Lens disorder

This study compares two surgical techniques for removing very hard cataracts, which are tough to break apart and can lead to complications like corneal swelling or lens rupture. The new method, called 'divide and conquer with debulking,' aims to make the procedure safer. Research…

This study tests a new artificial lens, called an intraocular lens (IOL), placed in the eye during cataract surgery. The lens is designed to replace the eye's natural lens and help restore vision. Researchers will measure how clearly participants see one year after surgery and ch…

This study tests a new type of artificial lens for cataract surgery that may adjust focus like a natural lens. About 100 adults needing cataract surgery will get this lens in one eye and a standard lens in the other. Researchers will check for complications and measure vision imp…

This study tests a new trifocal intraocular lens (IOL) for people having cataract surgery. The lens is designed to help see clearly at near, intermediate, and far distances. Researchers will compare the new lens to a commercially available one in 66 participants, measuring distan…

This trial tests two different needle insertion spots during YAMANE surgery, a procedure to fix a lens in the eye for children with congenital ectopia lentis (a condition where the eye's lens is out of place). Researchers will compare how accurate the lens placement is and how we…

This study tests whether using EPD-09-25 eyelid wipes before and after cataract surgery can reduce bacteria on the eyelid and improve dry eye symptoms. One hundred adults scheduled for cataract surgery will either use the wipes twice daily for five weeks or receive no special eye…

This study tests whether silver diamine fluoride or silver fluoride, sometimes with a special LED light, can stop early cavities in the back teeth of young adults. About 366 high-risk dental students will receive one of these treatments. The goal is to see which approach works be…

This study tests whether low-dose atropine eye drops (0.05%) can slow down worsening nearsightedness in children aged 1 to 7 who have had cataract surgery with an artificial lens implant. Fifty children will receive the drops for 12 months, and researchers will measure changes in…

This study looks at whether a single injection of the drug Aflibercept given during cataract surgery works as well as three injections (one during surgery and two more over the next two months) to stop diabetic retinopathy from getting worse. The trial will include 166 diabetic p…

This study tests two different needle insertion spots (2mm vs 2.5mm from the eye's edge) for a special lens implant surgery in children aged 4-18 with congenital ectopia lentis, a condition where the eye's natural lens is out of place. The goal is to see which spot gives better v…

This trial tests whether an enhanced monofocal intraocular lens, set for monovision (one eye for distance, one for near), improves vision without glasses in people with both cataracts and high myopia. Sixty-six participants will receive the lens in both eyes and be followed for o…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This study will test whether a single antibiotic injection given during cataract surgery can prevent endophthalmitis, a rare but severe eye infection. About 60,000 people with cataracts will receive either the antibiotic or a placebo. The goal is to see if the antibiotic reduces …

This study tests a 3D-printed 'oxygen support cage' placed over the patient's head during cataract surgery. The cage lifts surgical drapes off the face, which may reduce feelings of suffocation and anxiety. Researchers will measure changes in blood pressure, heart rate, breathing…

This study compares two types of artificial lens implants used in cataract surgery: the Clareon TruPlus and the Tecnis Eyhance. Researchers want to see which lens gives better vision at different distances and how satisfied patients are. The study involves 70 adults with cataract…

This study looks at whether a gel-like filler placed in the tear ducts can improve dry eye symptoms and make eye measurements more accurate before cataract surgery. About 65 adults with dry eye disease will be observed. The goal is to see if treating dry eye first leads to better…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the real surgery. About 260 adults scheduled for cataract surgery will either use VR glasses to experience the sights and…

This study tests whether placing surgical cuts in specific parts of the cornea during cataract surgery can reduce astigmatism (blurry vision from an irregularly shaped cornea) and lower the need for glasses afterward. About 100 people with cataracts and astigmatism will be random…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the actual surgery. Sixty adults scheduled for cataract surgery will either watch the VR video or receive standard care. …

This study will observe 300 adults who have cataract surgery to see which of three tear substitute eye drops works best for reducing dry eye and discomfort. The drops contain different combinations of sodium hyaluronate, dexpanthenol, trehalose, and amino acids. Researchers will …

This study tests whether the sedative remimazolam can reduce complications and shorten recovery time after cataract surgery. Researchers will enroll 30 adults aged 55 to 90 who need surgery on both eyes. The goal is to see if this drug leads to fewer side effects and faster disch…

This study compares two ways to manage pain and swelling after cataract surgery. One uses a single injection and two types of eye drops, the other uses three different drops multiple times a day. 40 adults having surgery on both eyes will try each method and say which they prefer…

This study tests a special lens used during cataract surgery to see how well it improves vision. About 130 adults with cataracts will get the lens and have their eyesight checked afterward. The goal is to make sure the lens is safe and helps people see more clearly.

This study will test a new type of artificial lens, called the PureSee IOL, in 10 people who need surgery for both cataracts and a cornea condition called Fuchs dystrophy. The goal is to see if this lens helps patients see well at different distances and reduces their need for gl…

This study will test whether a special type of lens implant (extended depth-of-focus, or EDOF) can give better vision and more satisfaction than standard monofocal lenses for people with both glaucoma and cataracts. About 74 adults with early-to-moderate open-angle glaucoma will …

This study compares two ways of doing cataract surgery to find out which one helps people see better the day after the operation. The researchers will test a newer method that keeps the surgery inside the lens capsule, hoping it causes less damage to the eye's inner lining. About…

This study tests a new method called Zero CDE for cataract surgery. It uses a special laser to break up the cloudy lens into tiny pieces that can be removed without using much energy. The goal is to see if this technique leads to fewer side effects and quicker recovery. About 90 …

This study compares two common eye drops—rebamipide and diquafosol—for managing dry eye in people having cataract surgery. Sixty adults with mild to moderate dry eye will use one of the drops four times a day, starting one month before surgery and continuing for three months afte…

This study looks at whether giving sedation (medication to help you relax) during cataract surgery improves patient comfort and satisfaction. About 120 adults having cataract surgery under numbing eye drops will be randomly placed into one of three groups: no sedation, mild sedat…

This study tests a new surgical gel, IXIUM TWIN, designed to protect the eye during cataract surgery. About 180 adults having cataract surgery will receive either the new gel or an approved one to see if it causes less damage to the eye's inner lining. The goal is to offer surgeo…

This study will compare two enhanced monofocal intraocular lenses (IOLs) used in cataract surgery to see which one provides better vision at intermediate distances, like reading a computer screen. Thirty adults with age-related cataracts will receive one of the two lenses, and th…

This study looks at whether keeping eye pressure more natural during cataract surgery helps patients feel less pain and need fewer pain medicines. About 85 people having cataract surgery in both eyes will take part. The goal is to see if a higher, more normal pressure makes the s…

This study looks at why many people in rural Assam who are referred for eye care don't make it to the hospital for treatment. Researchers will test new ways to help patients complete their referrals, like providing transport and reminders. The goal is to increase the number of pe…

This study will analyze eye and brain scans from over 200,000 people to see if eye images can predict brain diseases like small vessel disease and other health problems. Researchers will build computer models to map eye features to brain structure and disease diagnoses. No treatm…

This study tests whether asking people to write down their personal reasons for or against cataract surgery helps them make a clearer decision. About 268 adults with cataracts will be randomly assigned to either do this writing exercise or not. Researchers will then track how man…

This study looks at whether dry eye disease makes it harder to calculate the right lens power for cataract surgery. Researchers will compare 100 patients with and without dry eye to see if those with dry eye have less accurate lens measurements. The goal is to find out if treatin…

This study looks at why some eye centers in rural India have better rates of follow-up after cataract surgery than others. Researchers will study 150 patients and staff at about 120 vision centers to find what works. Then they will test a package of improvements—like reminders, c…

This study will compare two common anesthesia methods—propofol and sevoflurane—in 40 people having cataract surgery. The goal is to see which one keeps eye pressure more stable and causes fewer heart-related side effects. Researchers will measure eye pressure repeatedly during th…

This study looks at whether using a device that helps see veins under the skin can make placing an IV in children faster and with fewer needle sticks. About 500 children under 18 who need an IV for day surgery or other procedures will take part. Researchers will compare the time …

This study will check the eyes of 3,000 people in Xinxing County, including schoolchildren, seniors, and people with diabetes. The goal is to measure how common vision problems like nearsightedness and cataracts are, and how well they are being treated. Participants will have sim…

This study aims to improve how doctors calculate the power of artificial lenses used in cataract surgery. Researchers will use several imaging devices and artificial intelligence to better estimate lens size and position. The goal is to help patients see more clearly after surger…