Emory University

This early-stage study tests a personalized vaccine made from a patient's own tumor, combined with immunotherapy drugs, for triple negative breast cancer. The goal is to see if the vaccine is safe and can help the immune system attack cancer cells. About 18 adults with various st…

This study looks at whether a single booster dose of a meningitis B vaccine can protect young adults who got a different meningitis B vaccine at least 2.5 years ago. Researchers will measure immune responses in 125 healthy participants before and after the booster. The goal is to…

This study tests an investigational drug called eptacog beta for people with Glanzmann thrombasthenia, a rare inherited bleeding disorder. Over 9 months, about 6 participants will use the drug to treat serious bleeding episodes, with an optional extension to see if regular infusi…

This early-stage trial tests a new drug (MRX-2843) combined with a standard treatment (osimertinib) for people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest and most effective dose and to see how well the combination works. About 69 particip…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. Standard care includes ICU monitoring and blood pressure control. The study will enroll 600 adults aged 18-70 with a specific type of br…

This early-phase study tests a new drug called tegavivint combined with the chemotherapy gemcitabine in people whose osteosarcoma (a type of bone cancer) has returned or not responded to standard treatments. The main goal is to find the safest dose of tegavivint when given with g…

This study tests whether a combination of three drugs—belantamab, pomalidomide, and dexamethasone—can keep high-risk multiple myeloma from returning after a stem cell transplant. About 34 adults who have already had a transplant and are in partial remission or better will take th…

This study tests whether adding celecoxib (a painkiller) to standard immunotherapy drugs (durvalumab and tremelimumab) can help control advanced liver cancer that has spread. About 39 adults with advanced or metastatic hepatocellular carcinoma will receive the combination. The go…

This study tests whether atovaquone, a drug normally used for infections, can help people with a type of ovarian cancer that no longer responds to standard platinum chemotherapy. About 28 adults with platinum-resistant high-grade serous ovarian cancer will take atovaquone. The go…

This study looks at whether a low, personalized dose of aPCC (FEIBA) is safe and helps control bleeding in children and adults with hemophilia A who have inhibitors and are already taking emicizumab. Researchers will measure how well the blood clots after the dose and watch for s…

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). It also tests if a gentle nerve stimulation device can boost the benefits. The study involves 150 adults with moderate CKD and measures changes in nerve acti…

This study tests whether simple digital checklists and reminders can help doctors prescribe the best combination of heart failure medications to more patients. Researchers will enroll 4,000 adults with heart failure and a weak heart pump. The goal is to see if these tools increas…

This study tests whether proton beam radiation, a precise type of radiation that spares healthy tissue, can reduce the risk of cancer returning in people with non-small cell lung cancer that has spread to chest lymph nodes. Participants have already had surgery and chemotherapy. …

This study tests whether adding a common cholesterol-lowering drug (lovastatin) to an immunotherapy (pembrolizumab) can help shrink tumors in people with head and neck cancer that has returned or spread. About 28 adults whose cancer has not responded to prior treatments will rece…

This study tests whether a microbiome therapy (like a fecal transplant) can safely reduce antibiotic-resistant bacteria living in the gut of hospitalized patients. About 40 adults who carry these superbugs will receive either the therapy or a placebo. The goal is to lower the amo…

This early-phase study tests a new treatment for children whose neuroblastoma or osteosarcoma has not responded to standard therapy or has returned. The approach combines specially grown immune cells (gamma delta T cells) from a healthy donor with several chemotherapy drugs and a…

This study aims to make opioid use disorder treatment more available in rural Georgia by connecting emergency room patients with medical toxicologists at the Georgia Poison Center through video calls. About 480 adults who come to the ER with opioid withdrawal, overdose, or seekin…

This study tests a precise type of radiation called proton therapy for men with high-risk prostate cancer that has spread to lymph nodes. The goal is to see if targeting the tumor and nearby lymph nodes causes fewer bowel and bladder side effects than standard radiation. About 30…

This early-phase study tests whether adding low-dose IL-2 to the immunotherapy drug pembrolizumab can strengthen the immune system's attack on advanced lung cancer. About 15 people with untreated stage IV non-small cell lung cancer will receive the combination. The main goal is t…

This study tests whether giving a combination of three chemotherapy drugs (gemcitabine, cisplatin, and nab-paclitaxel) before surgery can help shrink pancreatic tumors and improve outcomes. It is for people with pancreatic cancer that can be removed or is borderline removable. Th…

This study tests whether adding diclofenac, a common anti-inflammatory painkiller, can help control tumor growth in people with advanced lung cancer whose disease is starting to worsen on immunotherapy alone. About 20 adults with stage III or IV non-small cell lung cancer will re…

This study tests whether a treatment made from healthy gut bacteria (microbiota therapy) can safely reduce the amount of drug-resistant germs living in the gut. About 60 adults who carry these superbugs will either get the treatment or be observed. The goal is to see if the thera…

This early-stage study tests whether infusions of special cells from donated umbilical cords (neonatal mesenchymal cells) are safe for people aged 4 to 29 with dilated cardiomyopathy, a condition where the heart is enlarged and weak. The goal is to see if these cells can improve …

This study is for people with advanced melanoma that has spread or cannot be removed by surgery. It tests whether giving two immunotherapy drugs (ipilimumab and nivolumab) in the morning works better than giving them later in the day. The goal is to see if timing can improve how …

This early-phase study tests a combination of two drugs—cabozantinib and enfortumab vedotin—in people with advanced bladder cancer that has spread or cannot be removed. The goal is to find the best dose and see if the combo is safe and shrinks tumors. About 32 adults who have alr…

This study is testing whether a quick, non-invasive eye-tracking test can help screen for autism spectrum disorder (ASD) and other developmental delays in babies as young as 9 months old. Researchers will use a mobile device to measure how infants look at social scenes, then foll…

This study tests whether playing online games with others can reduce loneliness and improve social connections in older adults, including those with mild cognitive impairment (MCI). Researchers will measure changes in feelings of isolation, loneliness, and quality of life. The go…

This study tests whether L-DOPA, a drug used for Parkinson's disease, can improve loss of interest and pleasure (anhedonia) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will m…

This study compares a pain management plan that avoids opioids to one that includes them, for people having joint replacement or other orthopedic surgeries. About 80 adults will be randomly assigned to one of two groups and report their pain levels for 14 days after surgery. The …

This study tests a 12-week sleep improvement program for adults aged 18-40 with type 1 diabetes. The goal is to see if better sleep helps with blood sugar control and reduces diabetes-related distress. 300 participants will be followed for 9 months.

This study looks at whether releasing a small chest muscle (pectoralis minor) during reverse shoulder replacement helps reduce pain and improve movement. About 90 adults getting this surgery will be randomly assigned to have the muscle released or not. Researchers will track pain…

This study tests a program called CARE-D-Foot-Nav, which assigns a patient navigator to help adults with diabetes and foot ulcers manage their care. The goal is to see if this extra support leads to more ulcers healing completely within 20 weeks compared to usual care. The study …

This study tests whether baricitinib, a drug that blocks JAK signaling, can improve motivation and brain function in people with major depression who have high inflammation. About 100 adults aged 25-55 with depression and elevated C-reactive protein will receive the drug or place…

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and uses heart rate biofeedback to help manage stress. About 128 teens aged 13-18 will either join the program right away or be placed on a waitlist. The goal is to see…

This study tests whether body-focused and non-body-focused interventions can reduce symptoms of dissociation in people who have experienced trauma. Researchers will enroll 350 participants at Emory University and the University of Pittsburgh. They will measure changes in brain ne…

This study tests a web-based rehab program for stroke survivors and their care partners (family members). The program focuses on problem-solving and arm exercises at home to improve the survivor's arm use and social participation while also supporting the caregiver's well-being. …

This study compares giving the chemotherapy drug oxaliplatin over 2 hours versus 6 hours to see if the longer infusion reduces nerve damage. About 60 people with gastrointestinal cancers who are scheduled for at least 4 cycles of FOLFOX6 chemotherapy will participate. The goal is…

This study tests a program called TRACT that helps cancer patients find transportation to their radiation treatments. Many patients miss or delay care due to travel problems, which can affect their health. The program will be offered to 76 adults with solid tumors who are getting…

This study tests whether a single dose of MDMA, given alongside two weeks of intensive exposure therapy, can help adults with PTSD feel better faster and longer. About 200 participants will receive either MDMA or a placebo during therapy. The main goal is to see if the combinatio…

This study tests if a safe, non-invasive brain stimulation technique called tDCS can reduce chronic pain in military veterans. About 100 veterans receiving care at Emory Healthcare will use a headset at home to deliver mild electrical currents to the brain. The goal is to see if …

This study tests whether a 6-day low-dose steroid (Medrol Dosepak) can reduce pain, nausea, and the need for opioid painkillers in 180 adults having foot or ankle surgery. Participants will report their pain and nausea levels, and researchers will track how many opioids they use.…

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce chronic nerve pain in people with HIV. Researchers will enroll 60 adults with HIV and neuropathic pain to take the drug for 12 weeks and report their pain levels. The goal is to …

This study tests whether exercising to beat-accented music helps older adults with memory concerns stay active and improve thinking skills. Eighty participants aged 65+ will do strength and aerobic training for 6 months, some with music and some without. Researchers will track ph…

This study compares two numbing medications, EXPAREL and bupivacaine, injected near the nerves around the ankle before total ankle replacement surgery. The goal is to see which provides better pain control and reduces the need for opioid painkillers afterward. About 104 adults ha…

This study looks at how different ways of giving voice therapy affect speaking ability over 12 months. It includes 120 adults with voice problems like muscle tension dysphonia or vocal fold lesions. Participants will receive behavioral voice therapy and be monitored through surve…

This early-stage study tests whether giving palliative radiotherapy together with the drug lurbinectedin is safe for people with extensive-stage small cell lung cancer that has spread beyond the chest. The goal is to relieve symptoms caused by the cancer. About 22 adults whose ca…

This study tests a web-based program for colorectal cancer patients on chemotherapy and their caregivers. The program targets common symptoms like fatigue, depression, sleep problems, pain, and brain fog. Researchers want to see if it's easy to use and helps improve quality of li…

This study tests whether a 12-week virtual physical therapy program is practical and helpful for children and young adults (ages 8-23) who are at least 100 days past a bone marrow transplant. Participants will have twice-weekly online sessions with a physical therapist and receiv…

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and high blood pressure, while still preventing brain swelling. About 200 adults with certain brain tumors will be enrolled. T…

This study looks at whether giving extra doses of a steroid called dexamethasone after scoliosis surgery can help teens recover better. About 50 participants aged 10-18 will either get the standard one dose or three extra doses after surgery. Researchers will measure pain, nausea…

This study looks at whether mindfulness training can improve recovery for college athletes who need surgery for sports injuries. About 40 student-athletes will either get mindfulness training or standard care. Researchers will track pain, physical function, and mental health for …

This study looks at how mental stress impacts the heart and blood vessels in postmenopausal women with coronary microvascular dysfunction (CMD), a condition where the heart's tiny arteries don't work properly, causing chest pain. Researchers will compare stress responses in women…

This study aims to find out how much protein adults with Phenylketonuria (PKU) need, based on their genetics and the special medical foods they eat. Researchers will measure how the body processes a harmless tracer in 18 participants. The goal is to better understand protein need…

This study looks at how the antibiotic doxycycline affects inflammation and the natural bacteria living in the body. Researchers will study 200 people with HIV or on HIV prevention medication (PrEP). The goal is to understand if doxycycline has extra effects beyond fighting infec…

This study looks at why people with PTSD often have higher heart disease risk. Researchers will test two daily therapies—deep breathing exercises and a mild nerve-stimulating device—to see if they can calm an overactive nervous system. About 120 veterans with or without PTSD and …

This study tests a new program called Compassion-Centered Spiritual Health Interventions for Teams (CCSH-TI) for hospital staff and providers. About 80 employees from a cancer center will be randomly assigned to either the program or their usual routine. The goal is to see if the…

This study explores a non-invasive way to weaken fear memories soon after a traumatic event, potentially lowering the risk of developing PTSD. Researchers will use brain imaging and mild sensory stimulation in 66 adults (some with PTSD) to see if they can disrupt how the brain st…

This study looks at whether a family history screening program can help more women in rural Georgia get tested for BRCA gene mutations linked to breast and ovarian cancer. About 3,200 women from public health clinics will take part. The goal is to see if the program increases the…

This study follows children under 21 who have a genetic condition that raises their risk of developing cancer, along with their relatives. Researchers will collect medical information and samples over time to better understand how these cancers develop and how to spot them early.…

This study is testing a new, non-invasive wearable patch with a microphone that listens to swallowing sounds in people who have trouble swallowing after a stroke. Researchers will collect these sounds during a standard swallowing X-ray test and use machine learning to find patter…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce suicidal thoughts and improve quality of life. About 130 English-speaking adults with bip…

This study compares a standard survivorship care plan to one that is simplified for people with lower health literacy. Researchers want to see if the tailored plan helps African American prostate cancer patients better understand their treatment side effects and follow-up needs. …

This study tests a group program called Weyera to see if it helps Ethiopian and Eritrean young adults (ages 18-29) in Atlanta build resilience and improve mental health. Researchers want to know if the program is acceptable, safe, and practical to run. The study will track how ma…

This study looks at how cancer patients and their doctors discuss immunotherapy. Researchers want to understand where patients get information, what they know, and how doctors explain the treatment. They will also test if educational videos can improve patient understanding. The …

This study looks at how the immune system responds in people with early-stage triple negative breast cancer who are receiving standard chemotherapy combined with immunotherapy (pembrolizumab). Researchers will measure certain immune markers in the blood and tumor tissue to see if…

This study looks at muscle scarring in the esophagus of people with achalasia, a swallowing disorder. Researchers want to see how scarring relates to muscle function tests. The goal is to understand the disease better so doctors can treat it earlier. About 80 adults with achalasi…

This study looks at whether combining prism adaptation training with electrical stimulation can help people who have had a stroke and have spatial neglect (trouble noticing things on one side). Researchers will measure changes in pointing, brain activity, and walking. The study i…

This study compares two different screening methods for PTSD in 804 pregnant Black women. The goal is to see which approach better identifies PTSD symptoms, improves use of prenatal and mental health care, and leads to healthier births. Participants will be in their first trimest…

This study tests whether a special type of MRI (spectroscopic MRI) can help doctors better target proton radiation therapy for children with aggressive brain tumors. The MRI maps tumor metabolism without needing a contrast injection. Researchers will check if this approach improv…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure spikes during activity. Researchers will test if regular bike exercise, a drug called Kuvan, or amino acid supplements can help. The goal is to understand the bod…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and pH levels in 110 veterans with and without CKD. The goal is to understand the body's response, n…

This study intentionally gives healthy adults a mild flu infection to learn how the immune system fights the virus and how the virus spreads. Researchers will monitor symptoms and safety closely. The goal is to gather knowledge, not to test a treatment or vaccine.

This study collects information from 735 Alzheimer's patients aged 50-90 who are receiving FDA-approved anti-amyloid antibody treatments. Researchers will track changes in memory, thinking, and daily living skills over time. The goal is to understand how well these drugs work in …

This study looks at why people with PTSD have a higher chance of heart disease and high blood pressure. Researchers want to understand what causes high adrenaline levels during stress in PTSD patients. They will also test if a medicine called losartan can lower these adrenaline l…

This study looks at how the amount of muscle and fat in the body affects health in people with cystic fibrosis (CF) aged 16 to 30. Researchers will measure body fat distribution, lung function, and blood sugar control in 60 people with CF and 30 healthy volunteers. The goal is to…