Childhood malignant neoplasm

This study tests a program called CHEF that helps childhood cancer survivors and their families cook and eat healthy foods. The goal is to support heart health after cancer treatment. About 17 children who finished chemotherapy or radiation will take part. Researchers will measur…

This trial is testing an experimental drug called ONO-4538HSC (nivolumab) in children with advanced solid tumors that have not responded to standard treatments, and in patients with epithelioid sarcoma. The goal is to see if the drug is safe, tolerable, and effective at shrinking…

This trial tests a procedure to remove and freeze ovarian tissue from children and young adults under 30 who face treatments that may harm their fertility, such as chemotherapy, radiation, or surgery. The goal is to store the tissue for future use to restore fertility and hormone…

This study tests a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have returned after standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have a specific genetic c…

This study tests a new treatment called BCB-276 for children and young adults with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. BCB-276 is made from a patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The tr…

This trial tests whether a new drug called albipagrastim alfa can prevent severe neutropenia (dangerously low white blood cell counts) in children with sarcoma who are receiving chemotherapy. The drug is designed to stimulate the body's production of infection-fighting neutrophil…

This study tests whether giving the targeted drug selpercatinib for 6 months before standard radioactive iodine therapy can improve outcomes for children, adolescents, and young adults (ages 2-25) with a specific type of thyroid cancer linked to RET gene fusions. The goal is to s…

This early-stage study tests a new drug called CBA-1205 in people with advanced solid tumors (like liver cancer or melanoma) that have not responded to other treatments. The main goal is to check the drug's safety and find the best dose. About 66 participants will receive the dru…

This study is testing a combination of four drugs—atezolizumab, sorafenib, bevacizumab, and cyclophosphamide—in children and young adults with solid tumors that have come back or not responded to standard treatment. The goal is to find safe doses and see if the combination can sh…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or grown after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor tissue. The main goal is to see how many…

This early-stage trial is testing a new type of cell therapy called B7H3-IL7Ra CAR T-cells in children and young adults (ages 1-25) whose solid tumors have returned or not responded to standard treatments. The therapy uses the patient's own immune cells, modified in a lab to bett…

This trial tests whether giving children and teens with advanced solid tumors, brain tumors, or lymphomas drugs that match their tumor's genetic profile can help. About 90 participants will receive one of four drug combinations based on their tumor's molecular features. The goal …

This study tests an oral drug called LAM561 in children under 18 with advanced brain tumors (like high-grade glioma) or other solid tumors that have not responded to standard treatments. The trial has two phases: first, finding a safe dose in up to 18 children, then testing that …

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer tumors absorb more RAI, potentially improving treatment. It includes 32 children and teens with metastatic differentiated thyroid cancer that has spread to the lungs. Researcher…

This phase 2 trial tests whether giving larotrectinib for 6 months can make thyroid cancer cells more responsive to radioactive iodine therapy. It enrolls 13 children and young adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is t…

This study is testing a combination of three drugs—pucotenlimab (an immunotherapy), lenvatinib (a targeted therapy), and irinotecan (chemotherapy)—in children aged 2-18 with advanced or relapsed/refractory hepatoblastoma, a rare liver cancer. The goal is to see if this combinatio…

This study looks at whether a wearable heart monitor and a symptom questionnaire can accurately detect autonomic dysfunction—a condition affecting heart rate and blood pressure control—in survivors of childhood leukemia and lymphoma. Researchers will compare these remote methods …

This study tests a simple questionnaire to help doctors identify sexual health concerns in teenagers and young adults who have or had childhood cancer. The goal is to improve communication between patients and providers. About 205 participants aged 15-24 will use the screening to…

This phase 3 trial tests whether a fluorescent dye called pafolacianine (Cytalux) can help surgeons see and remove solid tumors in children and teens during surgery. The dye targets cancer cells and lights up under a special near-infrared camera. Up to 20 participants aged 6 mont…

This study tests whether a digital art therapy app called ARTCan is practical and acceptable for young adults aged 18-25 who survived childhood cancer. Participants use the app for 6 weeks to create art and complete mood surveys. The goal is to see if at least 10 out of 15 partic…

The BEPPO study is testing whether a structured exercise program can improve physical and mental health in 346 children and teens (ages 3-18) undergoing cancer treatment across 13 German centers. Participants are randomly assigned to either a 6-month exercise program (3-5 session…

This study explores whether a normal week-long camping experience can improve the psychological well-being of children with cancer. Researchers will interview children and families before, during, and after camp to measure changes in self-esteem and social interactions. Up to 5,0…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study investigates whether a personalized exercise program can improve physical performance and reduce fatigue in children and adolescents with cancer. Participants will engage in supervised and home-based training sessions during and after their cancer treatment. The goal i…

This study is testing whether a structured exercise program called 'Just Move' can help children and young adults (ages 2–25) with newly diagnosed cancer maintain physical function and improve quality of life during chemotherapy. Participants will either follow a 30-minute exerci…

This study tests an online program called eSCCIP designed to help parents and caregivers of children with cancer feel less distressed and more able to cope. The program includes web-based modules and video sessions with a coach. Researchers will compare it to a basic informationa…

This Canadian study is testing whether cannabinoid oils (CBD and THC) can safely help manage symptoms like pain in children aged 4-17 with relapsed or refractory cancer. The trial will enroll 60 kids across three hospitals, giving them different ratios of CBD to THC oils to see w…

This study tests whether a six-week at-home light therapy program is practical and helpful for childhood cancer survivors who have nerve pain or numbness from chemotherapy. Twenty survivors aged 5 and older will use a light therapy device on their symptoms for 15 minutes, three d…

This study tests whether using virtual reality before proton therapy sessions can reduce stress and improve positioning in children aged 7 to 18 with cancer. Researchers will compare positioning time and anxiety levels when kids use VR versus standard care. The goal is to find a …

This study tests a computer program called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. Participants use the tool to rate symptoms, find patterns, and plan how to cope. The goal is to see if using C-SCAT boosts their confidence and a…

This study tests whether a 12-week exercise program can improve cardiorespiratory fitness in children and teens who have finished cancer treatment. Participants, aged 7 to 23, will be randomly assigned to either the exercise program or general activity recommendations. The main g…

This study tests whether a video and a trained navigator can help parents of children with cancer better communicate their goals and values to the medical team. About 567 parents will either get the video tool or usual care. The goal is to see if this leads to more discussions ab…

This study looks at whether a three-month stay focused on adapted physical activity can improve the physical fitness and quality of life of children with chronic illnesses, rare diseases, or disabilities who have become physically deconditioned. About 50 children aged 8 to 18 wit…

This pilot study tests a behavioral program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. The program includes weekly online group sessions and daily app activities focused on coping skills, mindfulness, and peer support. Researchers wan…

This study tests whether guided imagery—a relaxation technique using calming mental pictures—can reduce nausea and vomiting caused by chemotherapy in children aged 7 to 18 with cancer. Half of the 40 participants will receive guided imagery plus standard care, while the other hal…

This study tests whether an internet-based parent-child interaction therapy (I-PCIT) can help improve behavior in children aged 2-12 who have or had cancer. Parents of 300 children will be randomly assigned to start therapy right away or wait 5-6 months. The goal is to see if the…

This study looks at whether wearing virtual reality glasses before a spinal chemotherapy procedure can lower anxiety, fear, and improve heart rate and breathing in children aged 4 to 10 with cancer. Twenty children will be split into two groups: one group uses the VR glasses, and…

This study tests whether regular massage therapy can improve sleep for children aged 12-21 who are hospitalized for cancer treatment or stem cell transplant. Seventy participants will either receive standard care or a 20-30 minute massage five days a week for three weeks. Sleep w…

This study tests whether Snoezelen, a multisensory relaxation approach using lights, sounds, and textures, can reduce anxiety in children aged 8 to 17 who are hospitalized for chemotherapy. Twenty participants will compare their symptoms during a chemo cycle with Snoezelen sessio…

This study tests if creating a short digital story about their cancer journey can reduce depressive symptoms and improve self-esteem and quality of life in Hong Kong Chinese teens who have finished cancer treatment. About 248 survivors aged 13-18 will either join four 2.5-hour wo…

This study is testing a new tool called the Cancer Care Companion, which is accessed through a patient portal. Parents of children recently diagnosed with cancer will use it for 3 months to complete educational tasks, surveys, and read patient stories. The goal is to see if the t…

This study tests a nurse-led program called Dreamcatchers to help children aged 6-12 with cancer sleep better. The program uses relaxation techniques like breathing exercises and muscle relaxation instead of sleep medications. About 68 children will take part to see if this appro…

This study tests a talk therapy called EASE for parents whose child has cancer. The goal is to see if it reduces traumatic stress symptoms over six months. About 306 parents will take part, answering questionnaires at several points. The therapy is added to usual care and compare…

This study tests an online program called PLAY for caregivers of young children who have finished cancer treatment. The program includes 7 modules and coaching sessions to help with parenting, stress, and school readiness. Researchers want to see if caregivers find it easy to use…

This study tests a dissolvable film containing ondansetron to prevent vomiting caused by radiation therapy in children aged 1-14 with cancer. The film is placed on the tongue and melts without water. Researchers will compare its effectiveness and safety against standard care in 6…

Many parents of childhood cancer survivors struggle with intense fear that their child's cancer will come back. This study tests a 7-session group therapy program, adapted from one used for adult survivors, to see if it is acceptable and helpful for parents. Thirty-six parents in…

This study tests a mobile app designed to help children aged 9 to 16 who have recently finished cancer treatment manage their symptoms. The app provides educational materials and real-time support, plus personalized help from a nurse. Researchers want to see if using the app for …

Brothers and sisters of children with cancer often face loneliness, fear, and grief, yet Swedish clinics have no standard way to measure what they need. This study translates two questionnaires into Swedish: the Sibling Cancer Needs Instrument, which asks about information, suppo…

This study is testing whether a special team of experts, including biologists, mathematicians, and doctors, can come up with new treatment ideas for children and young adults with cancer that is unlikely to be cured by standard treatments. The team will review each patient's case…

This study uses non-invasive MRI and MRS scans to measure how well muscle cells produce energy in adults who survived childhood acute lymphoblastic leukemia (ALL). Researchers will compare 60 survivors with low muscle mass to healthy volunteers. The goal is to understand why many…

This study will examine muscle health in 533 adult survivors of childhood cancer and compare them to people without a cancer history. Using advanced imaging and tests, researchers hope to identify different types of muscle problems. The goal is to better understand why survivors …

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

Researchers are building a bank of blood and saliva samples from adults who were treated for cancer as children. The goal is to study genetic factors that may affect the risk of long-term side effects from childhood cancer treatment, such as heart, brain, lung, bone, and kidney p…

This study looks at how two common chemotherapy drugs, vincristine and doxorubicin, affect bladder function and urine composition in children who have finished cancer treatment. Researchers will use simple, non-invasive tests to measure urine flow and check for bladder-related pr…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study looks at how well children with cancer are cared for at the end of life. Researchers will review medical records and talk to parents of about 1,190 children who have passed away. The goal is to understand what factors lead to better or worse care, so future families ca…

This study investigates whether a blood marker called anti-Müllerian hormone (AMH) can predict future infertility in children and adolescents who have undergone cancer treatment. Many young patients recover normal menstrual cycles or puberty after chemotherapy, but their ovarian …

This study tests whether short educational videos can help young adults who survived childhood cancer learn about and get the HPV vaccine. The researchers will enroll 55 survivors aged 18-26 who haven't finished the vaccine series. Participants will watch the videos on Facebook a…

This study collects safety and effectiveness data on cancer medicines used off-label or through compassionate access in children, adolescents, and young adults up to age 25 with pediatric malignancies. Participants are not enrolled in other treatment trials and are discussed by e…

This study looks at how well the immune system works in children who have finished cancer treatment. It aims to see if restarting vaccinations just 3 months after therapy is safe and effective. Researchers will compare giving a single booster shot versus a full series of vaccines…

This study is creating a program called CERCA to help families of children with cancer get their social needs met, like finding food, housing, or transportation. Researchers will work with families, doctors, and community groups to design the program and test if it is practical a…

This study is for children whose cancer has come back or not responded to standard treatments. Researchers will use advanced genetic testing of each child's tumor to match them with a targeted drug or drug combination. The goal is to find the safest dose and see if the treatment …

This study follows people who survived childhood cancer for at least five years to learn about the long-term effects of the disease and its treatment. Researchers send questionnaires to survivors to gather information on quality of life, physical and mental health, medication use…

Childhood cancer survivors who received certain treatments are at higher risk for heart problems. This study tests whether an online program with personalized education and motivational coaching can encourage them to get a recommended heart screening. About 350 adult survivors wi…

This study collects health information from up to 30,000 children and adults who have or had childhood cancer at St. Jude Children's Research Hospital. The goal is to track their long-term outcomes and any late side effects from treatment. No new treatments are tested—this is pur…

This study follows 10,000 childhood cancer survivors treated at St. Jude Children's Research Hospital over their entire lives. Researchers will track health problems that may appear years after cancer treatment, such as heart issues or second cancers. The goal is to learn how to …

This study is testing a new tool called HPARSS that helps doctors identify childhood cancer survivors at risk for hearing or vision problems. The tool uses a patient's past cancer treatments to flag who needs screening. Researchers will see if this approach leads to more kids get…

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study will follow 6,000 children, adolescents, and young adults with cancer in low- and middle-income countries. Researchers will collect data from medical records and questionnaires to understand why treatment failure and severe side effects are more common in these setting…

This study is creating a large research database of childhood cancer survivors treated at Children's Hospital Los Angeles. The goal is to track their long-term health, identify late effects from cancer therapy, and find ways to improve their quality of life. Up to 5,000 survivors…

This study tests whether a program called COMPRENDO, which uses trained peer navigators, can help more Hispanic children with cancer enroll in clinical trials. The navigators provide education and support to parents in English or Spanish. The study will compare enrollment rates a…

This study asks families of children with cancer to donate their child's tumor tissue after death. Researchers will use the tissue to create lab models and share samples with other scientists. The goal is to better understand pediatric cancers and develop new treatments. Up to 15…

This study looks at 500 adult survivors of childhood cancer to see if a newer type of heart ultrasound, called speckle tracking, can find heart problems earlier than the usual method. Researchers want to know if this technique can detect heart damage sooner, which could help with…

This study aims to help boys who need strong cancer treatments that could harm their ability to have children later. For those who haven't gone through puberty, doctors will freeze a small piece of testicular tissue to save stem cells. The goal is to protect future fertility and …

This study is building a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Participants will complete physical and mental function tests, surveys, and provide blood samples over time. The goal is to learn how cancer and its treatments affect agi…

This study follows 140 children who have had cancer treatment to check how their lungs are working over time. Researchers use breathing tests, lung scans, and breath samples to spot early signs of lung problems. The goal is to better understand and detect lung damage caused by ca…

This study tests a questionnaire called QUOCCAS that parents and children fill out to see if it can spot kids with a higher chance of having an inherited cancer syndrome. About 205 children and teens with cancer will take part, giving a blood or saliva sample for genetic testing.…

This study looks at how parents of children with cancer cope with stress and how that affects their child's emotional well-being. Researchers will survey 60 parents and their children (ages 8–17) being treated at pediatric cancer centers in Italy. The goal is to understand which …

This study collects real-world data on how well new cancer drugs work in children, teens, and young adults up to age 25 who have relapsed or stopped responding to treatment and cannot join a clinical trial. Researchers will track safety and effectiveness of targeted therapies, im…

This study follows 249 children and young adults with cancer who are receiving physical or neuropsychomotor therapy at hospitals across Italy. Researchers will measure changes in their ability to move and perform daily tasks over time. The goal is to understand which rehabilitati…

This research study collects blood and tissue samples from 20,000 people with suspected solid tumors. The samples are stored in a repository for scientists to study later. The goal is to advance our understanding of cancer, not to test a new treatment.

This study looks at whether a new, ultrafast whole genome sequencing test can give doctors genetic information about a child's cancer within days instead of the usual 1-4 weeks. Researchers at Cambridge University Hospitals will enroll 50 children and young adults under 25 with s…

This study follows children who had radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will compare them to children who did not have radiation, looking for risk factors and genetic clues. The goal is to create better screeni…

This study tests whether simple digital tools—like letters and text messages—can encourage adolescent and young adult survivors of childhood cancer to schedule and attend long-term follow-up appointments. About 530 participants who are overdue for care will receive different comb…

This study works with Spanish-speaking parents and doctors to create educational videos about childhood cancer. The goal is to help caregivers better understand their child's care when English is not their first language. The project will test if these videos are easy to use and …

This study looks at whether families of children with cancer are willing to join a program that provides financial support. About 40 families will be randomly assigned to either receive the PediRISE support program or standard care. The goal is to see if the program is feasible a…

This observational study aims to find blood markers that show brain injury caused by cancer treatments in children with brain tumors. Researchers will collect plasma samples from 560 children before and after surgery, during radiation or chemotherapy, and up to three years later.…

This study is creating a large database of tumor samples and health information from children and young adults with cancer. Researchers will analyze the genetic makeup of these tumors to find patterns and potential new treatments. The goal is to better understand pediatric cancer…

This study is observing 500 Indian children with acute lymphoblastic leukemia (ALL) to see how their genes influence treatment side effects and how well they respond to therapy. Researchers will track side effects and measure early response to steroids. The goal is to better unde…

This study will look back at the medical records of 18,000 children, teens, and young adults with cancer treated in five low- and middle-income countries. The goal is to measure how often treatment fails or causes serious side effects, especially for leukemia and lymphoma. No new…

This study collects and freezes testicular tissue from prepubertal boys before they start cancer treatment that has a high risk of causing infertility. The tissue is stored for potential future use to restore fertility and for research to better understand germ cell development. …

This study follows children under 21 who have a genetic condition that raises their risk of developing cancer, along with their relatives. Researchers will collect health information and samples over time to better understand how these cancers develop and how to catch them early.…

This study is creating a registry to collect information about children under 18 who are treated for cancer at participating hospitals in Africa. The goal is to track how many children have cancer, what types and stages they have, what treatments they receive, and how they do ove…

This study follows 3,000 childhood cancer survivors in Switzerland to learn about long-term health problems caused by cancer treatments. Participants undergo physical exams, lab tests, and questionnaires during regular follow-up visits. The goal is to better understand and manage…