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Metabolic disease
MONDO:0005066A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.
Also known as: disorder of metabolic process, metabolic disease, metabolic disorder, metabolic process disease, disease of metabolism
7369 clinical trials for this condition and its sub-types, 246 tagged with Metabolic disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Metabolic disease
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Glucose metabolism disease 62 trials · 4,139 incl. sub-types
9 sub-types
- Diabetes mellitus 1,275 trials · 3,825 incl. sub-types Sub-types →
- Prediabetes syndrome 445 trials
- Glucose intolerance 149 trials
- Hyperglycemia 132 trials
- Hypoglycemia 119 trials
- Hyperinsulinism 34 trials · 42 incl. sub-types Sub-types →
- Disorder of gluconeogenesis 0 trials · 1 incl. sub-types Sub-types →
- Glyceraldehyde-3-phosphate dehydrogenase deficiency 0 trials
- Triosephosphate isomerase deficiency 0 trials
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Inborn errors of metabolism 48 trials · 2,231 incl. sub-types
93 sub-types
- Inherited lipid metabolism disorder 201 trials · 644 incl. sub-types Sub-types →
- Inborn carbohydrate metabolic disorder 3 trials · 370 incl. sub-types Sub-types →
- Abdominal obesity-metabolic syndrome 302 trials · 359 incl. sub-types Sub-types →
- Lysosomal storage disease 38 trials · 303 incl. sub-types Sub-types →
- Inborn disorder of energy metabolism 2 trials · 235 incl. sub-types Sub-types →
- Inborn disorder of amino acid and other organic acid metabolism 0 trials · 225 incl. sub-types Sub-types →
- Waldenstrom macroglobulinemia 136 trials Sub-types →
- DNA repair disease 13 trials · 105 incl. sub-types Sub-types →
- Hereditary amyloidosis 19 trials · 79 incl. sub-types Sub-types →
- Inborn disorder of porphyrin metabolism 0 trials · 63 incl. sub-types Sub-types →
- Mucopolysaccharidosis or mucopolysaccharidosis-like disorder 0 trials · 62 incl. sub-types Sub-types →
- Inborn metal metabolism disorder 1 trial · 60 incl. sub-types Sub-types →
- Disorder of metabolite absorption and transport 0 trials · 59 incl. sub-types Sub-types →
- Inborn disorder of purine or pyrimidine metabolism 1 trial · 50 incl. sub-types Sub-types →
- Plasma protein metabolism disease 0 trials · 47 incl. sub-types Sub-types →
- Peroxisomal disease 2 trials · 38 incl. sub-types Sub-types →
- Congenital disorder of glycosylation 7 trials · 36 incl. sub-types Sub-types →
- Monogenic diabetes 9 trials · 24 incl. sub-types Sub-types →
- Glycoprotein metabolism disease 1 trial · 23 incl. sub-types Sub-types →
- Disorder of lysosomal-related organelles 0 trials · 17 incl. sub-types Sub-types →
- Familial intrahepatic cholestasis 1 trial · 17 incl. sub-types Sub-types →
- Hereditary lipodystrophy 2 trials · 17 incl. sub-types Sub-types →
- Hypophosphatasia 13 trials Sub-types →
- Familial hypoparathyroidism 0 trials · 10 incl. sub-types Sub-types →
- Inborn disorder of biogenic amine metabolism and transport 0 trials · 10 incl. sub-types Sub-types →
- Inherited thyroid metabolism disease 0 trials · 8 incl. sub-types Sub-types →
- Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types Sub-types →
- Inborn vitamin metabolic disorder 0 trials · 7 incl. sub-types Sub-types →
- Inborn aminoacylase deficiency 0 trials · 6 incl. sub-types Sub-types →
- Disorder of peptide and amine metabolism 0 trials · 4 incl. sub-types Sub-types →
- Congenital disorder of deglycosylation 0 trials · 2 incl. sub-types Sub-types →
- Diastrophic dysplasia 2 trials
- Hypercalcemia, infantile 2 trials Sub-types →
- Hypoalphalipoproteinemia, primary, 1 2 trials
- 2-hydroxyglutaric aciduria 0 trials · 1 incl. sub-types Sub-types →
- Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome 1 trial
- Diabetes mellitus, noninsulin-dependent, 1 1 trial
- Diabetes mellitus, noninsulin-dependent, 2 1 trial
- Familial hypocalciuric hypercalcemia 0 trials · 1 incl. sub-types Sub-types →
- Fish eye disease 1 trial
- Hereditary recurrent myoglobinuria 0 trials · 1 incl. sub-types Sub-types →
- Thiopurine metabolic disease 0 trials · 1 incl. sub-types Sub-types →
- 4-hydroxyphenylacetic aciduria 0 trials
- 5-nucleotidase syndrome 0 trials
- APO A-i deficiency 0 trials
- CFTR-related metabolic syndrome/CF screen positive, inconclusive diagnosis 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type 0 trials Sub-types →
- Lane Hamilton syndrome 0 trials
- NAD(P)HX dehydratase deficiency 0 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
- Achondrogenesis type IB 0 trials
- Antigen-peptide-transporter 2 deficiency 0 trials
- Apolipoprotein c-III deficiency 0 trials
- Aromatase excess syndrome 0 trials
- Atelosteogenesis type II 0 trials
- Autosomal dominant dopa-responsive dystonia 0 trials Sub-types →
- Autosomal dominant myoglobinuria 0 trials
- Autosomal dominant proximal renal tubular acidosis 0 trials
- Autosomal recessive proximal renal tubular acidosis 0 trials
- Cardiomyopathy hypogonadism metabolic anomalies 0 trials
- Chondrocalcinosis 2 0 trials
- Chondrodysplasia with joint dislocations, gPAPP type 0 trials
- Combined ApoA-I and ApoC-III deficiency 0 trials
- Defective apolipoprotein b-100 0 trials
- Deficiency of coenzyme q cytochrome c reductase 0 trials
- Diabetes mellitus, noninsulin-dependent, 3 0 trials
- Diabetes mellitus, noninsulin-dependent, 4 0 trials
- Diabetes mellitus, noninsulin-dependent, 5 0 trials
- Familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome 0 trials
- Ferro-cerebro-cutaneous syndrome 0 trials
- Gluthathione peroxidase deficiency 0 trials
- Hemolytic anemia due to diphosphoglycerate mutase deficiency 0 trials
- Hypercholesterolemia, familial, 4 0 trials
- Hypermanganesemia with dystonia 0 trials Sub-types →
- Hypertriglyceridemia 1 0 trials
- Hypertriglyceridemia 2 0 trials
- Hypoalphalipoproteinemia, primary, 2 0 trials Sub-types →
- Hypotonia-failure to thrive-microcephaly syndrome 0 trials
- Inborn disorder of aspartate family metabolism 0 trials Sub-types →
- Inborn glycerol kinase deficiency 0 trials Sub-types →
- Inherited threoninemia 0 trials
- Multiple epiphyseal dysplasia type 4 0 trials
- Normophosphatemic familial tumoral calcinosis 0 trials
- Renal tubular acidosis, distal, 3, with or without sensorineural hearing loss 0 trials
- Spondyloepimetaphyseal dysplasia, PAPSS2 type 0 trials
- Spondyloepiphyseal dysplasia with congenital joint dislocations 0 trials
- Striatonigral degeneration 0 trials Sub-types →
- Sulfide quinone oxidoreductase deficiency 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 1 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 2 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 3 0 trials
- Uridine-cytidineuria 0 trials
- Weinstein kliman scully syndrome 0 trials
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Proteostasis deficiencies 1 trial · 561 incl. sub-types
4 sub-types
- Amyloidosis 133 trials · 323 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- TDP-43 proteinopathy 3 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
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Hyperlipidemia 307 trials · 401 incl. sub-types
3 sub-types
- Familial hyperlipidemia 8 trials · 130 incl. sub-types Sub-types →
- Hyperalphalipoproteinemia 0 trials Sub-types →
- Laminopathy type Decaudain-Vigouroux 0 trials
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Carbohydrate metabolism disease 4 trials · 385 incl. sub-types
6 sub-types
- Inborn carbohydrate metabolic disorder 3 trials · 370 incl. sub-types Sub-types →
- Carbohydrate transport disease 0 trials · 156 incl. sub-types Sub-types →
- Scurvy 13 trials
- Intestinal disaccharidase deficiency 0 trials · 2 incl. sub-types Sub-types →
- Acquired carbohydrate metabolism disease 0 trials
- Glycerol metabolism disease 0 trials
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Developmental anomaly of metabolic origin 0 trials · 384 incl. sub-types
57 sub-types
- Inborn mitochondrial metabolism disorder 59 trials · 127 incl. sub-types Sub-types →
- Fabry disease 64 trials
- Mucopolysaccharidosis 14 trials · 62 incl. sub-types Sub-types →
- Sterol biosynthesis disorder 0 trials · 45 incl. sub-types Sub-types →
- Fanconi anemia 29 trials · 42 incl. sub-types Sub-types →
- Hypophosphatasia 13 trials Sub-types →
- Oligosaccharidosis 0 trials · 11 incl. sub-types Sub-types →
- Pseudohypoparathyroidism 8 trials · 9 incl. sub-types Sub-types →
- Zellweger spectrum disorders 6 trials · 7 incl. sub-types Sub-types →
- Cockayne syndrome 6 trials Sub-types →
- Creatine transporter deficiency 6 trials
- Mucolipidosis 4 trials · 5 incl. sub-types Sub-types →
- Classic homocystinuria 4 trials
- Mucosulfatidosis 4 trials
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 2 trials
- AICA-ribosiduria 1 trial
- Nijmegen breakage syndrome 1 trial
- SLC35A2-congenital disorder of glycosylation 1 trial
- Arthrogryposis-renal dysfunction-cholestasis syndrome 1 trial Sub-types →
- Encephalopathy due to sulfite oxidase deficiency 0 trials · 1 incl. sub-types Sub-types →
- Occipital horn syndrome 1 trial
- ALDH18A1-related de Barsy syndrome 0 trials
- Al-Gazali syndrome 0 trials
- B4GALT1-congenital disorder of glycosylation 0 trials
- CADDS 0 trials
- CHIME syndrome 0 trials
- COG1-congenital disorder of glycosylation 0 trials
- COG7-congenital disorder of glycosylation 0 trials
- Ehlers-Danlos syndrome, musculocontractural type 0 trials Sub-types →
- Ehlers-Danlos syndrome, spondylodysplastic type 0 trials Sub-types →
- Larsen-like syndrome, B3GAT3 type 0 trials
- MGAT2-congenital disorder of glycosylation 0 trials
- Neu-Laxova syndrome 0 trials Sub-types →
- Nijmegen breakage syndrome-like disorder 0 trials
- Peters plus syndrome 0 trials
- RFT1-congenital disorder of glycosylation 0 trials
- SHORT syndrome 0 trials
- SLC39A8-CDG 0 trials
- SSR4-congenital disorder of glycosylation 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- XYLT1-congenital disorder of glycosylation 0 trials
- Autism spectrum disorder - epilepsy - arthrogryposis syndrome 0 trials
- Autosomal recessive cutis laxa type 2 0 trials Sub-types →
- Cutis laxa, autosomal dominant 3 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 15 0 trials
- Hyperphosphatasia-intellectual disability syndrome 0 trials Sub-types →
- Mandibuloacral dysplasia 0 trials Sub-types →
- Mucopolysaccharidosis-plus syndrome 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 1 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 3 0 trials
- Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome 0 trials
- Pontocerebellar hypoplasia type 1 0 trials Sub-types →
- Progressive hypotonia-intellectual disability-facial dysmorphism syndrome due to FYVE-defective RBSN 0 trials
- Temtamy preaxial brachydactyly syndrome 0 trials
- Transketolase deficiency 0 trials
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Diabetic retinopathy 148 trials · 260 incl. sub-types
3 sub-types
- Diabetic macular edema 120 trials
- Background diabetic retinopathy 26 trials Sub-types →
- Proliferative diabetic retinopathy 19 trials
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Acquired metabolic disease 0 trials · 183 incl. sub-types
13 sub-types
- AL amyloidosis 93 trials · 99 incl. sub-types Sub-types →
- Paroxysmal nocturnal hemoglobinuria 73 trials Sub-types →
- Acquired lipodystrophy 3 trials · 9 incl. sub-types Sub-types →
- Acquired hyperprolactinemia 1 trial Sub-types →
- Auto-brewery syndrome 1 trial
- Acquired adrenogenital syndrome 0 trials
- Acquired carbohydrate metabolism disease 0 trials
- Acquired lactic acidosis 0 trials
- Acquired mineral metabolism disease 0 trials
- Acquired porphyria 0 trials Sub-types →
- Acquired xanthinuria 0 trials
- Bladder fermentation syndrome 0 trials
- Carotenemia 0 trials
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Amino acid metabolism disease 2 trials · 160 incl. sub-types
4 sub-types
- Inborn disorder of amino acid metabolism 6 trials · 159 incl. sub-types Sub-types →
- Creatine biosynthetic process disease 0 trials · 1 incl. sub-types Sub-types →
- Glycine metabolism disease 0 trials Sub-types →
- Valine metabolism disease 0 trials Sub-types →
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Disorder of organic acid metabolism 0 trials · 154 incl. sub-types
20 sub-types
- Disorder of phenylalanine metabolism 0 trials · 60 incl. sub-types Sub-types →
- Pyruvate metabolism disorder 0 trials · 31 incl. sub-types Sub-types →
- Disorder of fatty acid oxidation and ketogenesis 1 trial · 16 incl. sub-types Sub-types →
- Scurvy 13 trials
- Inborn disorder of bile acid synthesis 2 trials · 12 incl. sub-types Sub-types →
- Inborn disorder of methionine cycle and sulfur amino acid metabolism 0 trials · 11 incl. sub-types Sub-types →
- Disorder of tyrosine metabolism 0 trials · 8 incl. sub-types Sub-types →
- Cerebral creatine deficiency syndrome 0 trials · 6 incl. sub-types Sub-types →
- Inborn disorder of branched-chain amino acid metabolism 0 trials · 4 incl. sub-types Sub-types →
- Inborn disorder of ornithine metabolism 0 trials · 4 incl. sub-types Sub-types →
- Biotin metabolic disease 0 trials · 3 incl. sub-types Sub-types →
- Creatine biosynthetic process disease 0 trials · 1 incl. sub-types Sub-types →
- Gamma-amino butyric acid metabolism disorder 0 trials · 1 incl. sub-types Sub-types →
- Inborn serine deficiency 0 trials · 1 incl. sub-types Sub-types →
- Inherited lipoic acid biosynthesis defect 0 trials · 1 incl. sub-types Sub-types →
- Glycine metabolism disease 0 trials Sub-types →
- Inborn disorder of histidine metabolism 0 trials Sub-types →
- Inborn disorder of proline metabolism 0 trials Sub-types →
- Inborn disorder of tryptophan metabolism 0 trials Sub-types →
- Valine metabolism disease 0 trials Sub-types →
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Mineral metabolism disease 2 trials · 137 incl. sub-types
13 sub-types
- Calcium metabolic disease 5 trials · 62 incl. sub-types Sub-types →
- Phosphorus metabolism disease 1 trial · 33 incl. sub-types Sub-types →
- Iron metabolism disease 2 trials · 22 incl. sub-types Sub-types →
- Sulfur metabolism disease 0 trials · 14 incl. sub-types Sub-types →
- Potassium deficiency disease 4 trials · 5 incl. sub-types Sub-types →
- Diastrophic dysplasia 2 trials
- Achondrogenesis type IB 0 trials
- Acquired mineral metabolism disease 0 trials
- Atelosteogenesis type II 0 trials
- Chondrodysplasia with joint dislocations, gPAPP type 0 trials
- Multiple epiphyseal dysplasia type 4 0 trials
- Spondyloepimetaphyseal dysplasia, PAPSS2 type 0 trials
- Spondyloepiphyseal dysplasia with congenital joint dislocations 0 trials
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Diabetic kidney disease 133 trials
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Hyperlipoproteinemia 8 trials · 106 incl. sub-types
4 sub-types
- Familial hypercholesterolemia 58 trials · 94 incl. sub-types Sub-types →
- Familial lipoprotein lipase deficiency 6 trials
- Hyperalphalipoproteinemia 0 trials Sub-types →
- Hypercholesterolemia, familial, 4 0 trials
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Steroid metabolism disease 1 trial · 104 incl. sub-types
4 sub-types
- Sterol metabolism disorder 0 trials · 60 incl. sub-types Sub-types →
- Adrenogenital syndrome 0 trials · 41 incl. sub-types Sub-types →
- Vitamin D hydroxylation-deficient rickets, type 1B 3 trials
- Corticosterone methyloxidase type 1 deficiency 0 trials
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Gout 103 trials
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Hypertriglyceridemia 75 trials
2 sub-types
- Hypertriglyceridemia 1 0 trials
- Hypertriglyceridemia 2 0 trials
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Disorder of GPI anchor biosynthesis 0 trials · 73 incl. sub-types
11 sub-types
- Paroxysmal nocturnal hemoglobinuria 73 trials Sub-types →
- Developmental and epileptic encephalopathy, 55 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental and epileptic encephalopathy, 80 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 15 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 16 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 17 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 18 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 25 0 trials
- Inborn disorder of glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation 0 trials Sub-types →
- Neurodevelopmental disorder with hypotonia and cerebellar atrophy, with or without seizures 0 trials
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Porphyrin metabolism disease 0 trials · 64 incl. sub-types
2 sub-types
- Inborn disorder of porphyrin metabolism 0 trials · 63 incl. sub-types Sub-types →
- Porphyria 8 trials · 25 incl. sub-types Sub-types →
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Lipodystrophy 30 trials · 48 incl. sub-types
5 sub-types
- Partial lipodystrophy 7 trials · 19 incl. sub-types Sub-types →
- Hereditary lipodystrophy 2 trials · 17 incl. sub-types Sub-types →
- Generalized lipodystrophy 8 trials · 11 incl. sub-types Sub-types →
- Acquired lipodystrophy 3 trials · 9 incl. sub-types Sub-types →
- Localized lipodystrophy 0 trials · 4 incl. sub-types Sub-types →
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Bilirubin metabolism disease 0 trials · 48 incl. sub-types
2 sub-types
- Inborn disorder of bilirubin metabolism 0 trials · 39 incl. sub-types Sub-types →
- Hyperbilirubinemia 28 trials Sub-types →
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Disorder of acid-base balance 6 trials · 28 incl. sub-types
1 sub-type
- Acidosis disorder 4 trials · 23 incl. sub-types Sub-types →
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Vitamin B12 deficiency 12 trials · 15 incl. sub-types
1 sub-type
- Inborn disorder of cobalamin metabolism and transport 1 trial · 3 incl. sub-types Sub-types →
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Purine metabolism disease 0 trials · 14 incl. sub-types
1 sub-type
- Inborn disorder of purine metabolism 0 trials · 14 incl. sub-types Sub-types →
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Pyrimidine metabolism disease 0 trials · 11 incl. sub-types
1 sub-type
- Inborn disorder of pyrimidine metabolism 0 trials · 11 incl. sub-types Sub-types →
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Lactic acidosis 8 trials
3 sub-types
- Acquired lactic acidosis 0 trials
- Cardiomyopathy-hypotonia-lactic acidosis syndrome 0 trials
- Mitochondrial DNA depletion syndrome 9 0 trials
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Chondrocalcinosis 5 trials · 7 incl. sub-types
3 sub-types
- Chondrocalcinosis due to apatite crystal deposition 2 trials
- Chondrocalcinosis 1 0 trials
- Chondrocalcinosis 2 0 trials
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Hypoalphalipoproteinemia 1 trial · 7 incl. sub-types
6 sub-types
- LCAT deficiency 1 trial · 4 incl. sub-types Sub-types →
- Apolipoprotein A-I deficiency 0 trials · 2 incl. sub-types Sub-types →
- Tangier disease 0 trials
- Apolipoprotein A-II deficiency 0 trials
- Combined ApoA-I and ApoC-III deficiency 0 trials
- Familial apolipoprotein gene cluster deletion syndrome 0 trials
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Glutaric aciduria 0 trials · 5 incl. sub-types
3 sub-types
- Glutaryl-CoA dehydrogenase deficiency 4 trials
- Multiple acyl-CoA dehydrogenase deficiency 1 trial Sub-types →
- Glutaric acidemia type 3 0 trials
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Tumor lysis syndrome 3 trials
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Dopa-responsive dystonia 1 trial · 2 incl. sub-types
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Ochronosis disorder 1 trial
1 sub-type
- Exogenous ochronosis 0 trials
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Xanthoma 1 trial
1 sub-type
- Verruciform xanthoma of skin 0 trials
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Xanthinuria 0 trials · 1 incl. sub-types
2 sub-types
- Hereditary xanthinuria 0 trials · 1 incl. sub-types Sub-types →
- Acquired xanthinuria 0 trials
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Collagenous sprue 0 trials
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Disorder of glutamate decarboxylase 0 trials
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Skeletal fluorosis 0 trials
Most studied deeper sub-types
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New enzyme therapy aims to reach the brain in hunter syndrome
Disease control OngoingResearchers are testing a new enzyme replacement therapy called GNR-055 in people with Hunter syndrome (MPS II), a rare inherited disorder that causes harmful sugar molecules to build up in the body. The trial enrolls about 32 patients, including those who have never had enzyme t…
Phase 2/3 • Sponsor: AO GENERIUM • Aim: Disease control
Last updated Sep 21, 2026 16:00 UTC
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New weekly shot could help diabetics shed pounds
Disease control OngoingThis Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…
Phase 3 • Sponsor: Pfizer • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Could a daily pill help kids with rare blood disorder?
Disease control OngoingThis study tests a drug called mitapivat in children aged 1 to 18 with pyruvate kinase deficiency, a rare genetic condition that causes red blood cells to break down too quickly, leading to anemia. The trial compares mitapivat to a placebo to see if it can raise hemoglobin levels…
Phase 3 • Sponsor: Agios Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Could a pill replace blood transfusions for kids with rare anemia?
Disease control OngoingThis phase 3 trial tests the drug mitapivat in children aged 1 to 18 with pyruvate kinase deficiency, a rare genetic disorder that causes red blood cells to break down too quickly. These children need regular blood transfusions. The study compares mitapivat to a placebo to see if…
Phase 3 • Sponsor: Agios Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Zapping the brain to reset mood and metabolism?
Disease control OngoingThis trial tests whether repetitive transcranial magnetic stimulation (rTMS) can improve both depression and related metabolic issues like insulin resistance. About 90 adults with major depression or bipolar disorder will receive rTMS to a brain area involved in mood and reward. …
Sponsor: National Cheng-Kung University Hospital • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Fixing sleep, fortifying hearts: a new trial tests the link
Disease control By invitation onlyThis trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…
Sponsor: Indiana University • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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New drug aims to fix calcium levels in rare genetic disease
Disease control OngoingThis study tests a new drug called encaleret against usual treatments for people with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1), which causes low blood calcium and high urine calcium. About 67 participants will receive either encaleret or stand…
Phase 3 • Sponsor: Calcilytix Therapeutics, Inc., a BridgeBio company • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New weekly shot could help diabetics with kidney trouble control blood sugar
Disease control OngoingThis study tests a once-weekly injection called retatrutide in 320 adults with type 2 diabetes and moderate to severe kidney disease who are not controlling their blood sugar well on insulin. Participants will receive either the drug or a placebo for about 14 months. The goal is …
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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Could a traditional Plant-Based diet curb diabetes risk in latino communities?
Disease control CancelledThis study tests whether a culturally tailored plant-based diet, guided by community health workers, can help Latino adults with obesity lose weight and improve metabolic health. Forty participants will be randomly assigned to either the plant-based diet program or standard healt…
Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New obesity drug CRB-913 enters human testing
Disease control OngoingThis study tests a new drug called CRB-913 for weight loss in people with obesity. It involves 252 participants and has two parts: first, measuring how the drug works in healthy adults, then comparing three doses against a placebo over 12 weeks. The goal is to check safety and ho…
Phase 1 • Sponsor: Corbus Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Soaking away Alzheimer's? heat therapy trial targets blood sugar and brain health
Disease control By invitation onlyThis study tests whether regular warm-water baths can improve blood sugar control and brain energy use in healthy adults aged 65 and older who are at risk for Alzheimer's disease. Over 10 weeks, 60 participants will soak in warm water three times a week. Researchers will measure …
Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New diabetes drug retatrutide takes on semaglutide in major trial
Disease control OngoingThis study tests a new weekly medicine, retatrutide, against an existing one, semaglutide, in about 1250 adults with type 2 diabetes whose blood sugar is not well controlled by metformin. The goal is to see which works better at lowering blood sugar and weight over 26 months. Par…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Could a higher dose of tirzepatide tackle diabetes and obesity together?
Disease control OngoingThis phase 2 trial tests different doses of tirzepatide in 414 adults with type 2 diabetes and obesity who already take metformin. The goal is to see if the drug helps with weight loss and blood sugar control. Participants receive either tirzepatide or a placebo for about 89 week…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Promising new treatment for rare sugar disorder moves to final testing phase
Disease control OngoingThis study tests an investigational drug called RZ358 for people with congenital hyperinsulinism, a rare condition causing dangerously low blood sugar. The trial involves 56 participants aged 3 months to 45 years who still have low blood sugar despite standard treatments. Over 24…
Phase 3 • Sponsor: Rezolute • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Gene therapy boost for krabbe patients after transplant
Disease control OngoingThis early-phase trial tests a single infusion of a gene therapy called FBX-101 in 9 people with Krabbe disease who have already received a stem cell transplant. The therapy uses a harmless virus to deliver a working copy of the GALC gene, aiming to improve motor function and saf…
Phase 1/2 • Sponsor: Forge Biologics, Inc • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Could a gut procedure help control diabetes? new trial investigates
Disease control PausedThis study tests a procedure called duodenal mucosal resurfacing (DMR) using the Revita system in people with type 2 diabetes whose blood sugar is not well controlled with medication. About 320 adults will be randomly assigned to receive either the real procedure or a sham (fake)…
Sponsor: Fractyl Health Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Heart specialist Check-Ins could save lives in GP surgeries
Disease control OngoingThis study tests whether having extra appointments with a heart specialist at a local GP practice helps people get better treatment for heart, kidney, metabolic, and lung conditions. 138 high-risk adults will either receive standard GP care or additional specialist reviews to opt…
Sponsor: University of Leeds • Aim: Disease control
Last updated Jun 26, 2026 17:32 UTC
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New imaging study aims to spot liver trouble in obese kids without needles
Diagnosis By invitation onlyThis study follows 300 children aged 9 to 14 with obesity to see if ultrasound and MRI can detect early signs of liver disease. Researchers will compare imaging markers like liver fat and stiffness with standard tests. The goal is to improve diagnosis and monitoring without invas…
Sponsor: Sahlgrenska University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 12:34 UTC
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Hidden heart risks: new screening program targets undiagnosed disease in cameroon
Diagnosis By invitation onlyThis study will screen 200 adults in urban Cameroon for undiagnosed cardiometabolic disease risk factors like high blood pressure, diabetes, and obesity. Participants will receive a simple health check to find hidden conditions. The goal is to improve early detection and connect …
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Jun 27, 2026 08:00 UTC
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Wearable tech could stop Post-Pregnancy diabetes in its tracks
Prevention OngoingThis trial tests whether giving women who had gestational diabetes a continuous glucose monitor and a FitBit can help them adopt healthier habits and prevent type 2 diabetes. Participants will wear the sensor for up to 14 days and use the tracker to monitor their activity. The st…
Sponsor: KK Women's and Children's Hospital • Aim: Prevention
Last updated Aug 08, 2026 00:03 UTC
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Can a Pre-Pregnancy lifestyle program boost mother and child health?
Prevention OngoingThis trial tests whether a comprehensive lifestyle program, called HELMS, can improve the health of overweight women and their children. The program starts before conception and continues through pregnancy and the first 18 months of the child's life, including health screenings, …
Sponsor: KK Women's and Children's Hospital • Aim: Prevention
Last updated Aug 08, 2026 00:03 UTC
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Could a simple injection stop type 1 diabetes before it starts?
Prevention OngoingThis phase II trial tests a drug called Diamyd, given as injections into lymph nodes, to see if it is safe and can prevent type 1 diabetes in children aged 8 to 17 who are at high risk. Only 5 participants are enrolled, and the study focuses on safety and whether the drug can sto…
Phase 2 • Sponsor: Diamyd Medical AB • Aim: Prevention
Last updated Jun 27, 2026 12:10 UTC
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Can a smartphone app lift the emotional burden of type 2 diabetes?
Symptom relief OngoingThis study tests a self-guided digital program called covivio to help adults with type 2 diabetes manage emotional distress tied to their condition. About 250 participants will either use the app alongside their usual care or continue with usual care alone. The goal is to see if …
Sponsor: Gaia AG • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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New study aims to find the best Weight-Loss surgery for fewer side effects
Symptom relief OngoingThis study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…
Sponsor: Mina Kamal Gergis Erian • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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Chilly vests reveal hidden fat secrets that could fight obesity
Knowledge-focused OngoingThis study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…
Sponsor: Rockefeller University • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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Can a simple questionnaire capture the true toll of metabolic surgery?
Knowledge-focused By invitation onlyResearchers at a South African hospital are asking whether two questionnaires can reliably capture how patients feel after metabolic surgery for obesity. Adults scheduled for the procedure will rate their comfort, pain, nausea, and return to normal activities before surgery and a…
Sponsor: Sefako Makgatho Health Sciences University • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Vitamin c may turn up your inner thermostat
Knowledge-focused OngoingThis study looks at whether vitamin C can increase body heat produced by the nervous system and boost vitamin D levels in the blood. Researchers will measure temperature and blood samples in 20 overweight adults aged 18-40 during a stimulation test. The goal is to understand how …
Sponsor: Colorado State University • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Short walks beat one big workout for Kids' health?
Knowledge-focused OngoingThis study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Gastric bypass secrets: intestine rewires metabolism
Knowledge-focused OngoingThis study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Massive genetic study aims to unlock secrets of rare metabolic diseases
Knowledge-focused By invitation onlyThis study will collect and analyze genetic data from 1000 people with suspected inherited metabolic diseases, including conditions like epilepsy and mitochondrial disorders. Researchers at Karolinska University Hospital aim to improve diagnosis by using advanced genetic testing …
Sponsor: Region Stockholm • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Pre-Pregnancy health linked to child development in major singapore study
Knowledge-focused OngoingThis study follows over 1,000 women in Singapore from before pregnancy through their child's early years. Researchers are looking at how nutrition, lifestyle, and emotional health before and during early pregnancy may influence the child's body composition, brain development, and…
Sponsor: KK Women's and Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Scientists use drinkometer to reveal how Weight-Loss drugs alter eating
Knowledge-focused OngoingThis study directly measures how GLP-1 medications (like Ozempic) change the way people eat. Researchers use a special device to track every sip of sugary and fatty drinks in 140 adults with obesity. The goal is to understand exactly how these drugs reduce calorie intake, not jus…
Sponsor: University College Dublin • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Is 'Safe' snus actually safe? 30,000-Person study aims to find out
Knowledge-focused OngoingThis study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advan…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Wilson disease patients sought for survey to shape gene editing research
Knowledge-focused OngoingThis study surveys 30 adults with Wilson disease to learn about their daily management, treatment adherence, and interest in gene editing clinical trials. By gathering this information, researchers hope to design better future studies for potential gene therapies targeting specif…
Sponsor: Prime Medicine, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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New Drug's journey through the body tracked in small study
Knowledge-focused OngoingThis early-stage study looks at how healthy postmenopausal women absorb, break down, and eliminate the experimental drug GS1-144. Six participants will take a single oral dose, and researchers will measure the drug and its byproducts in blood, urine, and stool. The goal is purely…
Phase 1 • Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Diet study hopes to tame gut inflammation in polyp patients
Knowledge-focused By invitation onlyThis study tests whether a two-week plant-based Mediterranean diet can change gut bacteria and reduce inflammation in people who have had colon polyps removed. Thirty participants will eat high-fiber meals delivered to their homes, and researchers will track changes in blood and …
Sponsor: University of California, San Diego • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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New biomarker study aims to improve outcomes for infants with rare heart condition
Knowledge-focused OngoingThis study measures certain substances in the blood (biomarkers) of infants with a rare heart defect called single-ventricle. The goal is to understand how these biomarkers relate to lung blood flow before and after a specific heart surgery (superior cavo-pulmonary anastomosis). …
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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New study monitors rare calcium disorder to better understand its long-term effects
Knowledge-focused OngoingThis study is for people with autosomal dominant hypocalcemia types 1 or 2, rare genetic conditions that cause low blood calcium. Researchers will collect past and future health data from 95 participants to learn how the disease changes over time. The goal is to better understand…
Sponsor: Calcilytix Therapeutics, Inc., a BridgeBio company • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Toronto study links Mom's gut bugs to Baby's future health
Knowledge-focused OngoingThis study looks at how the bacteria in a pregnant woman's gut (her microbiome) and her nutrition affect her baby's growth and health. Researchers are following 800 young pregnant women (28 and under) in Toronto throughout pregnancy and for a year after birth. They collect stool,…
Sponsor: The Hospital for Sick Children • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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100,000 families join landmark study on parental exposures and child health
Knowledge-focused OngoingThis study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers collect health data, biospecimens, and environmental information to understand how parents' exposures affect pregnancy outcomes and child development. The goal is to f…
Sponsor: National Research Institute for Family Planning, China • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Scientists hunt for Muscle's secret Fat-Burning signals
Knowledge-focused OngoingThis study looks at how exercise changes the signals muscles send to the rest of the body, especially those that help burn fat. Researchers will compare obese, lean, and athletic participants to find proteins or genetic codes released from muscle during exercise. The goal is to b…
Sponsor: AdventHealth Translational Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Massive 10-Year health check: what happens when chronic diseases collide?
Knowledge-focused By invitation onlyThis study follows over 50,000 Chinese adults who were first surveyed between 2011 and 2014. Researchers will check how chronic lung, heart, metabolic diseases, and cancers have developed or changed over more than a decade. The goal is to understand how multiple health problems o…
Sponsor: China-Japan Friendship Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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20-Year study to unlock secrets of pregnancy and child health
Knowledge-focused OngoingThis study follows about 1,200 mothers from early pregnancy and their children for at least 20 years. Researchers want to learn how genetics, diet, lifestyle, and environment during pregnancy and early childhood affect the risk of metabolic and mental health conditions later in l…
Sponsor: National University Hospital, Singapore • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Genes may determine how your body handles food and metformin
Knowledge-focused OngoingThis study looks at whether certain genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will take a special drink and then have their blood sugar and other markers measured. The goal is to u…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC