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New hope for kids with tough cancers: precision drugs tested

NCT ID NCT06208657

Recruiting now Disease control Sponsor: Australian & New Zealand Children's Haematology/Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This trial tests whether giving children and teens with advanced solid tumors, brain tumors, or lymphomas drugs that match their tumor's genetic profile can help. About 90 participants will receive one of four drug combinations based on their tumor's molecular features. The goal is to find the right dose and see if the tumors shrink or stop growing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Paxalisib, Opdualag (nivolumab + relatlimab), irinotecan, temozolomide
What this could lead to
If successful, this could lead to more effective, personalized treatment options for children with hard-to-treat cancers.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not apply to all patients. The drugs may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

central nervous system cancer childhood malignant neoplasm childhood neoplasm lymphoma neoplasm Recurrence refractory hematologic cancer refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILDHOOD BRAIN TUMOR CHILDHOOD CANCER CHILDHOOD SOLID TUMOR RECURRENT CANCER REFRACTORY CANCER

Contacts and locations

Locations

  • BC Children's Hospital

    RECRUITING

    Vancouver, Canada

  • CHU Sainte Justine

    RECRUITING

    Montreal, Canada

  • Children's Hospital of Eastern Ontario

    NOT_YET_RECRUITING

    Ottawa, Canada

  • John Hunter Children's Hospital

    RECRUITING

    Newcastle, New South Wales, Australia

  • Monash Children's Hospital

    RECRUITING

    Melbourne, Victoria, Australia

  • Perth Children's Hospital

    RECRUITING

    Perth, Western Australia, Australia

  • Queensland Children's Hospital

    RECRUITING

    Brisbane, Queensland, Australia

  • Royal Hobart Hospital

    RECRUITING

    Hobart, Tasmania, 7000, Australia

  • Stollery Children's Hospital

    NOT_YET_RECRUITING

    Edmonton, Canada

  • Sydney Children's Hospital, Randwick

    RECRUITING

    Sydney, New South Wales, Australia

  • The Children's Hospital at Westmead

    RECRUITING

    Sydney, New South Wales, Australia

  • The Hospital for Sick Children

    RECRUITING

    Toronto, Canada

  • The Royal Children's Hospital

    RECRUITING

    Melbourne, Victoria, Australia

    Contact Email: •••••@•••••

  • Women's and Children's Hospital

    RECRUITING

    Adelaide, South Australia, Australia

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