Congenital primary aphakia
MONDO:0012456Congenital primary aphakia (CPA) is characterized by an absence of the lens. The prevalence is unknown. CPA can be associated with variable secondary ocular defects (including aplasia/dysplasia of the anterior segment of the eye, microphthalmia, and in some cases absence of the iris, retinal dysplasia, or sclerocornea). CPA results from early developmental arrest, around the 4th-5th week of embryogenesis, which prevents the formation of any lens structure. Mutations in the FOXE3 gene were identified in three affected siblings born to consanguineous parents.
Also known as: anterior segment dysgenesis 2, multiple subtypes, aphakia, congenital primary, congenital absence of lens, congenital aphakia, ASGD2, CPA, anterior segment dysgenesis 2
18 clinical trials for this condition and its sub-types.
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New lens implant aims to sharpen sight after cataracts
Disease control Recruiting nowThis study is testing a new type of artificial lens, called the Clareon TruPlus, for people having cataract surgery. The lens is placed inside the eye to replace the cloudy natural lens and help restore clear vision. About 122 adults with cataracts and astigmatism will receive th…
Phase: NA • Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New eye lens could let you focus without glasses after cataract surgery
Disease control Recruiting nowThis study is testing a new type of intraocular lens (IOL) that can be adjusted after cataract surgery using laser energy, potentially allowing the eye to focus at different distances. Researchers will enroll 85 adults with cataracts in both eyes to check safety and how well the …
Phase: NA • Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New lens implants promise clearer vision for complex cataract cases
Disease control Recruiting nowThis study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in patients with additional eye structure issues like lens dislocation or inflammation. About 320 adults will receive these lenses during cataract surgery, with doct…
Phase: NA • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New lens aims to sharpen sight at all distances
Symptom relief Recruiting nowThis study tests a new type of artificial lens (LuxBoost) for people having cataract surgery. The goal is to see if it improves vision at far, middle, and close distances compared to a standard lens. About 58 adults aged 50 and older with cataracts in both eyes will take part.
Phase: NA • Sponsor: Cutting Edge SAS • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC