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Could a simple saline test replace CT scans for lung clots?

NCT ID NCT07190079

Diagnosis Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new, radiation-free bedside test using saline contrast and electrical impedance tomography (EIT) against standard CT scans (CTPA) for diagnosing acute pulmonary embolism (blood clots in the lungs). Researchers will enroll 343 patients with suspected or confirmed PE to see if the EIT method can accurately detect clots. If it works, it could offer a safer, quicker option for diagnosis, especially for patients who cannot undergo CT scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
saline contrast
What this could lead to
If successful, this could provide a safer, bedside diagnostic tool for acute pulmonary embolism, reducing reliance on radiation-based CTPA.
What could go wrong
This is an early-stage observational study, not a treatment trial. The new method may not match CTPA accuracy, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 343 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with clinically suspected or confirmed acute pulmonary embolism (PE) presenting with acute respiratory failure.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with clinically suspected or confirmed acute pulmonary embolism (PE) presenting with acute respiratory failure; 2. Availability of CTPA results within 24 hours or scheduled to undergo CTPA within the next 24 hours; 3. Age \>18 years; no gender restrictions; 4. Presence of central venous access (internal jugular or subclavian vein) or peripheral forearm venous access; 5. Willingness to participate with signed informed consent from either the patient or legal guardian. Exclusion Criteria: 1. Pregnancy or lactation; 2. Relative contraindications to EIT examination (e.g., chest wall wounds at electrode belt placement site, presence of pacemakers); 3. Severe hypernatremia (serum sodium \>155 mmol/L); 4. Inability to maintain expiratory breath-hold for ≥8 seconds; 5. BMI \>50 or severe thoracic deformities; 6. Current extracorporeal membrane oxygenation (ECMO) therapy.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pulmonary embolism

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

    RECRUITING

    Beijing, Beijing Municipality, 100730, China

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