Congenital primary aphakia
MONDO:0012456Congenital primary aphakia (CPA) is characterized by an absence of the lens. The prevalence is unknown. CPA can be associated with variable secondary ocular defects (including aplasia/dysplasia of the anterior segment of the eye, microphthalmia, and in some cases absence of the iris, retinal dysplasia, or sclerocornea). CPA results from early developmental arrest, around the 4th-5th week of embryogenesis, which prevents the formation of any lens structure. Mutations in the FOXE3 gene were identified in three affected siblings born to consanguineous parents.
Also known as: anterior segment dysgenesis 2, multiple subtypes, aphakia, congenital primary, congenital absence of lens, congenital aphakia, ASGD2, CPA, anterior segment dysgenesis 2
25 clinical trials for this condition and its sub-types.
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New lens implants promise clear vision at all distances after cataract surgery
Disease control OngoingThis study tests two types of advanced lens implants (IOLs) for people having cataract surgery in both eyes. The lenses are designed to help see clearly at far, arm's length, and near distances. Researchers will check safety and how well the lenses work in 110 participants over t…
Phase: NA • Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New lens aims to correct both cataracts and astigmatism in one go
Disease control OngoingThis study is checking the long-term safety and performance of a special lens called the Clareon Toric IOL, which is implanted during cataract surgery to also correct astigmatism. About 129 people with cataracts and astigmatism are taking part. The main goal is to see how well th…
Phase: NA • Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 26, 2026 18:23 UTC
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Eye scanner software update put to the test
Knowledge-focused OngoingThis study compares a new software version (1.5) of the ANTERION eye imaging device against the older cleared version (1.2.4). Researchers will check if the new software gives consistent and accurate measurements of eye structures like cornea thickness and lens thickness. The stu…
Sponsor: Heidelberg Engineering GmbH • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Free eye tests aim to catch vision loss early in harlem and washington heights
Knowledge-focused OngoingThis study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…
Phase: NA • Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Eye lens implant safety study pulled before starting
Knowledge-focused TerminatedThis study was designed to check the long-term safety and performance of AcrySof IQ Vivity lens implants in people who had them in both eyes for 3 to 5 years. It was a real-world observation, not a treatment test. However, the study was withdrawn before enrolling any participants…
Phase: NA • Sponsor: Alcon Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:27 UTC