerci…

This study tests a virtual training program called CHOICE+ for staff in long-term care homes. The goal is to improve the mealtime experience for elderly residents, helping them eat better and stay healthier. About 800 residents, staff, and family members from 13-18 homes will tak…

This study was designed to see if giving pregnant women nutrition advice based on their unique biology, lifestyle, and health could improve their health and their baby's health. It planned to enroll women less than 20 weeks pregnant, excluding those with high-risk conditions. How…

This observational study measures how common malnutrition is in people with relapsing-remitting multiple sclerosis (RRMS) and whether it is linked to disability. Researchers will assess nutritional status, body composition, and other factors like depression and incontinence in 16…

This study looks at how to improve a parenting program for malnourished children aged 6-24 months in Bangladesh. Researchers are testing two approaches: one using program-supplied toys and another where mothers make toys. The goal is to see if these strategies improve children's …

This study tests three different daily doses of vitamin B12 (2.6, 10, and 50 micrograms) in 40 pregnant women and 10 non-pregnant women in Tanzania. The goal is to see how the body processes B12 during pregnancy and find the optimal dose for future larger trials. Participants tak…

This study looks at whether a new vitamin B12 supplement, natural orange extract, or a mix of both can boost physical and mental performance. It involves 20 healthy, well-trained men aged 18-45 who regularly eat citrus fruits. Participants will do intense bike tests and reaction-…

This study follows 70 healthy infants from rural Pakistan over their first two years of life. Researchers will regularly test the babies' gut bacteria to see how it changes and whether it relates to their growth and nutrition. The goal is to understand why some children become ma…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to study immune cells called monocytes and see if they trigger a hormone that raises blood pressure. The goal i…

This study tests whether providing technology training and digital nutrition education can improve diet quality, physical activity, and reduce social isolation among older adults who attend meal programs. About 369 participants aged 60 and older who lack tech access or skills wil…

This study looks at vitamin A levels in 90 adults with vocal fold leukoplakia, a condition that causes white patches on the vocal cords. Researchers want to see if vitamin A status differs between people with and without precancerous changes. Participants provide blood and tissue…

This pilot study looks at how well young children absorb iron from special nutrient supplements. Researchers will give 30 children in Kenya (ages 1-3) a supplement with a harmless iron tracer, then measure iron levels in their blood two weeks later. Half the children are healthy,…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study aimed to see if iron deficiency in new mothers is linked to depression and poorer interactions with their babies. Researchers planned to compare iron-deficient and iron-sufficient mothers using video-recorded play sessions. However, the study was withdrawn before any p…

This study looks at whether low vitamin D in pregnant women affects the baby's brain development. Researchers will use ultrasound to compare brain images of 100 women with and without vitamin D deficiency. The goal is to understand possible effects during the second and third tri…

This study looks at how a program that helps families lift themselves out of poverty affects the growth and learning of children aged 0-9 in Uganda. Researchers will compare kids in families that received the program to those that did not, measuring things like height, anemia, th…

This study looks at whether giving extra amino acids to critically ill patients on breathing machines helps their bodies build more protein. Researchers will measure protein balance using special tracers. The goal is to understand how nutrition affects recovery in the ICU. About …

This study looks at whether vitamin D levels in the blood affect bone loss around dental implants that support lower dentures. Researchers will measure bone changes and gum health in 40 adults aged 40-60 who already have these implants. The goal is to understand if vitamin D help…

This study follows 1,304 healthy Indian adolescents aged 8–10 over time to see how their growth, bone health, and muscle development are linked to their parents' nutrition. Researchers aim to understand why malnutrition persists across generations and identify windows of opportun…