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The whitening wars: peroxide vs Peroxide-Free bleaching put to the test

NCT ID NCT07818031

Symptom relief Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers at Minia University are comparing two in-office tooth bleaching systems: one that uses peroxide and one that does not. Fifty adults aged 18 to 45 with healthy front teeth will receive one of the two treatments. Over six months, the team will measure how white the teeth become, how well the color holds up, and how much tooth sensitivity participants feel.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
in-office tooth bleaching systems, one peroxide-based and one non-peroxide-based
What this could lead to
If one system performs better, dentists could choose a whitening method that balances brighter teeth with less sensitivity.
What could go wrong
This is a small, single-center study of 50 adults with healthy teeth, so results may not apply to people with dental work, gum disease, or darker stains. Bleaching can cause temporary tooth sensitivity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-45 years. * Good general health. * Presence of all maxillary anterior teeth free from restorations, caries, or structural defects. * Baseline tooth shade suitable for bleaching assessment. * Good oral hygiene and periodontal health. * Willingness to comply with the study protocol and attend all follow-up visits. * Signed informed consent. Exclusion Criteria: * Pregnancy or lactation. * History of tooth hypersensitivity. * Active caries or defective restorations in the anterior teeth. * Intrinsic tooth discoloration (e.g., fluorosis, tetracycline staining). * Ongoing orthodontic treatment. * Smoking. * Use of tooth-whitening products within the previous 6 months. * Allergy to any component of the bleaching materials.

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Conditions

The condition(s) this trial relates to.

allergic disease Tooth Discoloration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tooth discoloration Tooth staining

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Minia University Hospital

    RECRUITING

    Minya, Minya Governorate, Egypt

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