Peking Union Medical College Hospital

This study tests a combination of two drugs—envafolimab (an immunotherapy) and axitinib (a targeted therapy)—in 30 people with advanced kidney cancer that has not been treated before. The goal is to see if the combo can shrink tumors and control the disease safely. Participants r…

This study tests a new way to set breathing machines for adults with severe lung injury (ARDS). Doctors will use a special imaging tool called EIT to tailor ventilator settings to each patient. The goal is to see if this personalized approach lowers the chance of death within 28 …

This study will enroll 2000 adults diagnosed with type 2 diabetes before age 40. Researchers will combine traditional Chinese medicine data with modern tests like blood work and genetic information to create a personalized treatment plan. The goal is to improve blood sugar contro…

This study tests a daily pill called linprixel for people with autoimmune hemolytic anemia that hasn't improved with other treatments. The goal is to see if the drug can control the disease by improving blood counts. About 22 adults will take the pill for up to 12 weeks, with the…

This study tests a digital therapy app designed to help pregnant women with gestational diabetes manage their blood sugar. The app provides personalized diet and activity plans, risk alerts, and educational tips. Researchers will enroll 160 women to see if using the app improves …

This study tests whether combining two drugs—orelabrutinib and romiplostim—can improve platelet counts and allow patients with chronic immune thrombocytopenia (ITP) to stop treatment. About 28 adults who haven't responded well to standard therapy will take the combo for 24 weeks.…

This study tests a combination of three drugs (disitamab vedotin, lenvatinib, and a PD-1 inhibitor) in 65 adults with advanced HER2-positive bile duct cancer that cannot be removed by surgery. The goal is to see if the combo shrinks tumors and controls the disease. Participants w…

This study compares two treatments for blocked arteries in the leg: a special balloon with medicine alone, or the same balloon plus a device that removes plaque first. The goal is to see which approach keeps the artery open longer. About 408 adults with leg artery blockages will …

This study compares a four-drug combination (Isa-VRD) against the standard three-drug regimen (VRD) for people newly diagnosed with high-risk multiple myeloma who are not eligible for a stem cell transplant. The goal is to see if adding isatuximab helps achieve deeper cancer remi…

This study tests whether giving a PCSK9 inhibitor (a drug that lowers cholesterol) soon after a stroke can help people recover better. It includes 1212 adults who had a stroke due to narrowed arteries in the brain. Participants will receive either the drug or a placebo, and recov…

This study tests a combination of three drugs (cyclosporine, eltrombopag or hetrombopag, and romiplostim) in 43 adults newly diagnosed with severe aplastic anemia or a related condition requiring blood transfusions. The goal is to see if the treatment can restore blood cell produ…

This early-stage study tests an inhaled mRNA drug (BMD003) in 24 Chinese patients aged 12 and older with cystic fibrosis. The goal is to see if the treatment is safe and can improve lung function and quality of life. Participants will receive multiple doses over a year, with clos…

This study tests a special stent that releases estrogen to help the uterus heal after an induced abortion. About 200 women will receive either the estrogen-releasing stent or a plain stent. Researchers will measure uterine lining thickness, bleeding, and side effects over 90 days…

This study tests a daily oral drug called orelabrutinib in 50 adults whose autoimmune hemolytic anemia (AIHA) has not responded to standard treatments. The goal is to see if the drug can control the disease by stopping the immune system from destroying red blood cells. Participan…

This early-phase trial tests a new treatment for people with advanced pancreatic cancer whose tumors have stopped responding to chemotherapy. The therapy uses specially engineered immune cells (CAR-M) designed to recognize and attack cancer cells that have a protein called C-MET.…

This study tests a drug called romiplostim N01 in 43 adults with severe anemia that did not improve with standard treatments. The anemia was caused by chemotherapy or radiation therapy for cancer. The goal is to see if the drug can safely increase blood cell counts and reduce the…

This early-stage study tests the safety of a drug called rituximab in 5 boys aged 6 to 10 with Duchenne muscular dystrophy who can still walk. The drug works by lowering certain immune proteins to possibly slow muscle damage. Researchers will monitor side effects and check motor …

This study tests a new drug combination (SHR-1811 plus bevacizumab) as a second-line treatment for people with metastatic colorectal cancer that has worsened after initial therapy. About 80 adults aged 18-75 will participate to see if the combo shrinks tumors and delays cancer gr…

This early-stage trial tests a new radioactive drug, 161Tb-LNC1011, in 15 men with advanced prostate cancer that has stopped responding to hormone therapy. The drug is designed to seek out and deliver radiation directly to cancer cells. The main goals are to check safety and find…

This study tests whether adding enarodustat to standard cyclosporine treatment helps people with newly diagnosed transfusion-dependent non-severe aplastic anemia. About 90 adults who cannot have a stem cell transplant will receive either the combo or cyclosporine alone. The goal …

This study tests whether adding a traditional Chinese herbal formula (Xiehe DOR Bushen Tongzhi Formula) to standard ovulation induction therapy improves the chance of natural pregnancy in women aged 22-39 with diminished ovarian reserve (DOR). Participants will receive either the…

This study tests a computer program that gives real-time feedback to doctors and nurses to help them set ventilators in a way that protects the lungs of critically ill patients. The goal is to see if this approach helps more patients receive lung-protective ventilation, which can…

This study tests whether a drug called butylphthalide can improve recovery and prevent further strokes in people who have had a minor stroke. About 1,200 adults aged 40-80 will take the drug or a placebo daily for 12 months. Researchers will measure survival, stroke recurrence, d…

This study tests a combination of three drugs (cyclosporine, eltrombopag/hetrombopag, and romiplostim) in 43 adults newly diagnosed with severe aplastic anemia or a related condition that requires blood transfusions. The goal is to see if the combo can help the bone marrow produc…

This study tests whether adding enarodustat to the standard drug cyclosporine works better than cyclosporine alone for adults with a type of anemia that requires regular blood transfusions. The goal is to see if the combination can improve blood counts and reduce the need for tra…

This study tests whether denosumab, a bone-strengthening drug, can help prevent fractures in people with type 2 diabetes who are at high risk for broken bones. About 358 adults aged 45 and older with long-standing diabetes or related complications will receive denosumab plus stan…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps more women have a baby. It includes about 792 women under 40 with infertility and specific fibroids (4-6 cm, not distorting the uterine cavity). Half will have …

This study tests whether a traditional Chinese herbal formula, Bushen Tongzhi, can improve pregnancy rates in women with diminished ovarian reserve (low egg supply) who are doing IVF. About 348 women will take either the herbal formula or a placebo for up to 6 months during their…

This study tests a drug called romiplostim N01 in 43 adults whose severe anemia did not improve after standard treatments. The anemia was caused by chemotherapy or radiation for cancer. The goal is to see if the drug can help the bone marrow make more blood cells and improve symp…

This study tests two extra treatments—lying in a head-down position (Trendelenburg) and a traditional Chinese herbal formula—added to standard care for people with severe pneumonia and breathing failure. About 1,500 ICU patients will take part. The goal is to see if these additio…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant) combined with prebiotics can help people with chronic constipation that hasn't improved with standard treatments. Nineteen adults with refractory constipation will receive the treatment and …

This phase 2 trial tests whether a higher radiation dose (58.75 Gy) given before surgery can improve complete response rates in 156 adults with locally advanced rectal cancer, compared to the standard dose (50 Gy). Participants receive radiation plus chemotherapy, then surgery or…

This study tests a new type of PET/CT scan that uses a special tracer (68Ga-BCMA nanobody) to find multiple myeloma lesions in the body. Researchers will compare it to the standard FDG-PET/CT scan to see if it detects more disease spots. The goal is to improve diagnosis, treatmen…

This study aims to improve how gestational diabetes is diagnosed by using continuous glucose monitoring (CGM) technology instead of the standard single blood test. Researchers will enroll 300 pregnant women early in pregnancy (within 14 weeks) and use CGM data along with AI tools…

This early-stage study will test a new imaging agent called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The goal is to see if this PET scan tracer can safely highlight brain changes linked to these conditions and help with diagnosis. P…

This study will test an artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, macular degeneration, and glaucoma. Researchers will collect 2,000 real-world scans and see how well the AI can identify each…

This study aims to see if a new DNA test (CISENDO) on cells from a routine cervical smear can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. About 3,500 participants will provide a cervical sample and undergo standard hysteroscopy fo…

This study tests whether giving ondansetron (a nausea medicine) before an emergency upper endoscopy can help patients feel less discomfort and gag less during the procedure. About 80 adults with upper GI bleeding will receive either ondansetron or a placebo before the scope. The …

This study tests whether playing a recording of a loved one's voice during nursing care can reduce anxiety and depression in critically ill patients. About 234 adults on breathing machines in the ICU will receive this voice-cloning care until their breathing tube is removed. Rese…

This study tests if a new drug called Tegileridine is as good as morphine for pain relief in teenagers after scoliosis surgery. About 171 teens will receive either Tegileridine or morphine through a pump they control. Researchers will compare pain scores and side effects over 48 …

This study follows 200 adults with diffuse large B-cell lymphoma whose cancer got worse after treatment with polatuzumab vedotin. Researchers will track what treatments doctors try next and how well they work. The goal is to gather real-world data to help guide better treatment d…

This study will enroll 200 adults scheduled for surgery to remove rare adrenal tumors called pheochromocytomas or paragangliomas. Researchers will test a model that uses 6 factors to predict if a patient will have severe blood pressure swings during the operation. They will also …

This study will enroll 1,000 adults at high risk for diabetes to test whether continuous glucose monitors combined with artificial intelligence can detect prediabetes earlier and more accurately than current methods. Participants will wear a glucose monitor and provide other heal…

This study will follow 6,743 adults with obesity-related cancers (like breast, colon, or lung cancer) to see how changes in body fat and muscle affect survival, cancer return, and quality of life. Researchers will use imaging scans to measure body composition, going beyond simple…

This study aims to find hidden DNA changes in families where a baby has a birth defect but standard genetic tests came back normal. Researchers will use advanced DNA sequencing to create a detailed map of these changes, specifically for the Chinese population. The goal is to impr…

This study looks at why coronary artery disease (blockages in heart arteries) gets worse rapidly in some patients. Researchers will compare 34 people with fast-progressing disease to 18 with slow-progressing disease, checking their medical history, lab results, and imaging. The g…

This study observes how patients with extensive-stage small cell lung cancer are treated in everyday hospital settings and how they respond. Researchers will collect data from medical records and follow participants for about 3 months at a time. The goal is to learn which treatme…

This study looks at where colon cancer spreads to lymph nodes in the small bowel area for people with cecal or early ascending colon cancer. Researchers will examine tissue removed during surgery to find patterns of spread. The goal is to help surgeons decide how much bowel to re…

This study looks at how the bacteria in your gut might influence how well a drug called glofitamab works against a type of lymphoma (DLBCL). Researchers will collect stool samples from 30 patients before, during, and up to one year after treatment to see if certain gut bacteria a…