Allergic respiratory disease

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This Phase 2 trial tests PollenVax, a new immunotherapy for people with moderate-to-severe allergic rhinitis caused by mugwort pollen. The treatment is given as four weekly shots before the pollen season. Researchers will compare symptom scores and medication use between the Poll…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests a drug called benralizumab (Fasenra) in 20 adults with severe asthma and a fungal allergy called ABPA. The goal is to see if it can reduce asthma flare-ups that need steroids and improve quality of life. Participants receive the drug as a shot under the skin, and…

This study looks at whether adding a biologic drug to standard treatment can reduce flare-ups in people with allergic bronchopulmonary aspergillosis (ABPA) and severe asthma. About 50 adults will receive a biologic for at least 4 months while continuing their usual asthma medicat…

This study looks at people with a mix of two lung conditions caused by the fungus Aspergillus: chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Researchers want to see if adding steroid pills to the standard antifungal drug itraconazole works better th…

This study tests an experimental drug called SIM0718 for people with asthma that is not well controlled by current inhalers. About 418 adults and teens aged 12 to 75 will receive either the drug or a placebo for one year. The main goal is to see if the drug reduces the number of …

This study is observing 225 adults with severe allergic asthma or chronic hives who are already doing well on the original omalizumab drug. Their doctors have decided to switch them to a biosimilar version called Omlyclo. The main goal is to see if they stay well-controlled for 1…

This study is for people with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by an allergic reaction to a fungus. The treatment involves using a bronchoscope (a thin tube inserted into the airways) to clear mucus plugs and spray an antifungal drug (amphot…

This study tests an experimental drug called LP-003 in 200 adults with moderate to severe allergic asthma. The goal is to see if it reduces asthma attacks and improves breathing compared to a placebo or an active drug. Participants receive injections and are monitored for about a…

This study tests whether a new drug, FB825, can help adults with moderate-to-severe allergic asthma. About 100 participants will receive either FB825 or a placebo. The main goal is to see if FB825 reduces asthma attacks over 24 weeks.

This study is testing a new blood test (called BÜHLMANN BAT) to see if it can help diagnose allergies to peanuts, insect venom, dust mites, hazelnut, and cat dander. About 60 people aged 1.5 years and older who are already being checked for allergies will give one extra tube of b…

This study tests whether a special PET scan (FAPI PET) can better detect active scarring in the lungs of people with fibrotic lung disease. About 50 adults with idiopathic pulmonary fibrosis or fibrotic hypersensitivity pneumonitis will get up to 4 PET/MRI scans. The goal is to i…

This study tests whether inhaling a drug called penehyclidine hydrochloride before surgery can prevent breathing complications in children aged 3 to 7 who are at higher risk. The trial involves 204 kids undergoing minor eye surgery with sevoflurane anesthesia. Researchers will co…

This study tests an inhaled medication called ARO-RAGE in 36 adults with mild asthma that is triggered by allergens. The goal is to see if it improves small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and be monitored for…

This study is testing whether eating a soft chew containing plant stanols every day can reduce asthma symptoms in people with allergic asthma. Plant stanols are known to lower cholesterol, but they may also shift the immune system away from the type of response that triggers asth…

This phase 3 study tests lebrikizumab, an injectable drug, in 450 adults with perennial allergic rhinitis (year-round allergies). The goal is to see if it reduces nasal symptoms like congestion and sneezing compared to a placebo. Participants will be followed for up to 29.5 month…

This study tests a 10-week program called RISE-HP for people with hypersensitivity pneumonitis (HP), a lung condition that can cause anxiety, depression, and poor quality of life. Participants work one-on-one with a trained peer coach (someone who also has HP) to learn coping ski…

This study looks at whether drinking beetroot juice, which is high in nitrate, can help people with fibrotic interstitial lung disease exercise longer. Participants will drink either nitrate-rich or nitrate-free beetroot juice and then do a cycling test. The goal is to see if the…

This study is testing a serious video game designed to improve emotional well-being in teenagers aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to personalize activities that build coping …

This study looks at the safety of a nasal spray called neffy compared to a standard epinephrine shot for treating allergic reactions. It involves 600 people aged 4 and older who have an allergic reaction during a food challenge or allergy shot session. The goal is to see if the s…

This study tests whether a diet low in saturated fats and rich in whole grains, fruits, and vegetables can reduce the severity of atopic dermatitis (eczema) in young adults. Researchers will track changes in skin symptoms and barrier function over two months. The goal is to see i…

This study tests an injection called TQH2722 in 300 adults with seasonal allergic rhinitis (hay fever). The goal is to see if it safely eases symptoms like sneezing, stuffy nose, and itchy eyes when added to standard allergy treatments. Participants will receive the injection and…

This study tests whether a mobile app can help people with allergic rhinitis (hay fever) stay on their allergy immunotherapy (allergy shots or under-the-tongue drops) for the full 3 years. Many people stop early, reducing the treatment's effectiveness. The app provides reminders …

This study tracks how adults with grass pollen allergy use Grassmuno® in everyday medical practice. Researchers will monitor treatment adherence and injection schedules over two years. The goal is to understand how well patients stick with the therapy and how it controls their sy…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests a new method for treating cat allergies called intralymphatic immunotherapy (ILIT), where allergen extracts are injected directly into a lymph node. Thirty-six adults with cat-triggered allergic rhinitis and asthma will receive 3-4 ultrasound-guided injections. T…

This study is testing whether a natural supplement called 5HTP can improve breathing and reduce anxiety in children aged 8-18 with mild to moderate asthma and allergies. About 20 participants will be randomly assigned to take either 5HTP or a placebo, then switch groups later. Th…

This study tests a new under-the-tongue treatment (MM09) for people with rhinitis or rhinoconjunctivitis caused by house mite allergy, with or without mild asthma. About 736 participants aged 12 to 65 will receive either MM09 or a placebo to see if it reduces allergy symptoms and…

This study tests whether smelling lavender essential oil during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly assigned to receive either lavender aromatherapy or a placebo (odorless liquid). Participants will rate their anxie…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study tests whether a daily probiotic blend can improve quality of life for adults with persistent allergies to dust mites, cats, or dogs. For 12 weeks, 98 participants will take either the probiotic or a placebo and track their symptoms and antihistamine use. The goal is to…

This study is testing a seawater spray mixed with essential oils to see how well it relieves nasal congestion from colds, sinus infections, or allergies. About 114 people aged 12 and older will use the spray for 7 days. The main goal is to see if nasal blockage improves after 3 d…

This study tests a new nasal spray called ALDP001 for people with seasonal allergic rhinitis (hay fever). Researchers want to find the best dose and how often to use it to reduce symptoms like sneezing, stuffy nose, and runny nose. About 164 adults will take part, and their sympt…

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either phlegm-guided treatment or stan…

This study is testing a new seawater spray with essential oils to see if it safely relieves nasal congestion from colds, sinus infections, or allergies. About 101 people aged 12 and older will use the spray for 8 days. The main goal is to check if nasal stuffiness improves by at …

This study tests a new antibody drug for people whose seasonal allergies (hay fever) are not controlled by standard treatments. The drug targets a protein involved in allergic inflammation. About 120 adults will receive either the antibody or a placebo, and researchers will measu…

This phase 3 trial tests whether a new drug called DW1807 works better than another drug (DW1807-R2) for people with year-round allergic rhinitis who also have asthma. About 274 adults will take one of the two drugs daily for 4 weeks. The main goal is to see if DW1807 improves na…

This Phase 3 trial tests an injection called GR1802 for people with seasonal allergic rhinitis (hay fever) that is not well controlled by standard treatments. The drug is a lab-made antibody that blocks a key inflammation signal. About 150 adults will receive either GR1802 or a p…

This study tests an injection called SHR-1819 in 100 adults with seasonal allergic rhinitis (hay fever). Participants will receive either the drug or a placebo to see if it reduces daily nasal symptoms like sneezing and stuffiness. The trial is double-blind, meaning neither patie…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study is developing a machine learning model to predict the risk of relapse within one year for people with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by an allergic reaction to a fungus. Researchers will collect data from 300 patients across mul…

This study tests a printed decision aid that helps people with chronic hypertrophic rhinitis compare five surgical options. About 158 participants will either get standard counseling or the extra aid. Researchers will measure how certain patients feel about their choice and wheth…

This study looks at why people with interstitial lung disease (ILD) often feel breathless and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 ILD patients and test how extra oxygen affects …

This observational study aims to find early biomarkers that can predict if a person's lung scarring (pulmonary fibrosis) will get worse quickly. Researchers will follow 450 adults with various types of interstitial lung disease, including IPF and other fibrotic conditions. Partic…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Using advanced PET and MRI scans, researchers will measure collagen buildup and tissue damage. The goal is to better understand the effec…

This registry is following 3,000 adults with idiopathic pulmonary fibrosis (IPF) or other chronic fibrosing interstitial lung diseases (ILDs) to understand how these conditions progress over time. Researchers collect information on symptoms, treatments, quality of life, and store…

This study is looking for 530 adults with hay fever in South-Eastern Australia to help create a tool that predicts thunderstorm asthma. Participants will have allergy and lung function tests, then track their symptoms during spring for two years. The goal is to find warning signs…

This study is testing whether a nasal allergen provocation test (NAPT) can help doctors start and monitor allergy immunotherapy more effectively. Researchers will follow 200 adults with allergic rhinitis who are beginning immunotherapy, using the NAPT along with blood tests and s…

This study tests whether special PET and MRI scans can predict how fast lung scarring (pulmonary fibrosis) will get worse in 60 adults aged 18-80 with certain types of this disease. Participants will have scans and breathing tests over 2 years. The goal is to see if these imaging…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

Stanford University is recruiting 2,500 people with possible allergies to improve how allergies are diagnosed. Researchers will study skin test responses and look at genetic and immune system factors. This study does not test any new treatment, but aims to deepen knowledge of all…

This study is testing a new method to measure allergy-related substances (IgE) in blood and urine. Researchers want to see if this new technique works as well as current tests. About 1,376 children and adults with allergies will provide blood and urine samples during routine visi…

This study looks at 1,000 children (ages 5-18) with dust mite allergies to see if customizing allergy shots based on their specific mite protein sensitivities leads to better symptom control. Participants get a detailed blood test to map their allergy profile and are followed for…

This study looks at 100 adults with fibrosing interstitial lung diseases (a type of lung scarring) to see if things like mold, dust, air pollution, and other home factors make the disease progress faster. Researchers will compare patients whose disease is getting worse to those w…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung function. Researchers will monitor 100 children, comparing those with allergies to those without, using questionnaires, allergy tests, and breathing tests. The goal is to ide…

This long-term study follows 1,000 people with eczema and related allergies, plus healthy volunteers, to see what factors help the disease go into remission. Researchers will collect medical and lifestyle data to find patterns and possible biomarkers. The goal is to better unders…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study is testing a simple questionnaire to see how well it measures allergic rhinitis (hay fever) control in children aged 5 to 11. The goal is to give doctors a reliable way to track symptoms and adjust treatments. About 135 children will fill out the questionnaire during a…

This study is testing whether a simple symptom score questionnaire (SCST) is acceptable and useful for patients with allergic rhinitis during ENT check-ups. The goal is to see if this tool helps doctors monitor severity and response to treatment consistently. Thirty adults will p…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18–80 and follow them for 6 months. The goal …

This study looks at 60 adults aged 35-75 with allergic or eosinophilic asthma to see if their symptoms, breathing problems, and frailty levels differ. Researchers will measure lung function, breathlessness, fatigue, and quality of life. The goal is to help health professionals de…

This study explores whether functional MRI can help doctors tell different types of interstitial lung disease apart and track how they change over time. About 200 adults with certain lung conditions will get MRI scans alongside standard CT scans. The goal is to see if MRI can pro…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study aims to better understand bronchiectasis, a chronic lung disease, in Chinese patients. Researchers will collect data from 1500 adults to identify different disease types and their underlying causes. The goal is to improve diagnosis and tailor treatments for each patien…

This study looks at how the lungs of people with asthma react when exposed to common allergens like cat hair or dust mites. Researchers will use a bronchoscope to deliver tiny amounts of allergen into the lung and then collect fluid to study which immune cells show up. The goal i…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis, idiopathic pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to su…

This study follows 500 adults with progressive pulmonary fibrosis (a type of lung scarring) for 24 months. Researchers will collect medical images, lung function tests, and blood samples to better classify the disease and predict its course. The goal is to improve how doctors ide…

This study looks at how changing sleep time affects the immune system and breathing in urban children with asthma. Researchers will ask some children to go to bed 90 minutes later for a week, while others keep their usual bedtime. They aim to understand if short sleep worsens ast…