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Congenital primary aphakia
MONDO:0012456Congenital primary aphakia (CPA) is characterized by an absence of the lens. The prevalence is unknown. CPA can be associated with variable secondary ocular defects (including aplasia/dysplasia of the anterior segment of the eye, microphthalmia, and in some cases absence of the iris, retinal dysplasia, or sclerocornea). CPA results from early developmental arrest, around the 4th-5th week of embryogenesis, which prevents the formation of any lens structure. Mutations in the FOXE3 gene were identified in three affected siblings born to consanguineous parents.
Also known as: anterior segment dysgenesis 2, multiple subtypes, aphakia, congenital primary, congenital absence of lens, congenital aphakia, ASGD2, CPA, anterior segment dysgenesis 2
25 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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PanOptix lens safety confirmed years after surgery
Disease control CompletedThis study looked at the long-term safety and performance of AcrySof PanOptix trifocal lenses in 211 people who had them implanted in both eyes 3 to 5 years earlier. Researchers checked vision and recorded any eye problems or device issues. The goal was to make sure these lenses …
Phase: NA • Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New lens implant aims to sharpen vision at all distances
Symptom relief CompletedThis study tested a newer trifocal lens implant (Clareon PanOptix Pro) against an older one (Clareon PanOptix) in 71 adults having cataract surgery in both eyes. Each person got one of each lens, so their eyes could be compared directly. The goal was to see if the newer lens prov…
Phase: NA • Sponsor: Alcon Research • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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New lens vs. old lens: which gives sharper sight after cataract surgery?
Symptom relief CompletedThis study tested two different trifocal lens implants used during cataract surgery to see which one gives better vision. 87 people who needed cataract surgery in both eyes received one type of lens in each eye. The main goal was to measure how clearly they could see letters on a…
Phase: NA • Sponsor: Alcon Research • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Cataract lens study checks vision quality after surgery
Knowledge-focused CompletedThis study looked at how well the Clareon Vivity and Vivity Toric intraocular lenses work in people who already had cataract surgery. Researchers measured vision at different distances in 155 participants. The goal was to confirm the lenses perform as expected and support their u…
Phase: NA • Sponsor: Alcon Research • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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AI eye chatbot matches doctors in taking patient history
Knowledge-focused CompletedThis study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …
Phase: NA • Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC