Fighting cancer wasting: can diet and exercise make olanzapine work better?
NCT ID NCT07722806
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial tests whether adding a structured nutrition and exercise program to the standard appetite-stimulating drug olanzapine can improve quality of life in people with advanced solid tumors who have poor appetite. Participants are randomly assigned to receive olanzapine alone or olanzapine plus personalized dietary advice, exercise sessions, and a protein supplement. The study tracks quality of life, fatigue, and nutritional status over 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- olanzapine plus a standardized nutrition and exercise program
- What this could lead to
- If it works, this could point toward a better way to manage appetite loss and malnutrition in advanced cancer, potentially improving quality of life.
- What could go wrong
- This is a mid-stage trial with 130 participants, so results may not apply to all cancer patients. The added program requires time and effort, and olanzapine can cause side effects like drowsiness or weight gain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kantonsspital Winterthur
Winterthur, 8401, Switzerland
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