Lens disorder

This study is testing a new type of artificial lens, called the Clareon TruPlus, for people having cataract surgery. The lens is placed inside the eye to replace the cloudy natural lens and help restore clear vision. About 122 adults with cataracts and astigmatism will receive th…

This study tests a new multifocal lens (LuxHighAdd) for cataract surgery, comparing it to a standard monofocal lens. About 57 people aged 50+ with cataracts in both eyes will receive the lens in both eyes. The goal is to see if the new lens improves near vision without harming di…

This study is testing a new type of intraocular lens (IOL) that can be adjusted after cataract surgery using laser energy, potentially allowing the eye to focus at different distances. Researchers will enroll 85 adults with cataracts in both eyes to check safety and how well the …

This Phase 3 trial tests pegtibatinase, an enzyme given as a shot, in 70 people aged 12–65 with classical homocystinuria. The goal is to see if it safely lowers high homocysteine levels when added to standard care. Participants receive either the drug or a placebo for 24 weeks.

This study tests whether placing a capsular tension ring (CTR) during cataract surgery helps keep the artificial lens more stable in people with retinitis pigmentosa (RP). Each of the 88 participants will get the ring in one eye, while the other eye serves as a comparison. Resear…

This study is testing a special laser called ELIOS to treat glaucoma at the same time as cataract surgery. The laser creates tiny channels in the eye to help fluid drain and lower eye pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal i…

This study is testing a new robotic system called ORYOM to see if it can safely perform cataract surgery. Twenty adults between 55 and 80 years old who need cataract surgery will take part. The main goal is to see if the robot can complete the surgery without needing to switch to…

This study tests a toric add-on lens placed in the eye to correct high astigmatism in people who have already had a corneal transplant and cataract surgery. The goal is to reduce blurry vision from astigmatism without removing the original lens. About 40 participants will be foll…

This study tests a device called the Tran cannula, used during cataract surgery to clean away debris from the eye's drainage system in patients with pseudoexfoliative glaucoma. The goal is to see if it lowers eye pressure better than standard irrigation. Fifty-eight adults with b…

This study tests whether a custom-made lens implanted during cataract surgery can better correct vision in people with irregularly shaped corneas. Fifteen adults with significant astigmatism will receive the special lens. The goal is to reduce total astigmatism and improve visual…

This study tests a small device called iStent that is placed in the eye during cataract surgery to help lower pressure in people with open-angle glaucoma. Sixty adults with both glaucoma and cataracts will be enrolled. The goal is to see if the iStent is safe and effective at red…

This study is checking the long-term safety of the IC-8 Apthera lens, which is implanted during cataract surgery. It focuses on a common complication called posterior capsule opacification (PCO), where the lens capsule becomes cloudy. Researchers will follow 435 people for 24 mon…

This study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in patients with additional eye structure issues like lens dislocation or inflammation. About 320 adults will receive these lenses during cataract surgery, with doct…

This early study is testing a robot-assisted system for cataract surgery in 30 adults aged 40 to 75. The robot is designed to help surgeons be more precise and improve safety compared to standard surgery. The main goal is to check for any eye-related side effects. If it works wel…

This Phase 3 trial tests a new eye drop called PRO-232, which combines an antibiotic (moxifloxacin) and a steroid (dexamethasone) in one bottle. It aims to see if this single drop works as well as using two separate drops to prevent infection and control inflammation after catara…

This study tests whether making tiny arcuate incisions on the cornea during cataract surgery, combined with a special light-adjustable lens, can better correct pre-existing astigmatism. About 60 adults will receive this treatment and be followed to see how much their vision impro…

This early-stage trial tests a new treatment called EO2002, which uses magnetic human corneal cells injected into the eye during or after cataract surgery. The goal is to see if it is safe and tolerable for patients with low corneal cell counts. The study involves 32 participants…

This study tests a new surgery that uses tiny hooks to reposition a dislocated lens in the eye without stitches. The procedure aims to improve vision and reduce complications. Researchers will enroll 40 adults with lens subluxation and track their eyesight and lens position for u…

This study compares two types of trifocal toric lens implants used during cataract surgery to correct both cataracts and astigmatism. About 138 adults with cataracts and regular astigmatism will receive one of the two lenses. The main goal is to see which lens provides better int…

This study tests whether adding pilocarpine eye drops after combined cataract and Kahook Dual Blade surgery helps lower eye pressure more than standard drops alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients achieve a 2…

This phase 3 trial tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant with a special lens or standard eye drops. The goal is to see if…

This study tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant plus a special lens or standard eye drops. The goal is to see if the imp…

This study is testing a new device called the Veritas Vision System for cataract surgery. The goal is to see if it uses less energy and causes less damage to the cells on the inside of the eye. Researchers will follow 50 adults for 3 months after surgery to check eye health and v…

This study tests special eye drops made with stem cells to see if they can help people with dry eye disease and cataracts. Researchers will give 300 adults these drops three times a day for 12 weeks. They will check if the drops improve tear film, reduce symptoms, and clear up th…

This study compares three different NSAID eye drops (bromfenac, nepafenac, and diclofenac) to see which one best prevents cystoid macular edema, a type of swelling that can blur vision after cataract surgery. About 150 adults having cataract surgery will be randomly assigned to o…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…

This study is testing whether artificial intelligence can analyze eye images to better detect and predict vision-threatening changes in people with high myopia (severe nearsightedness). Researchers will collect eye scans from 1,000 patients and use AI to identify a condition call…

This study is testing whether creating a full 3D model of the eye can help doctors better plan surgeries for people with complex cataracts and eye structure problems. Researchers will combine scans from multiple imaging tools to build the model. The goal is to improve surgical ac…

This study is testing whether an AI-based eye screening program can help detect glaucoma and other eye conditions in people visiting community health centers. About 1,800 adults at higher risk for glaucoma will get a quick eye scan using an AI tool called AI-RONA. If the screenin…

This study tests a new type of lens called Clareon TruPlus, used during cataract surgery to replace the eye's natural lens. Researchers want to see how well it improves vision and how satisfied patients are up to 3 months after the procedure. The study involves 40 adults over 40 …

This study tests new versions of Clareon Vivity Pro intraocular lenses (IOLs) to see if they improve vision better than current lenses. About 231 adults with cataracts in both eyes will receive one new lens and one current lens to compare results. The main goal is to measure how …

This study looks at the best way to fix a detached retina, a serious eye problem that can cause vision loss. It compares doing one surgery (vitrectomy) alone versus doing it together with cataract surgery at the same time. The goal is to see which approach gives better vision, fe…

This study tests the Clareon TruPlus lens in 35 adults over 45 who need cataract surgery and previously had laser eye surgery for nearsightedness. The lens is designed to improve vision at various distances and reduce the need for glasses. Participants will be followed for 3 mont…

This study looks at whether playing binaural beats (a type of sound) through earphones during cataract surgery can help older patients feel more satisfied and comfortable. About 60 people aged 65 and older will take part, with half listening to the sounds and half wearing earphon…

This study tests whether a web-based visual training program can improve vision in children aged 4-12 who had surgery for a rare lens dislocation condition called congenital ectopia lentis. Over 3 months, 82 children will use the training software for 30 minutes daily. Researcher…

This study compares three sedation approaches—using dexmedetomidine, propofol, or both—during cataract surgery in 1,000 adults. Researchers will measure how well each method sedates patients, affects heart rate and blood pressure, and causes side effects like nausea. The goal is …

This study looks at whether taking an oral anti-anxiety medication (Alprazolam) before cataract surgery can reduce pain and anxiety and improve satisfaction. Researchers will follow 250 adults having surgery on their second eye. The goal is to find a safe, convenient way to make …

This study looks at whether Systane COMPLETE artificial tears can improve dry eye symptoms and help doctors better predict cataract surgery outcomes. About 140 cataract patients with dry eye will use the drops before and after surgery. Researchers will measure changes in eye shap…

This study looks at whether taking Xanax (a mild anti-anxiety medication) 30 minutes before cataract surgery can reduce pain and anxiety and improve satisfaction with the anesthesia. Researchers will compare Xanax to a placebo in 400 adults having cataract surgery at National Tai…

This study tests whether using Systane COMPLETE eye drops before cataract surgery can improve dry eye symptoms and help with surgical planning. About 150 adults aged 20-85 with dry eye who need cataract surgery will use the drops regularly before their operation. Researchers will…

This study tests whether a medication given as a nose spray (dexmedetomidine) can keep blood pressure stable in elderly patients with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will take part. The goal is to see if the spray reduces da…

This study tests a new, gentler way to remove cataracts (cloudy lenses) using high-frequency pulsed vacuum instead of the usual ultrasound. The goal is to see if it causes less damage to the eye's inner lining, leading to faster recovery and fewer risks. Sixty adults with catarac…

This study compares two different materials used in multifocal lenses for cataract surgery. 40 people will receive one type of lens in each eye. The goal is to see which lens provides better contrast sensitivity (ability to see differences in light and dark) 3 months after surger…

This study tests a new type of lens implant (extended depth of focus IOL) for people with age-related cataracts. The lens is designed to provide clear vision at multiple distances, potentially reducing the need for glasses after surgery. About 220 adults will be randomly assigned…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will measure pai…

This study tests a new type of artificial lens (LuxBoost) for people having cataract surgery. The goal is to see if it improves vision at far, middle, and close distances compared to a standard lens. About 58 adults aged 50 and older with cataracts in both eyes will take part.

This study tests whether having a researcher hold the patient's hand or giving them a stress ball to squeeze can reduce pain and anxiety during cataract surgery. 108 adults having their first cataract surgery will be randomly assigned to one of three groups: hand holding, stress …

This study compares two types of special lenses (Rayone EMV and Vivinex Impress XY1-EM) used in cataract surgery to improve vision at different distances. About 100 adults with age-related cataracts will receive these lenses in both eyes. The goal is to see which lens provides be…

This study tests whether a 10-minute educational video can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to watch the video or receive only standard instructions. Researchers will measure anxiety level…

This study looks at whether giving melatonin under the tongue before cataract surgery can reduce anxiety and help older adults relax. Sixty people aged 60 and older will receive either melatonin or a placebo. The goal is to find a safer alternative to standard sedatives that may …

This study looks at how well a specific lens implant (Clareon PanOptix Pro) works during cataract surgery for people who previously had LASIK or PRK to correct nearsightedness. About 40 adults aged 45 and older will receive the implant in both eyes and be followed for 3 months. T…

This study compares standard monofocal intraocular lenses (IOLs) with enhanced monofocal IOLs in 461 people having cataract surgery. The goal is to see if the enhanced lenses improve vision at intermediate distances, like reading a computer screen, while maintaining good distance…

This study looks at how well a new type of cataract lens works for people who had LASIK surgery in the past. Cataracts cause blurry vision, and this lens is designed to help with seeing clearly at all distances. The study will involve 30 adults aged 50 and older who need cataract…

This study compares having cataract surgery on both eyes the same day versus waiting weeks between surgeries. Researchers want to see if same-day surgery is just as safe, costs less, and improves quality of life. About 242 adults in France with cataracts in both eyes will take pa…

This study tests whether keeping the eye at a lower pressure during cataract surgery helps reduce swelling and improve vision right after the procedure. About 105 people with cataracts will have one eye operated on with a standard pressure system and the other with a lower pressu…

This study tests a gel placed in the tear ducts before cataract surgery to see if it helps dry eye symptoms. Sixty adults with dry eye will receive the gel and be followed for up to 5 months. The main goal is to measure tear film stability, a key sign of eye moisture.

This study compares two types of advanced lens implants (Clareon Vivity and PureSee) used in cataract surgery. Researchers want to see which lens provides better vision at far, intermediate, and near distances. The trial involves 80 adults aged 50 and older who need cataract surg…

This study investigates whether a small RNA molecule called tRF-31 is linked to the severity of age-related cataracts. Researchers will collect lens tissue from 200 adults undergoing routine cataract surgery and measure tRF-31 levels. The goal is to see if higher or lower levels …

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study looks at whether dry eye disease affects the accuracy of corneal measurements needed for cataract surgery planning. 400 cataract patients will be divided into those with and without dry eye. Those with dry eye will use sodium hyaluronate eye drops for two weeks. Resear…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study looks at 300 people having cataract surgery to see if where the surgeon places the phacoemulsification tip (the tool that breaks up the cataract) affects early healing. Researchers will use a special camera during surgery to track the tip's location and then measure co…

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study is testing a new device called Unity DX that measures the eye's shape and focus. The goal is to collect data to help plan cataract surgeries more accurately. About 400 people having cataract treatment will participate. This is a data-gathering study, not a treatment it…

This study follows 60,000 people with cataracts, including those with high myopia (severe nearsightedness), to see how their vision changes after cataract surgery. Researchers will also look at genetic and environmental factors that might affect cataract development and surgical …

This study looks at whether improving how hospital wards and operating rooms work together can reduce waiting times for cataract surgery. Researchers will observe 360 patients aged 20 and older at a single eye hospital, track delays and errors, then test new procedures to see if …

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

This study looks at 90 cataract patients who also have an epiretinal membrane (a thin layer on the retina). Researchers want to see if a special "functional" lens implant helps them see better without glasses compared to a standard lens. Participants will have their vision checke…

This study looks back at the results of cataract and vision correction surgeries in 150 adults. Researchers will compare different types of artificial lenses and surgical methods to see which ones give the best vision and fewest complications. The goal is to gather information th…

This study compares two different machines used during cataract surgery to see which one uses less ultrasound energy. The researchers will measure the total energy delivered into the eye while removing the cloudy lens. Thirty adults with cataracts in both eyes will take part, wit…

This study looks at fluid and tissue samples from the eyes of people with glaucoma and cataracts, and compares them to samples from people with cataracts only. The goal is to find chemical and protein patterns that could help doctors diagnose or track glaucoma better in the futur…

This study tracks 400 adults with cataracts to see how three different toric intraocular lenses rotate after surgery. Rotation is measured at several follow-up visits over three months. The goal is to find which lens stays most stable and help doctors choose the best option for e…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study involves 80 adults who have had cataract surgery and received special lens implants that correct presbyopia (age-related blurry near vision). Researchers will use a 3-D eye scanner and a wavefront sensor to measure how well these lenses focus light onto the retina. The…

This study is testing a new way to measure eye pressure during cataract and glaucoma surgery. Researchers will use a special sensor to track pressure changes and see if this helps predict and prevent problems after surgery. The study involves 150 adults having these surgeries at …

This study compares two surgical systems used for combined cataract and vitrectomy eye surgeries. The UNITY VCS system is being tested against the CONSTELLATION system to see which one surgeons find more efficient in real-world operating rooms. About 180 adults needing combined e…

This study looks at a hand-held laser used during cataract surgery to see if it keeps the risk of capsule tears below 2%. Researchers will review medical records of 446 adults who had cataract surgery with this laser as part of their regular care. The goal is to confirm how safe …

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study is testing a new optical biometer called Helioscope that measures key eye dimensions in people with cataracts. The goal is to see if it can accurately measure the eye's shape and length, which helps surgeons pick the right lens implant during cataract surgery. About 10…

This study tests a new digital guidance system that helps surgeons place toric lenses more accurately during cataract surgery. Researchers will compare the system's alignment calculations to standard methods and check vision and astigmatism one month after surgery. The study invo…

This study looks at how to better diagnose and treat dry eye before cataract surgery to help people see better after the operation. About 110 adults with dry eye will be followed to find the best ways to prepare the eye surface. The goal is to create clear guidelines that eye doc…

This study is a patient registry that collects information from 300 people who have had or will have cataract surgery with different types of artificial lens implants. The goal is to compare how well people see at various distances after surgery with each lens type. No new treatm…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study is looking at how general anesthesia affects blood pressure and eye pressure in people aged 65-85 having cataract surgery. Researchers will also check if frailty plays a role. The goal is to better understand these changes to improve safety for older patients.

This study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study tests three AI chatbots—ChatGPT 4o, GPT-5, and DeepSeek—on their ability to read eye scans from 100 cataract patients. The AI will try to extract key measurements, recommend the right lens implant, and predict vision after surgery. No treatment is given; the goal is to…

This study will compare different laser techniques used in eye surgeries for cataracts and myopia. Researchers want to see which method causes less inflammation and oxidative stress, and leads to better vision recovery. 1,000 patients will be followed for three months after surge…