Cardiac ventricle disorder

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This study tested a new device called the ACURATE neo2, which replaces a narrowed heart valve without open-heart surgery. About 1,900 people with severe aortic stenosis received either the new device or a standard one. The goal was to see if the new device is safe and works as we…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Doctors usually wait until symptoms appear before replacing the valve, but by then the heart may already be damaged. The researchers use MRI scans to find hidden scarring …

This phase 3 trial tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a narrowing of the heart's aortic valve that currently has no drug treatment. The study enrolls 150 people with moderate, symptom-free valve disease. Particip…

This trial compares two different TAVI devices (Evolut FX and Sapien 3 Ultra Resilia) used to replace a narrowed heart valve in people with aortic stenosis. About 1,346 patients will be randomly assigned to get one device or the other. Researchers will track deaths, strokes, valv…

This study looks at people with severe aortic stenosis who need a new heart valve (TAVI). Normally, doctors do a coronary angiogram first to check for blocked arteries. But this test can cause kidney damage or bleeding, especially in older patients. The trial will compare the usu…

This study compares two procedures for severe aortic valve stenosis: transcatheter aortic valve implantation (TAVI), a less invasive approach, and standard open-heart surgery. It will follow 4,000 high-risk patients for up to 24 months to see which method leads to fewer deaths, h…

This study is testing a new device called the Hydra Transcatheter Aortic Valve System in 500 people with severe aortic stenosis, a condition where the heart's aortic valve becomes narrow. The device is implanted through a catheter, avoiding open-heart surgery. Researchers will tr…

This study follows 250 people with severe aortic stenosis who receive the SAPIEN 3 transcatheter heart valve as part of their standard care. The goal is to see how safe and effective the valve is over the long term in everyday clinical practice. Researchers will track how many pa…

This trial compares two types of transcatheter heart valves—one designed to sit above the natural valve opening (supra-annular) and one that sits within it (annular)—in people with severe aortic stenosis and a small aortic annulus (≤23 mm). The goal is to see which valve leads to…

This study is testing a new heart valve called ACURATE neo2 in 51 patients with severe aortic stenosis, a condition where the heart's main valve is narrowed. The valve is placed using a tube through an artery, avoiding open-heart surgery. Researchers are tracking how many patient…

This study is testing a new heart valve device (JenaValve Trilogy) placed through a tube in an artery, without open surgery. It is for 50 adults who have a mechanical heart pump (LVAD) and also a leaky aortic valve that makes the pump work less effectively. The goal is to see if …

This study tests a next-generation heart valve (Navitor) in 333 people with severe aortic stenosis who are too high-risk for open-heart surgery. The goal is to see if the valve is safe and works well at 30 days, focusing on survival and reducing leaks around the valve. The valve …

This study looks at whether people with an On-X mechanical aortic heart valve can safely take a lower dose of the blood thinner warfarin. The goal is to reduce bleeding complications while still preventing dangerous blood clots. Researchers will follow 510 adults for up to 5 year…

This study looks at whether giving an extra balloon inflation after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will be randomly assigned to receive this extra step or not. The goal is to see if i…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests a new device called the DurAVR™ THV System, a replacement heart valve placed through a small tube in an artery, for people with severe aortic stenosis (a narrowed heart valve). The trial involves 150 participants and aims to see if the device is safe and works we…

This early study tests a new device called the DurAVR™ heart valve in 15 people aged 65 and older with severe aortic stenosis, a condition where the heart's aortic valve becomes narrowed. The valve is implanted through a catheter (TAVR) without open-heart surgery. The main goals …

This large study compared two treatments for severe aortic stenosis (a narrowed heart valve) in 1,746 patients at intermediate risk for surgery. One group got a less invasive procedure called TAVI (a new valve inserted through a tube in the artery), and the other had open-heart s…

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This study compares a new, less invasive shockwave device to standard surgery for treating severe calcium buildup in the main leg artery. The shockwave uses sound waves to break up the calcium, while surgery involves physically removing the blockage. Researchers want to see if th…

This study compares two types of TAVR devices (self-expanding vs. balloon-expandable) in over 1,100 people with severe aortic stenosis and a small aortic annulus. The goal is to see which device leads to fewer deaths, strokes, or hospitalizations, and which performs better over t…

This study tests whether a less invasive heart valve replacement (TAVR) is safe and effective for people with moderate aortic stenosis, a condition where the heart's aortic valve is partially blocked. About 650 participants will receive the TAVR device and be monitored for compli…

This study compares two ways to replace a narrowed heart valve in people with severe aortic stenosis who are at intermediate risk for surgery. About 1,400 participants will be randomly assigned to get either a less invasive TAVI procedure or open-heart surgery (SAVR). The main go…

This study tests whether a less invasive procedure called TAVR (replacing the aortic valve through a tube in an artery) is as safe and effective as open-heart surgery for people with severe aortic stenosis who are otherwise healthy enough for surgery. About 2,200 participants wil…

This study is testing a less invasive procedure called TAVR to replace the aortic valve in 150 people who have a bicuspid aortic valve (a valve with two flaps instead of three) and severe narrowing. The goal is to see if it is safe and works well for people who are at low risk fo…

This study is testing a new surgical heart valve (Model 400) in over 1,300 people with aortic valve disease. The valve is designed to replace the damaged aortic valve and improve blood flow. Researchers are checking how safe the valve is and how well it works over one year, looki…

This study looks at how safe and effective the Avalus Ultra artificial heart valve is for people with aortic valve disease. About 190 participants will be followed for one year after surgery to check for problems like blood clots or valve failure, and to see how well the valve wo…

This study is testing a newer version of a heart valve device, called the SAPIEN 3 Ultra, in 200 people with severe aortic stenosis (a narrowed heart valve). The valve is implanted through a tube in an artery, avoiding open-heart surgery. Researchers are checking how well the val…

This study is testing a small mechanical heart valve (15mm) in 20 children who need their aortic valve replaced due to disease or damage. The valve is designed to last and is monitored for safety and function over 5 years. Children will need lifelong blood-thinning medication to …

This study tests a new heart valve called the NAVITOR, placed using a thin tube (catheter) without open-heart surgery. It includes 434 people with severe aortic stenosis who are at intermediate or low risk for surgery. The main goals are to check for leaks around the valve at 30 …

This early study is testing a new balloon-expandable heart valve device (TAVI) in 8 people with severe aortic stenosis who are at increased surgical risk. The goal is to see if the device can be safely delivered and perform as intended. Because this is a first-in-human study with…

This study compares two types of TAVI valves (Edwards and CoreValve Evolut) in 102 people with small, failing surgical aortic valves. The goal is to see which valve leads to fewer problems like high pressure or leakage after the procedure. Results could guide doctors in choosing …

This study compares two ways to replace a narrowed heart valve in elderly patients (65+) who have a small valve opening. One method is less invasive (TAVR, through a tube in an artery), the other is open-heart surgery. The goal is to see which approach gives better blood flow and…

This study follows 255 Chinese patients who received the INSPIRIS RESILIA aortic valve to see how safe and well it works over several years. Researchers track problems like valve failure, blood clots, bleeding, and the need for another surgery. The goal is to confirm the valve's …

This study is testing a new device called the ALLEGRA Plus Transcatheter Heart Valve in 177 people with severe aortic stenosis or a failed surgical valve. The valve is implanted through a catheter, avoiding open-heart surgery. Researchers are checking how safe and effective it is…

This study compares two newer self-expanding heart valves and a minimalist approach (using only local anesthesia, avoiding extra tubes) against standard care for people with severe aortic valve stenosis. About 836 participants will be randomly assigned to receive either the new v…

This study tests whether using 3D simulation before a minimally invasive aortic valve replacement helps doctors place the valve more accurately. It involves 354 adults aged 65 and older with severe aortic regurgitation (a leaky heart valve). Participants are randomly assigned to …

This study tests a special plug device to close leaks that can form around surgically implanted heart valves. These leaks can cause serious problems like heart failure or anemia. The procedure is done through a catheter, avoiding the need for another open-heart surgery. The study…

This early study is testing a new balloon-expandable heart valve system from Abbott for people with severe, symptomatic aortic stenosis. The valve is delivered through a catheter, avoiding open-heart surgery. Only 11 participants are enrolled to check if the device is safe and wo…

This study tests a new, less invasive heart valve (SAPIEN 3) for people with severe aortic stenosis who are at low risk for standard surgery. About 1,000 participants will be randomly assigned to get the new valve or traditional open-heart surgery. The goal is to see if the new v…

This study was designed to test the safety of a device called Valvosoft, which uses ultrasound waves from outside the body to treat moderate aortic valve stenosis. The goal was to see if it could improve valve movement without major complications. However, the trial was withdrawn…

This trial compares two types of replacement heart valves used in a procedure called TAVI for people with a narrowed aortic valve. One valve expands with a balloon, the other expands on its own. The study will track about 1,960 patients to see which valve leads to fewer deaths or…

This study is testing a new device called the Siegel TAVR system to replace a narrowed heart valve in 30 adults aged 50 and older with severe aortic stenosis. The goal is to see if the device can be safely implanted and improve blood flow without major complications. Participants…

This study tests a new heart valve device, the Medtronic CoreValve Evolut PRO, in 52 Chinese patients with severe aortic stenosis who are at high risk for open-heart surgery. The device is inserted through a catheter, avoiding major surgery. Researchers are checking how safe and …

This study looks at how well the ALLEGRA TAVI system works in real-world patients with severe aortic valve disease who are at high risk for surgery. Researchers tracked 346 patients to see if the device improves survival and quality of life. The goal is to control the disease and…

This study is testing a new device called the CENTERA THV, which is a replacement heart valve that can be placed without open-heart surgery. It is for people with severe aortic stenosis (a narrowed heart valve) who are at intermediate risk for surgery. The study will monitor safe…

This study was designed to test a device called Leaflex Performer for people with severe aortic stenosis, a condition where the heart's aortic valve becomes narrow. The goal was to see if the device could safely improve valve function without needing surgery or a new valve. Howev…

This study tests whether icosapent ethyl, a purified fish-oil medication, can slow the buildup of calcium in the aortic valve. About 110 adults with mild-to-moderate aortic valve stenosis will take the drug or a placebo. The main goal is to see if the drug reduces the increase in…

This study compares two ways to replace a narrowed heart valve in people with a bicuspid aortic valve (a common birth defect). One method is transcatheter aortic valve replacement (TAVR), a less invasive procedure using a tube inserted through a blood vessel. The other is traditi…

Researchers test whether an AI algorithm called AK-AVS can spot moderate-to-severe aortic stenosis, a narrowing of the heart's aortic valve, in older adults who have not been diagnosed. The study reviews about 4,000 routine electrocardiograms (ECGs) already collected during prima…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This pilot study tests whether a smartphone app, using its built-in microphone and machine learning, can detect severe aortic stenosis – a common but serious heart valve issue. Researchers will record heart sounds from 100 adults (with and without the condition) and compare the a…

This study tests whether artificial intelligence (AI) can spot a serious heart valve condition called aortic stenosis using portable, non-invasive devices. Researchers will enroll 410 adults aged 70 and older during routine primary care visits. The goal is to see if AI-powered an…

This study tests a special robotic bed called LOLE.K to see if it helps people recover faster after heart valve surgery. Twenty patients aged 60 to 85 will use the bed for early rehabilitation. Researchers will measure how long they stay in the hospital, how quickly they get off …

This study follows 200 adults in Western Denmark who are having a transcatheter aortic valve implantation, a procedure to replace a narrowed heart valve. Researchers will measure quality of life before the procedure and at follow-up using a standard questionnaire. They will also …

This study follows 50 people who previously received an INSPIRIS RESILIA aortic valve and now need a valve-in-valve procedure because their original valve is not working well. Researchers will track complications like death, stroke, bleeding, and valve movement, as well as how we…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…

This study looks at how a common heart valve procedure called TAVI changes the gut microbiome in older adults with aortic stenosis. Researchers will collect blood and stool samples before and three months after TAVI to measure bacterial byproducts and diversity. The goal is to se…

This study will enroll 210 adults aged 65 and older with early aortic stenosis (a heart valve narrowing) to see if an artificial intelligence tool can better predict how fast the disease worsens. Participants will have standard echocardiograms, and researchers will compare the AI…

This study tests whether adding automatic reminders to echocardiogram (heart ultrasound) reports can increase the number of patients with heart valve disease who see a cardiologist within six months. Researchers will randomly assign 300 patients' reports to receive no prompt, a p…

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This study looks at how certain blood components and heart imaging patterns might help predict the worsening of aortic stenosis, a common heart valve condition in older adults. Researchers will study 65 people with mild or moderate aortic stenosis and compare them to healthy cont…

This study looks at whether a heart valve replacement procedure called TAVI can be safely performed in hospitals that do not have on-site cardiac surgery backup. It involves 657 patients with severe aortic stenosis who are at high risk for surgery. The same experienced doctors pe…

This study is looking for the genetic causes of bicuspid aortic valve disease, a common heart condition where the aortic valve has two flaps instead of three. Researchers will analyze DNA from 11,000 participants, including patients and their relatives, to find gene changes linke…

This study gathers genetic and health information from over 6,400 people with bicuspid aortic valve, a common heart defect. Researchers aim to find the genes responsible for the condition and why some patients later develop serious aortic disease. No treatment is given; the goal …

This study follows 200 people who had a heart valve replacement (TAVI) to see how often they experience heart rhythm problems in the weeks after the procedure. Participants wear a portable ECG monitor for up to 4 weeks after leaving the hospital. The goal is to learn how common t…

This study tests whether wearing a portable heart monitor for up to three months before a TAVI procedure can detect silent arrhythmias in people with severe aortic stenosis. The goal is to see if catching these hidden rhythm issues early can lead to treatments that improve outcom…

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study follows 1000 patients who had a standard aortic valve replacement (TAVR) to see how their heart rhythms change over a year. Researchers will track abnormal heartbeats using ECG monitors. The goal is to learn which patients are at risk for rhythm problems and how they r…

This study is a registry that tracks 900 people with aortic valve stenosis who had either a surgical aortic valve replacement (SAVR) or a transcatheter aortic valve replacement (TAVR). The goal is to compare how safe and effective these two procedures are over time. Researchers a…

This study followed 900 adults who had their aortic valve replaced to see how safe and effective the procedure is in routine care. Researchers tracked deaths from any cause and heart-related deaths. The goal is to understand real-world outcomes beyond controlled trials.

This study looks at 364 people with mild to moderate aortic valve narrowing (aortic stenosis) to see if those with high levels of lipoprotein(a) — a type of fat in the blood — have faster disease progression than those with low levels. Participants are observed over time using he…

This study was designed to measure levels of a protein called SGLT2 in heart muscle samples taken during valve replacement surgery in people with aortic stenosis. Researchers wanted to compare SGLT2 levels between those with and without diastolic heart failure to better understan…

This study looks at whether people who get a new heart valve through a tube in their leg (TAVI) can safely go home just 24 hours later. Researchers will track 585 patients for complications like stroke, heart attack, or need for a pacemaker. The goal is to see if early discharge …

This study enrolls 800 people with severe aortic stenosis who are scheduled for a TAVI procedure (a less invasive heart valve replacement). Researchers will compare participants from different countries using CT scans of the heart and blood tests to measure inflammation. The goal…

This study looks at how well two types of replacement heart valves (balloon-expandable vs. self-expanding) work in Asian patients with a naturally small aortic valve opening. Researchers will track 31 people for one year to see which valve type leads to fewer complications and be…