Allergic disease

This study tests an experimental drug called CGT9486 (bezuclastinib) in people with advanced systemic mastocytosis, a rare and serious blood disorder. The drug aims to control the disease by blocking a key protein that drives abnormal mast cell growth. About 140 adults with aggre…

This study tests if omalizumab (Xolair), an allergy drug, can reduce serious flare-ups in people with COPD who also have allergies. About 334 participants will receive injections of the drug or a placebo for 12 months. The goal is to see if the drug lowers the number of COPD exac…

This program provides compassionate use of dupilumab (Dupixent) for patients with severe type 2 inflammatory disorders who have no other treatment options. It aims to offer access to this drug outside of a clinical trial. The program is already approved for marketing.

This study tests a new drug, BBD-1, against standard steroids for IgA vasculitis, a disease that causes purple spots on the skin, joint pain, and can damage the kidneys. The trial will enroll 30 adults with confirmed IgA vasculitis. The goal is to see if BBD-1 can clear skin spot…

This study tests whether a simple, standardized, and repeated message from healthcare professionals can improve how well patients with chronic diseases follow their treatment plans. About 1,200 adults with chronic conditions will receive this message during regular consultations.…

This study tests whether eating small, increasing amounts of raw apple can reduce mouth allergy symptoms in people who are allergic to both birch pollen and apples. 110 participants will eat either real apple or a placebo over 9 months. The goal is to see if they can tolerate a l…

This study tests a new drug called lesigercept in 150 adults with chronic spontaneous urticaria (hives lasting 6+ months) that aren't controlled by standard antihistamines. Participants receive either lesigercept or a placebo injection. The main goal is to see if lesigercept redu…

This study tests whether a new digital spacer (Whizz) helps children aged 5-16 with asthma use their inhaler correctly and stick to their medication, compared to a standard spacer. Researchers will also look for biomarkers in blood and breath to improve diagnosis and understand h…

This study tests whether adding soluble fiber (inulin) to the diet can improve asthma control in children aged 6 to 17. Participants will take a fiber or placebo drink for several weeks. Researchers will check asthma symptoms and analyze gut and nasal microbes to see if diet chan…

This study is testing an upgraded amino acid-based nutritional supplement for 30 children and adults who have severe gut problems like inflammatory bowel disease, short bowel syndrome, or severe allergies. Participants will use the supplement as part of their diet for 28 days. Re…

This study compares two ways of giving oral immunotherapy to children aged 6–16 with milk or egg allergy. One method uses daily increasing doses over a week ('rush'), while the other uses doses every two weeks ('conventional'). The goal is to see which is safer and more effective…

This study tests if higher doses of omalizumab (Xolair) can help people with food allergies tolerate more of their trigger foods. Thirty participants with allergies to peanut, cashew, walnut, egg, or milk will receive either 5 mg/kg or 15 mg/kg of omalizumab for 16 weeks. The goa…

This study tests a short, scripted conversation between doctors and Black adults with uncontrolled asthma. The goal is to help patients and doctors make decisions together about asthma medicines. Researchers will enroll 400 adults at community health centers to see if this approa…

This study is testing an allergy immunotherapy called Beltaven for people allergic to bee or wasp stings. Researchers want to see if a 3-week series of shots helps patients tolerate stings without a severe reaction. The study will follow 27 participants aged 14 and older who have…

This study will check if measuring IgE antibodies to two shrimp proteins (tropomyosin and hemocyanin) in the blood can accurately diagnose shrimp allergy in children. About 129 kids with suspected shrimp allergy will take part. They will have a food challenge, skin test, and bloo…

Nonalcoholic fatty liver disease affects many people with obesity or type 2 diabetes, and its more serious form, nonalcoholic steatohepatitis, can lead to cirrhosis and liver failure. Doctors currently rely on liver biopsy to judge how severe the disease is, but that test is inva…

This study tests whether specially modified pork (alpha-gal knockout) causes fewer allergic reactions than regular pork in people with alpha-gal syndrome. Each of the 160 participants will eat both types of pork on different days to see which one is safer for diagnosis. The goal …

This study looks for better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will test 300 adults with a history of possible allergic reactions using skin tests and controlled drug challenges. The goal i…

This study evaluates a rapid diagnostic test that can detect Candida auris, a drug-resistant fungus, in about 15 minutes. Researchers will compare the test's accuracy against standard lab methods using samples from 554 patients. The goal is to help hospitals quickly identify and …

This study is testing a new blood test called the T-cell activation test to see if it can more accurately diagnose amoxicillin allergy. Researchers will compare results from 300 people with suspected allergy and those without. If the test works well, it could replace less reliabl…

This study investigates whether a mother's consumption or avoidance of peanut and egg during pregnancy and breastfeeding influences her baby's risk of developing allergies to these foods. Pregnant women are assigned to either eat or avoid peanut and egg from 27 weeks of pregnancy…

This study tests whether a daily probiotic supplement (Bifidobacterium lactis XLTG11) can lower the chance of allergies in healthy infants under 3 years old who are at higher risk. Over 180 days, researchers will track allergy symptoms and analyze gut bacteria changes. The goal i…

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study is testing whether taking a higher dose of vitamin D during pregnancy can prevent asthma and persistent wheezing in children up to age 3. Researchers will give 2000 pregnant women either vitamin D or a placebo daily from week 22-26 of pregnancy until one week after del…

This early-stage trial tests an experimental RNA immunotherapy called ITI-9001 in adults with Japanese cedar pollen allergy. The treatment aims to retrain the immune system to reduce allergic reactions. Researchers are primarily checking safety and how well people tolerate the sh…

Researchers at Minia University are comparing two in-office tooth bleaching systems: one that uses peroxide and one that does not. Fifty adults aged 18 to 45 with healthy front teeth will receive one of the two treatments. Over six months, the team will measure how white the teet…

This study tests if inhaled epinephrine can quickly ease systemic allergic reactions that happen during allergy testing or treatment. About 100 people aged 12 and older with known allergies will take part. The goal is to see how fast symptoms improve, aiming for a safer and easie…

This study tests whether child life services—special support to help kids cope with medical procedures—can reduce pain and fear during skin prick allergy tests. About 140 children aged 1-18 will either receive this extra support or standard care. Researchers will measure pain, ho…

This study looks at the safety of a nasal spray called neffy compared to a standard epinephrine shot for treating allergic reactions. It involves 600 people aged 4 and older who have an allergic reaction during a food challenge or allergy shot session. The goal is to see if the s…

This study tests whether a diet low in saturated fats and rich in whole grains, fruits, and vegetables can reduce the severity of atopic dermatitis (eczema) in young adults. Researchers will track changes in skin symptoms and barrier function over two months. The goal is to see i…

This study tracks how adults with grass pollen allergy use Grassmuno® in everyday medical practice. Researchers will monitor treatment adherence and injection schedules over two years. The goal is to understand how well patients stick with the therapy and how it controls their sy…

This study compares two computer-assisted anesthesia methods—intraosseous and infiltration—to see which works better for children aged 6-12 with Molar-Incisor Hypomineralization (MIH), a condition causing sensitive teeth. Researchers will measure pain, stress, and heart rate in 3…

This study tests whether eating a diet very low in polyamines (natural compounds found in many foods) for a week before and after major abdominal surgery can lower pain levels. Researchers will compare pain scores and painkiller use in 278 adults who either follow the special die…

This study looks at whether using a tooth-whitening gel in one long session or several short sessions changes how much tooth pain people feel and how white their teeth get. About 60 adults with darker teeth will receive one of two common whitening gels. Researchers will measure p…

This study follows 500 adults in France who have either a genetic defect or autoantibodies that weaken their type I interferon immune response. Researchers will collect blood samples and health data over 1 to 4 years to track infections, autoimmune diseases, and cancers. The goal…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study looks at how common chemicals in personal care products, processed foods, and synthetic materials affect skin, gut, and airway health. One hundred twenty healthy adults will stay in a controlled hospital room for two 7-day periods—one with filtered air and pure product…

This study aims to find biomarkers—signs in the body—that can tell if a child will have an allergic reaction to peanut during a feeding test. It will involve 500 children aged 1 to 17 who are suspected of having a peanut allergy. No treatment is given; the goal is to better under…

This study creates a registry of people with asthma who live in urban areas, including children and adults. The goal is to gather detailed information about their asthma and allergy characteristics. This database will serve as a pool of potential participants for future research …

This study aims to find new markers in the blood that appear during non-allergic drug infusion reactions. Healthy adults will receive the antibiotic vancomycin and have blood samples taken to measure drug levels and other substances. The goal is to better understand and predict t…

This study explores whether the color of a 'cheese molar' — a tooth with a chalky white or yellow-brown spot — can predict how sensitive it is to air or touch. Researchers will photograph and scan the affected molars of children aged 5 to 8, then test sensitivity with a gentle ai…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study is testing a new, low-dose food challenge given over several days to diagnose FPIES, a food allergy that causes vomiting and diarrhea. Researchers want to find the safest dose that can still trigger symptoms in people with FPIES. The study involves 72 people aged 1 to …

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study is looking for 530 adults with hay fever in South-Eastern Australia to help create a tool that predicts thunderstorm asthma. Participants will have allergy and lung function tests, then track their symptoms during spring for two years. The goal is to find warning signs…

This study looks at whether private practice doctors can safely give children with suspected mild delayed allergies to beta-lactam antibiotics (like amoxicillin) a direct oral challenge. The challenge involves giving the child a small dose of the antibiotic and watching for a rea…

This study looks at immune cells in the lymph nodes of 16 cat-allergic adults. Half are on long-term allergy shots (immunotherapy), half are not. Researchers will give a small cat allergen injection and then sample lymph nodes and blood to see how many analyzable cells they can c…

This study aims to understand how a type of white blood cell called eosinophils contributes to DRESS syndrome, a severe and potentially life-threatening drug allergy. Researchers will compare blood and skin samples from 80 adults with DRESS, other drug rashes, and healthy volunte…

This study examines how germs living on and in the body, along with environmental factors like pollution, may influence allergic diseases such as asthma and eczema in people living in Mali. Researchers will collect samples and health information from 288 participants, both with a…

This study looks at how well venom immunotherapy protects people with Jack Jumper ant allergy years after treatment stops. About 100 adults who completed 3-6 years of therapy and have been off treatment for at least 18 months will have a supervised sting challenge and blood test.…

Stanford University is recruiting 2,500 people with possible allergies to improve how allergies are diagnosed. Researchers will study skin test responses and look at genetic and immune system factors. This study does not test any new treatment, but aims to deepen knowledge of all…

This study is testing a new method to measure allergy-related substances (IgE) in blood and urine. Researchers want to see if this new technique works as well as current tests. About 1,376 children and adults with allergies will provide blood and urine samples during routine visi…

This study aims to better understand sensory symptoms in adults with Tourette syndrome or chronic tic disorders. About 214 participants will fill out yearly questionnaires about urges, attention, mood, and quality of life. The goal is to gather information, not to test a treatmen…

This early-stage trial is testing the safety of a new drug called Exl-111 in 70 healthy volunteers. The study has two parts: one where people get a single dose, and another where they get multiple doses. Some participants will receive the drug, some a placebo, and some an existin…

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung function. Researchers will monitor 100 children, comparing those with allergies to those without, using questionnaires, allergy tests, and breathing tests. The goal is to ide…

This study aims to find the genetic causes behind certain allergic and immune system disorders. Researchers will collect blood, saliva, and tissue samples from up to 10,000 people of all ages, along with some family members. No treatments are given; the goal is simply to learn mo…

This study looks at different forms of IgE (a protein involved in allergic reactions) in healthy volunteers and people with conditions like severe allergies, chronic hives, mastocytosis, and immune deficiencies. Researchers aim to understand how these IgE variations relate to hea…

This study looks at whether babies born with certain self-reactive antibodies are more likely to develop eczema. Researchers will test umbilical cord blood from 500 newborns—some with a family history of allergies or eczema, some without—and follow them for two years. The goal is…

This study is testing a program called VIPP-SD, where parents watch video recordings of themselves with their child and get coaching to improve their sensitivity and discipline. The goal is to help children ages 2 to 6 develop better emotional and social skills. Researchers will …

This study collects blood and skin samples from 200 people with eczema, food allergies, or neither. Researchers will analyze these samples to find shared genetic or biochemical signals. The goal is to better understand how these conditions are connected, which could lead to bette…

This study is a registry that collects contact information from people of all ages who are interested in joining future clinical trials for allergies or asthma. No treatments or tests are given—it simply helps researchers find volunteers for upcoming studies. Anyone from 0 to 100…

This study aims to find noninvasive biomarkers—like substances in urine, blood, or saliva—that can accurately detect active eosinophilic esophagitis in children. Currently, diagnosis and monitoring require repeated endoscopies with biopsies under anesthesia. Researchers will coll…