Cloned voices of family may soothe ICU anxiety, new trial hopes
NCT ID NCT06743321
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether playing a cloned recording of a loved one's voice can help reduce anxiety in critically ill patients on breathing machines in the ICU. The voice is used three times a day for reassurance and preparation. Researchers will track anxiety, depression, and recovery in 234 participants.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Speech-to-speech voice-cloning care (SVCC) – a behavioral intervention using cloned voices of loved ones
- What this could lead to
- If it works, this could offer a simple, non-drug way to ease anxiety and improve mental health for critically ill patients in the ICU.
- What could go wrong
- This is an early-stage study with no prior results. The effect may be small, and benefits might not apply to all ICU patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 234 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Expected mechanical ventilation time \> 24 hours; * Expected ICU stay \> 72 hours; * Language: Chinese; * Richmond Agitation-Sedation Scale (RAAS) score ≥ -2 points; * Hemodynamic stability. Exclusion Criteria: * Severe hearing impairment or worse (Grade 3 or higher according to WHO's Grades of hearing impairment); * Disorders of consciousness or comprehension; * Mental or psychological disorders that are being treated with medication; * Head trauma or surgery resulting in an inability to wear earphones.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
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