Central nervous system disorder
MONDO:0002602A disease involving the central nervous system.
Also known as: CNS disorder, central nervous disease, central nervous system disease, central nervous system disease or disorder, central nervous system disorder, disease of central nervous system, disease of the central nervous system, disease or disorder of central nervous system
20455 clinical trials for this condition and its sub-types, 119 tagged with Central nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system disorder
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Brain disorder 137 trials · 16,709 incl. sub-types
71 sub-types
- Mental disorder 250 trials · 7,390 incl. sub-types Sub-types →
- Cerebrovascular disorder 108 trials · 3,292 incl. sub-types Sub-types →
- Basal ganglia disorder 9 trials · 1,322 incl. sub-types Sub-types →
- Brain neoplasm 247 trials · 1,080 incl. sub-types Sub-types →
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Insomnia 823 trials · 827 incl. sub-types Sub-types →
- Cerebral cortex disorder 0 trials · 723 incl. sub-types Sub-types →
- Brain injury 220 trials · 693 incl. sub-types Sub-types →
- Epilepsy 461 trials · 645 incl. sub-types Sub-types →
- Migraine disorder 393 trials · 414 incl. sub-types Sub-types →
- Cerebellar disorder 9 trials · 271 incl. sub-types Sub-types →
- Visual pathway disorder 1 trial · 201 incl. sub-types Sub-types →
- Pituitary gland disorder 18 trials · 175 incl. sub-types Sub-types →
- Thalamic disorder 0 trials · 110 incl. sub-types Sub-types →
- Intracranial hypertension 51 trials · 97 incl. sub-types Sub-types →
- Encephalitis 26 trials · 96 incl. sub-types Sub-types →
- Hydrocephalus 52 trials · 79 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Hepatic encephalopathy 45 trials Sub-types →
- Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types Sub-types →
- Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types Sub-types →
- Intracranial hypotension 32 trials
- Cluster headache syndrome 26 trials Sub-types →
- Brain edema 23 trials
- Narcolepsy without cataplexy 22 trials
- Encephalomalacia 1 trial · 13 incl. sub-types Sub-types →
- Olfactory nerve disorder 8 trials · 12 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Traumatic encephalopathy 11 trials
- Cerebral cortical dysplasia 2 trials · 7 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Akinetic mutism 3 trials
- Bilirubin encephalopathy 3 trials Sub-types →
- Central nervous system cyst 3 trials Sub-types →
- Encephaloclastic disorder 0 trials · 3 incl. sub-types Sub-types →
- Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types Sub-types →
- Megalencephaly 3 trials Sub-types →
- Cerebral malaria 2 trials
- Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types Sub-types →
- Wernicke encephalopathy 1 trial
- Brain compression 1 trial
- Carbon monoxide-induced delayed encephalopathy 1 trial
- Cerebral sarcoidosis 1 trial
- Reye syndrome 0 trials
- XK aprosencephaly 0 trials
- Acute bilirubin encephalopathy 0 trials
- Aprosencephaly 0 trials
- Atelencephaly 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autosomal recessive frontotemporal pachygyria 0 trials
- Brain malformations with or without urinary tract defects 0 trials
- Bulbar polio 0 trials
- Central nervous system origin vertigo 0 trials
- Cerebritis 0 trials
- Chronic bilirubin encephalopathy 0 trials
- Colpocephaly 0 trials
- Complex cortical dysplasia with other brain malformations 0 trials Sub-types →
- Corpus callosum agenesis of blepharophimosis robin type 0 trials
- Corpus callosum dysgenesis X-linked recessive 0 trials
- Corpus callosum dysgenesis cleft spasm 0 trials
- Corpus callosum dysgenesis hypopituitarism 0 trials
- Diabetic encephalopathy 0 trials
- Disorder of optic chiasm 0 trials
- Encephalopathy due to mitochondrial and peroxisomal fission defect 0 trials Sub-types →
- Encephalopathy, acute transient 0 trials
- Encephalopathy, recurrent, of childhood 0 trials
- Glycine encephalopathy 0 trials Sub-types →
- Hypothalamic hamartomas with gelastic seizures 0 trials
- Meningoencephalocele 0 trials
- Midbrain disorder 0 trials
- Occipital pachygyria and polymicrogyria 0 trials
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Neurodegenerative disease 187 trials · 3,289 incl. sub-types
22 sub-types
- Tauopathy 24 trials · 1,193 incl. sub-types Sub-types →
- Demyelinating disease 27 trials · 938 incl. sub-types Sub-types →
- Inherited neurodegenerative disorder 11 trials · 808 incl. sub-types Sub-types →
- Motor neuron disorder 70 trials · 510 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Primary progressive aphasia 42 trials · 71 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Neuroaxonal dystrophy 1 trial · 9 incl. sub-types Sub-types →
- Secondary Parkinson disease 9 trials Sub-types →
- Primary progressive apraxia of speech 2 trials
- Marchiafava-Bignami disease 1 trial
- Human prion disease 1 trial Sub-types →
- Brachial amyotrophic diplegia 0 trials
- Choroidal sclerosis 0 trials Sub-types →
- Eyelid degenerative disorder 0 trials
- Hypertrophic olivary degeneration 0 trials
- Infantile bilateral striatal necrosis 0 trials Sub-types →
- Olivopontocerebellar atrophy 0 trials
- Primary progressive freezing gait 0 trials
- Senile degeneration of brain 0 trials
- Superficial siderosis 0 trials
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Central nervous system neoplasm 51 trials · 1,986 incl. sub-types
10 sub-types
- Central nervous system cancer 131 trials · 1,706 incl. sub-types Sub-types →
- Brain neoplasm 247 trials · 1,080 incl. sub-types Sub-types →
- Tumor of meninges 1 trial · 123 incl. sub-types Sub-types →
- Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types Sub-types →
- Central nervous system germ cell tumor 6 trials · 9 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
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Spinal cord disorder 47 trials · 1,255 incl. sub-types
10 sub-types
- Spinal cord injury 650 trials
- Anterior horn disorder 0 trials · 485 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Spina bifida 44 trials · 59 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Syringomyelia 6 trials Sub-types →
- Tethered spinal cord syndrome 6 trials
- Radiation myelitis 0 trials
- Segmental spinal dysgenesis 0 trials
- Vascular myelopathy 0 trials
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Autoimmune disorder of central nervous system 2 trials · 881 incl. sub-types
8 sub-types
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Central nervous system lupus 3 trials
- Autoimmune epilepsy 1 trial
- Miller Fisher syndrome 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autoimmune optic neuritis 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Palsy 36 trials · 846 incl. sub-types
10 sub-types
- Cerebral palsy 443 trials · 499 incl. sub-types Sub-types →
- Hemiplegia 176 trials · 179 incl. sub-types Sub-types →
- Quadriplegia 73 trials
- Paraplegia 47 trials · 68 incl. sub-types Sub-types →
- Facial paralysis 19 trials · 34 incl. sub-types Sub-types →
- Respiratory paralysis 20 trials
- Erb palsy 11 trials
- Ophthalmoplegia 0 trials · 11 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Klumpke's paralysis 0 trials
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Encephalomyelitis 3 trials · 227 incl. sub-types
7 sub-types
- Encephalitis 26 trials · 96 incl. sub-types Sub-types →
- Meningitis 42 trials · 73 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Hypophysitis 2 trials Sub-types →
- Venezuelan equine encephalitis 1 trial
- Cerebritis 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Central nervous system infectious disorder 10 trials · 163 incl. sub-types
12 sub-types
- Viral infection of central nervous system 3 trials · 58 incl. sub-types Sub-types →
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Infectious meningitis 3 trials · 49 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Central nervous system tuberculosis 1 trial · 7 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Intracranial abscess 3 trials
- Cerebral malaria 2 trials
- Congenital toxoplasmosis 2 trials
- Human prion disease 1 trial Sub-types →
- Subdural empyema 1 trial
- Neuroschistosomiasis 0 trials
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Optic nerve disorder 23 trials · 96 incl. sub-types
8 sub-types
- Optic atrophy 4 trials · 26 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Low tension glaucoma 21 trials
- Anterior ischemic optic neuropathy 9 trials · 11 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Optic disk drusen 1 trial
- Extensive peripapillary myelinated nerve fibers 0 trials
- Isolated optic nerve aplasia 0 trials
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Tinnitus 91 trials
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Central nervous system vasculitis 3 trials · 55 incl. sub-types
5 sub-types
- Temporal arteritis 52 trials Sub-types →
- Primary central nervous system vasculitis 2 trials Sub-types →
- Benign angiitis of the central nervous system 0 trials
- Central nervous system AIDS arteritis 0 trials
- Cerebral arteritis 0 trials
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Trigeminal neuralgia 37 trials
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Cerebrospinal fluid leak 16 trials · 17 incl. sub-types
1 sub-type
- Cerebrospinal fluid rhinorrhea 2 trials
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High pressure neurological syndrome 0 trials · 5 incl. sub-types
1 sub-type
- Decompression sickness 5 trials
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SPAST-related motor disorder 0 trials · 2 incl. sub-types
1 sub-type
- Hereditary spastic paraplegia 4 2 trials
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1 sub-type
- NDE1-related microhydranencephaly 0 trials
Most studied deeper sub-types
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Can a new drug curb seizures in children with severe epilepsy?
Disease control CompletedResearchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Magnetic pulses may restore arm function in chronic stroke survivors
Disease control CompletedThis pilot study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can improve arm and hand movement in people who had a stroke more than six months ago. The study enrolls 7 adults aged 18-80 with stable uppe…
Sponsor: Magnetic Tides • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New drug targets brain inflammation to slow Alzheimer's
Disease control CompletedThis study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…
Phase 2 • Sponsor: Inmune Bio, Inc. • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New device aims to pull clots from the brain in major strokes
Disease control CompletedThis completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …
Sponsor: Gravity Medical Technology, INC • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Friends and family may be key to preventing second strokes
Disease control CompletedThis study tested whether using social networks (like family and friends) can help people at high risk for stroke stick to their medications and control risk factors after leaving the hospital. Researchers enrolled 720 patients and compared standard care with a social network-bas…
Sponsor: Changhai Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New Parkinson's drug shows promise in Year-Long trial
Disease control CompletedThis study tested the safety and effectiveness of tavapadon, an experimental drug, in 992 people with Parkinson's disease over 58 weeks. Participants took flexible doses of the medication to see how well it controlled symptoms and what side effects occurred. The goal was to under…
Phase 3 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New drug tavapadon tested to ease Parkinson's symptoms
Disease control CompletedThis Phase 3 trial tested whether tavapadon, a daily pill, can improve movement and daily activities in people with early Parkinson's disease. Over 300 participants took either tavapadon or a placebo for 27 weeks. The study measured changes in motor function and daily living skil…
Phase 3 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Could a russian drug boost brain function in chronic ischemia?
Disease control CompletedThis study tested whether the drug Mexidol (given first as injections, then as pills) can improve thinking and memory in people with chronic cerebral ischemia, a condition where the brain doesn't get enough blood flow. 318 adults aged 40-90 with mild to moderate cognitive impairm…
Phase 3 • Sponsor: Pharmasoft • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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New Parkinson's drug HER-096 passes first safety check in small trial
Disease control CompletedThis early-stage trial tested the safety of a new drug called HER-096 for Parkinson's disease. It involved 32 people: healthy volunteers who got a single dose, and Parkinson's patients who received multiple doses over four weeks. The main goal was to check for side effects and ho…
Phase 1 • Sponsor: Herantis Pharma Plc. • Aim: Disease control
Last updated Jun 26, 2026 16:31 UTC
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New MRI technique could sharpen detection of active MS lesions
Diagnosis CompletedThis study tested two different MRI sequences to see which one better detects active inflammatory lesions in the brains of people with multiple sclerosis (MS). 180 adults with known central nervous system inflammatory disease who needed an MRI after a recent clinical event took p…
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC
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Safer MRI scans for infants? new contrast agent studied in toddlers
Diagnosis CompletedThis study tested a contrast agent called gadopiclenol in 36 infants under 2 years old who needed an MRI. The goal was to see how the drug behaves in their bodies and check for safety. The children received a single injection before their MRI, and researchers measured drug levels…
Phase 2 • Sponsor: Guerbet • Aim: Diagnosis
Last updated Jun 27, 2026 07:55 UTC
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Could a lifestyle makeover keep your brain sharp?
Prevention CompletedThis trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …
Sponsor: National University of Singapore • Aim: Prevention
Last updated Aug 12, 2026 00:00 UTC
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Spinal injury patients may keep stronger bones with simple infusion
Prevention CompletedThis study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…
Phase 2 • Sponsor: Northwestern University • Aim: Prevention
Last updated Jun 27, 2026 08:01 UTC
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Can a daily tablet quiet the seizures of two devastating genetic disorders?
Symptom relief CompletedResearchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …
Phase 2 • Sponsor: Takeda • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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New pill aims to quiet Schizophrenia's worst symptoms
Symptom relief CompletedThis study tests an experimental oral medication, ML-007C-MA, in 307 adults hospitalized with schizophrenia who are having a sudden worsening of psychosis. The goal is to see if the drug reduces symptoms like hallucinations and delusions better than a placebo. Participants take t…
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Symptom relief
Last updated Jul 11, 2026 00:00 UTC
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New drug shows promise in taming tardive dyskinesia movements
Symptom relief CompletedThis study tested a drug called SD-809 (deutetrabenazine) in 298 people with moderate to severe tardive dyskinesia, a condition causing uncontrollable movements. Participants received either the drug or a placebo for 12 weeks. The main goal was to see if the drug reduced the seve…
Phase 3 • Sponsor: Auspex Pharmaceuticals, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Parkinson's patients try antioxidant supplements to boost brain health
Symptom relief CompletedThis study looked at whether nutritional supplements, specifically N-acetyl cysteine (NAC) given orally and intravenously, could support brain function in people with Parkinson's disease. The researchers measured dopamine activity and markers of inflammation in the brain using sp…
Sponsor: Thomas Jefferson University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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New migraine pill under the tongue shows promise in early trial
Symptom relief CompletedThis completed Phase 2a trial tested whether a sublingual tablet called MTX101 can safely relieve migraine pain in adults. 78 participants took either the drug or a placebo during a migraine attack and tracked their symptoms. The study measured pain reduction and the need for res…
Phase 2 • Sponsor: Manistee Therapeutics • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Insomnia pill meets antidepressant: safety check underway
Knowledge-focused CompletedThis study examines whether a new insomnia drug, YZJ-1139, can be safely taken with the antidepressant escitalopram. Healthy adults aged 18 to 45 will receive both drugs and be monitored for side effects, drug levels in the blood, and changes in eye movements, balance, and thinki…
Phase 1 • Sponsor: Shanghai Haiyan Pharmaceutical Technology Co., Ltd. • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Scientists probe hidden memory system that might survive brain damage
Knowledge-focused CompletedThis completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New pill formulation tested for better absorption in healthy volunteers
Knowledge-focused CompletedThis study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.
Phase 1 • Sponsor: NeuroPro Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Brain drain device registry completed – no major surprises
Knowledge-focused CompletedThis completed registry followed 120 patients who received an Integra external ventricular drainage (EVD) system to drain excess fluid from the brain. The goal was to check how well the device performed and how safe it was in real-world use. Researchers measured whether the drain…
Sponsor: Integra LifeSciences Corporation • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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New radiation technique for brain tumors under the microscope
Knowledge-focused CompletedThis completed study gathered information from nearly 1,000 patients who received or were scheduled to receive HyperArc stereotactic radiosurgery, a precise radiation treatment for brain tumors. The goal was to collect data on survival and tumor control to compare HyperArc with o…
Sponsor: Varian, a Siemens Healthineers Company • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC