Peking Union Medical College Hospital

This study tests two treatment strategies for people with IgG4-related disease (IgG4-RD) that affects superficial organs like glands or lymph nodes. About 60 adults will receive either prednisone plus iguratimod or prednisone plus leflunomide for 12 months. The goal is to see whi…

This study tests whether a special type of radiation given in very small, frequent doses before CAR-T cell therapy can safely and effectively treat people with relapsed or refractory diffuse large B-cell lymphoma. About 20 adults who have not responded to at least two prior treat…

This early-stage trial tests an mRNA drug called XH-02 in 15 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone (PTH). The drug is injected under the skin to help replace the missing hormone. The main goal is to check safety, while also measuring…

This study tests whether a combination of acupoint photodynamic therapy (a type of light treatment) and a traditional Chinese medicine called Dingkun Dan can improve ovarian function in women aged 25 to 40 with diminished ovarian reserve (DOR). Participants will be randomly assig…

This study tests whether combining two drugs, camrelizumab and apatinib, with chemotherapy can help women with a rare pregnancy-related cancer called gestational trophoblastic neoplasia (GTN). It includes two groups: those with very high-risk disease who haven't had treatment, an…

This early-stage study tests a new mRNA drug (XH02) that helps the body produce parathyroid hormone (PTH), which is missing in people with hypoparathyroidism. The goal is to see if it is safe and can restore normal calcium and phosphorus levels. Six adults aged 18 to 65 with chro…

This study tests whether tocilizumab, a drug used for arthritis, can improve symptoms and breathing in adults with a rare form of dermatomyositis (anti-MDA5+). About 110 participants will receive either the drug or a placebo every two weeks for two months. The goal is to see if i…

This study tests a new way to repair complex aortic aneurysms (bulging blood vessels) using special stents. The goal is to see if the BAO-G technique is safe and works well for up to 5 years. About 60 adults with certain types of aortic aneurysms will take part. The approach uses…

This early-phase study tests a new radioactive drug (177Lu-P17-087/088) in 30 men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The drug seeks out cancer cells and delivers radiation directly to them. The study first checks safety and ho…

This study tests a newer type of radiation therapy called online adaptive radiotherapy (oART) for people with cervical cancer. The goal is to see if oART causes fewer side effects and controls the tumor better than standard image-guided radiotherapy. About 124 adults aged 18-80 w…

This study tests whether giving a combination of two immunotherapy drugs (iIparomlimab and tuvonralimab) plus a targeted therapy (lenvatinib) before surgery can help shrink liver cancer and lower the chance of it coming back. About 33 adults with resectable liver cancer at high r…

This study looks at whether starting with one bone-strengthening drug (teriparatide) for 6 months and then switching to another (denosumab) works better than taking denosumab alone to prevent new fractures in people with osteoporosis who have already broken a bone. About 2,478 me…

This study tests whether a comprehensive treatment plan can reduce serious heart events in people with rapidly-progressive coronary artery disease driven by inflammation. Researchers will compare each participant's outcomes before and after treatment. The study enrolls 39 adults …

This small study tests whether a fecal microbiota transplant (FMT) combined with a special nutritional drink can help people with chronic constipation. Five adults with functional constipation will receive the treatment and be monitored for changes in bowel habits and side effect…

This study tests an experimental mRNA drug called XH-02 in 60 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone (PTH). The drug is designed to help the body produce PTH, which controls calcium levels. Researchers want to see if it …

This study tests whether adding two immunotherapy drugs (tuvonralimab and iparomlimab) to standard chemotherapy before surgery helps remove bile duct cancer more completely. About 45 adults with resectable or borderline-resectable cancer will receive 2-4 cycles of treatment, then…

This study tests a drug called glofitamab in 20 Chinese adults with a type of blood cancer (diffuse large B-cell lymphoma) that has returned or not responded after at least two prior treatments. The goal is to see if the drug can shrink tumors and improve survival, while monitori…

This study tests whether adding lenalidomide to standard prednisone treatment can better control active IgG4-related disease (IgG4-RD), a rare condition causing swelling and damage in organs. About 198 adults with active disease will receive either a low or higher dose of lenalid…

This study looks at whether berberine, a natural compound, can help blood thinners work better in people who have had a heart stent. About 64 adults who are already taking aspirin and clopidogrel will receive different doses of berberine or no extra treatment for up to 13 weeks. …

This study tests whether giving a new immunotherapy drug (QL1706) along with standard chemotherapy before surgery can help shrink tumors in people with a certain type of lung cancer (non-small cell lung cancer). About 30 adults with stage IIB to IIIB lung cancer will receive the …

This study tests whether giving immunotherapy before surgery can help completely remove T4 colon cancer in people whose tumors have a specific DNA repair problem (dMMR). About 18 adults aged 18-75 with newly diagnosed, non-spread colon cancer will receive immunotherapy first, the…

This study tests a drug called pyrotinib as a first treatment for people with advanced non-small cell lung cancer that has a specific change in the HER2 gene. The drug works by blocking certain proteins that help cancer grow. About 18 adults with stage IIIB or IV lung cancer who …

This study compares different immunosuppressive medicines to treat idiopathic membranous nephropathy, a kidney condition where the immune system attacks the kidneys. About 200 adults with severe protein in their urine will receive one of several drug regimens. The goal is to see …

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatments (chemotherapy or lenvatinib) can help shrink tumors and slow disease progression in people with advanced bile duct or gallbladder cancer. About 60 adults with inoperable cancer will receiv…

This study tests whether adding interventional procedures (like targeted chemo or radiation) to standard immunotherapy and targeted therapy can better control advanced liver cancer. About 300 adults with advanced liver cancer will be split into two groups: one gets only drug ther…

This study tests a two-step treatment that uses Western medicine to quickly restart menstruation and Chinese medicine to support long-term balance in women with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or over-exercise). Researchers will track…

This study tests a precision medicine approach for people with advanced bile duct cancer that has a specific genetic change called an IDH1 mutation. Participants will receive a combination of ivosidenib (a targeted pill) plus either lenvatinib or an immunotherapy drug. The goal i…

This study tests if a newer, less invasive laparoscopic surgery (with special tumor-safe steps) works as well as traditional open surgery for stage IB2 cervical cancer. About 524 women will be randomly assigned to one of the two surgeries and followed for 4.5 years. The goal is t…

This study tests whether a medication (edaravone dexborneol) taken as a tablet under the tongue can help people recover from a stroke caused by small vessel disease. About 600 adults aged 30–80 who had a recent small stroke will receive either the drug or a placebo for 24 weeks, …

This study tests a new combination treatment for people with advanced bile duct cancer that has not responded to standard first-line therapy. The treatment uses a special form of the chemotherapy drug paclitaxel (polymer micellar) together with immunotherapy. The goal is to see i…

This study looks at how losing weight and then regaining it (weight cycling) affects hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). Researchers will follow 425 women with PCOS, some at normal weight and some overweight, as they try to lose w…

This study tests a new type of PET scan (68Ga-Pentixafor) to see if it can better tell apart the two main types of Cushing's syndrome and find the exact location of the problem. About 160 people with suspected or confirmed Cushing's will get this scan, and results will be compare…

This study tests a special PET/CT scan using a new tracer called [68Ga]Ga-NI-FAPI-04 to better see diseases linked to fibroblast activation, such as tumors, heart problems, lung scarring, and immune conditions. About 30 adults, including healthy volunteers, will get the scan to s…

This study is testing a new type of PET scan that uses a special tracer to take clearer pictures of cancers, heart problems, and immune diseases. Researchers will check how safe the tracer is and how well it finds disease compared to standard methods. About 600 adults will take p…

This study tests a new type of PET/CT scan that uses a radioactive tracer called Al18F-NOTA-LM3 to find tumors that cause a rare bone-softening condition called tumor-induced osteomalacia. About 40 adults with suspected or confirmed TIO will receive both the new scan and a standa…

This study tests a new imaging agent called 68Ga-P16-093 against the standard 68Ga-PSMA-11 for detecting prostate cancer. Fifty men with untreated prostate cancer will receive both PET scans within a week. The goal is to see which agent finds more tumors and gives clearer images.

This study tests a newer type of PET/CT scan (Al18F-NOTA-LM3) against the current standard (68Ga-DOTATATE) to see which finds tumors more accurately in people with rare adrenal or nerve tumors called pheochromocytoma or paraganglioma. About 40 adults aged 18-80 with suspected or …

This study tests a new bedside method using saline contrast and electrical impedance tomography (EIT) to diagnose acute pulmonary embolism (blood clots in the lungs). It compares this method to the standard CT scan (CTPA) in 343 adults with suspected clots. The goal is to see if …

This study tests whether the drug lenalidomide can safely and effectively treat mouth ulcers in adults with a rare condition called mucosal Behçet's syndrome. About 42 people with active mouth sores will take the drug for 12 weeks. The main goal is to see if the ulcers completely…

This study tests a new type of radiation therapy that adjusts the beam in real time to better target the area where breast cancer was removed. About 40 women who had breast cancer surgery will receive either a moderate or very short course of this adaptive radiation. The goal is …

This study tests whether a gentle mind-body exercise called Baduanjin can help reduce low back and pelvic pain during pregnancy. About 84 pregnant women will do the exercise for 12 weeks. Researchers will measure pain levels and quality of life to see if it helps.

This study looks at whether spraying a low-dose numbing medicine (lidocaine) under the diaphragm during single-incision laparoscopic surgery can reduce shoulder pain afterward. About 100 women having surgery for benign conditions like ovarian cysts or uterine fibroids will take p…

This study tests whether a dietary supplement called β-alanine can reduce fatigue in people with advanced liver cancer who are receiving standard immunotherapy. About 158 participants will take either the supplement or a placebo alongside their regular treatment. The main goal is…

This study looks at whether ear acupuncture can help with delayed stomach emptying after certain abdominal surgeries (like Whipple or stomach cancer surgery). Researchers will track symptoms like nausea and fullness in 159 adults aged 40-70. The goal is to see if this simple, non…

This study tests whether a virtual reality family support system can lower the risk of delirium (sudden confusion) in ICU patients who need a breathing tube. About 102 adults will use the VR system until their breathing tube is removed. Researchers will track delirium, medication…

This study compares two versions of a procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. About 52 adults will be randomly assigned to get either the standard circular muscle cut or a full-thickness…

This study is testing whether a special PET scan called FAPI PET/CT can detect inflammation in people with Sjögren's syndrome, an autoimmune disease that causes dryness. Researchers will scan 60 adults and compare the results with blood tests and scans from tumor patients. The go…

This study aims to find out if two types of HIV medications (NNRTI and INSTI) cause different levels of fatty liver disease in people with HIV. Researchers will screen 200 HIV patients using ultrasound to measure liver fat and stiffness. The goal is to learn which drug class may …

This study is testing whether special PET scans (PSMA and FAPI) can give doctors a clearer picture of Sjögren's syndrome, an autoimmune disease that damages glands. Researchers will compare scans from 60 people with Sjögren's, healthy volunteers, and prostate cancer patients. The…

This study looks at 80 critically ill ICU patients to see if changes in gut blood flow after feeding can predict acute gastrointestinal injury. Using bedside ultrasound, researchers will monitor the main artery supplying the gut and link those readings to feeding problems. The go…

This study looks at 400 women with HIV to understand how the balance of bacteria in the gut and vagina might make them more likely to get HPV and develop cervical lesions. Researchers will collect samples to track HPV infections and cervical changes over time. The goal is to lear…

This study is testing a new, radiation-free imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of 'good' fat that burns energy. Researchers will compare BAT activity in 100 healthy adults and people with metabolic syndrome, both at rest a…

This study is for adults with ARDS (a severe lung condition) who are on a breathing machine and need to lie on their stomach to help their lungs work better. Researchers will use a special 3D imaging technique called EIT to watch how air and blood flow change in different parts o…

This study will observe 3,000 Chinese patients with pancreatic cancer who are already receiving a drug called irinotecan liposome. Researchers will collect data on side effects, survival, and tumor response to see how well the treatment works in everyday medical practice. No new …

This study looks at whether general anesthesia given to young children with congenital scoliosis (a spine curve present at birth) affects their long-term thinking and behavior. Researchers will test 150 children aged 6-16 using IQ and behavior checklists. The goal is to provide c…

This study is testing a new imaging agent called 68Ga-NYM096 to see how well it shows up in various cancers, including tumors that have spread. About 120 adults with confirmed cancer will receive the tracer and undergo a PET/CT scan. The goal is to measure how strongly the tracer…

This study watches 500 cancer patients who had immune-related side effects from immunotherapy drugs. Researchers collect data and samples to understand these side effects better and see if it's safe to restart the same treatment. The goal is to help doctors make safer decisions a…

This study is for people with a type of heart disease linked to inflammation. Researchers want to learn about the symptoms, treatments, and health outcomes of 120 participants. The goal is to better understand this condition, not to test a new treatment.

This study is testing whether listening to bowel sounds can help doctors predict which patients with acute pancreatitis will develop a severe form of the disease. Researchers will monitor 352 adults for 48 hours using a special device that records belly sounds. The goal is to see…

This study follows 66 people with chronic viral infections of the brain, such as PML, to see if giving immune checkpoint inhibitors can improve their long-term recovery. Researchers will track disability, brain scans, and virus levels over one year. The goal is to understand whet…

This study looks at 50 adults on breathing machines for acute respiratory failure. Researchers will compare two techniques—electrical impedance tomography (a type of imaging) and the recruitment-to-inflation ratio (a simple calculation)—to see how well they predict lung recruitme…

This study looks at 1000 adults having moderate- to high-risk surgery to see if the type of anemia they have before surgery affects their chance of complications like heart injury, kidney injury, or stroke. Researchers will compare people with iron-deficiency anemia, anemia from …

This study tests a new, faster MRI scan for the abdomen and pelvis that uses artificial intelligence to create clear images. About 300 adults who need an MRI as part of their care will get both the standard and the fast scan, so doctors can compare them. The goal is to see if the…

This study aims to understand why some people with coronary artery disease get worse quickly due to inflammation. Researchers will compare 20 patients with inflammation-linked rapid disease to 10 patients with standard disease. They will look at medical history, lab tests, and im…

This study collects thousands of breast ultrasound images and has expert doctors label them. Then, different AI models are tested to see how accurately they can identify cancer compared to the experts. The goal is to build a standard way to evaluate AI for breast imaging, not to …