ULCERATIVE COLITIS

This study observed 152 adults in France with moderate-to-severe ulcerative colitis who were prescribed the drug tofacitinib by their doctor. It aimed to see how well the medication controlled their symptoms and improved their quality of life over two years of regular use. The go…

This study tested whether the drug mirikizumab could help people with moderate to severe ulcerative colitis maintain their improvement after initial treatment. Over 1,100 participants who had responded well to an earlier 12-week treatment phase received either mirikizumab or a pl…

This study followed 877 people with moderate to severe ulcerative colitis to see how safe and effective the oral medication RPC1063 is over the long term. Only people who had already been in previous RPC1063 trials could join this extension study. The main goal was to monitor sid…

This study tested whether using a blood protein test to identify patients with inflammatory bowel disease (IBD) at high risk for severe disease could improve their outcomes. Newly diagnosed patients were randomly assigned to either have their treatment guided by this test or rece…

This study tested a new daily pill called ABX464 for people with moderate-to-severe ulcerative colitis who didn't get better on standard treatments. Researchers compared three different doses of the pill against a placebo in 355 patients over 16 weeks to see if it safely reduced …

This study tested a new skin patch designed to deliver the drug ozanimod, which is used for multiple sclerosis and ulcerative colitis. Researchers compared how the body absorbs the drug from three different patch formulas versus the standard oral capsule. The goal was to see if t…

This study tested whether a daily oral medication called amiselimod could help control symptoms and reduce intestinal inflammation in adults with mild to moderate ulcerative colitis. For the first 12 weeks, 322 participants were randomly assigned to receive either the real drug o…

This study tested whether taking probiotics could help patients with ulcerative colitis stay in remission and control their disease. Researchers followed 70 Egyptian adults whose colitis was already in a quiet phase. They measured symptoms and gut bacteria over one year to see if…

This study tested whether a guided physical activity program could help improve bone mineral density in children and teenagers with chronic inflammatory bowel diseases like Crohn's disease and ulcerative colitis. It involved 15 young participants who followed the exercise program…

This study tested whether a web-based monitoring system could help people with complex inflammatory bowel disease (like Crohn's or colitis) stay in remission as well as standard clinic visits. 290 adults in Spain who were already taking strong medications for their condition were…

This study tested whether a daily pill called ABX464 could help people with moderate to severe ulcerative colitis who haven't responded well to other treatments. Researchers compared the pill against a placebo in 639 participants over 8 weeks to see if it could reduce symptoms an…

This study tested an experimental oral medication called ABBV-668 for adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. About 30 participants took capsules twice daily for 16 weeks to see if the drug could reduce intestinal inflammation and …

This small pilot study explored whether adding steamed broccoli sprouts to the diet could help manage mild ulcerative colitis. Researchers tested if eating the sprouts increased certain beneficial compounds in the body and reduced gut inflammation markers. The goal was to see if …

This study monitored 308 adults in Japan with moderate to severe ulcerative colitis who were prescribed Rinvoq by their doctors. The goal was to check the drug's safety and how well it controlled the disease in real-world, everyday medical practice. Participants were followed for…

This study monitored the long-term safety and effectiveness of the drug Entyvio (vedolizumab) in people with moderate to severe ulcerative colitis. It observed over 1,100 patients in Japan who were already receiving the drug as part of their regular care. The goal was to collect …

This early-stage study tested whether TUDCA, a dietary supplement, could help control ulcerative colitis symptoms. Fourteen adults with active ulcerative colitis took TUDCA for six weeks while researchers monitored safety and measured changes in gut inflammation. The goal was to …

This study tested whether rutin, a natural compound found in plants, could help people with ulcerative colitis. Researchers gave rutin to 60 adults with the condition to see if it could reduce gut inflammation and improve symptoms by calming a specific overactive part of the immu…

This study tested a daily pill called ABX464 to see if it could safely keep ulcerative colitis under control over a long period. It involved 217 people with moderate to severe disease who had already taken the drug in a previous short-term study. The main goal was to see how many…

This small, early-stage study tested the safety of a new treatment called MB310, which is made of specific live bacteria. It involved 29 adults with active, mild-to-moderate ulcerative colitis. The main goal was to see if the treatment was safe and if the bacteria could successfu…

This study tested whether a daily pill called ABX464 could help control moderate-to-severe ulcerative colitis in people who haven't gotten enough relief from standard treatments. Researchers compared the pill to a placebo (inactive pill) in 636 participants over 8 weeks to see if…

This study tested whether the drug Mirikizumab could help patients with moderate to severe ulcerative colitis who were not getting better on their current treatments. It specifically looked at patients who had a high level of inflammation seen during a colonoscopy. The goal was t…

This study tested if a special dietary fiber, called a prebiotic, could help control ulcerative colitis by improving gut bacteria and reducing symptoms. Thirty-eight adults with mild to moderate disease took the prebiotic or a placebo powder for four weeks each, and researchers m…

This study tested whether regularly checking the level of anti-TNF drugs in a patient's blood helps manage Crohn's disease and ulcerative colitis more effectively. 260 patients were split into two groups: one where doctors used these blood test results to adjust treatment, and on…

This study looked at whether switching patients with stable Crohn's disease or ulcerative colitis from receiving their infliximab medicine through an IV at a clinic to giving themselves a shot at home was effective. It followed 38 adult patients for 24 weeks after the switch to s…

This study monitored Korean adults with moderate to severe ulcerative colitis or Crohn's disease who were prescribed the approved drug upadacitinib (RINVOQ) by their doctor. The goal was to collect real-world information on the drug's safety and how well it controls disease sympt…

This study checked the long-term safety and effectiveness of the drug adalimumab in children and teenagers with ulcerative colitis (UC). It involved 59 young patients who had already taken the drug in a previous trial. The main goal was to see if continued use was safe and if it …

This study aimed to understand the long-term safety of a medication called vedolizumab in children and teenagers with ulcerative colitis or Crohn's disease. It followed 59 young participants who had already responded to the drug in a previous trial, monitoring them for side effec…

This study compared two standard colonoscopy techniques used to screen for colon cancer in people who have had inflammatory bowel disease (IBD) for eight years or more. Researchers tested whether high-definition white-light colonoscopy works as well as dye-spraying colonoscopy at…

This study aimed to see if simple ratios calculated from routine blood tests could help doctors monitor how active ulcerative colitis is in a patient. Researchers compared these blood test results against colonoscopy findings, which is the standard way to check disease activity, …

This study looked at whether switching patients to a higher concentration version of the drug adalimumab (brand name SIMLANDI™) causes less injection site pain than the standard version. It involved 324 Canadian adults with conditions like Crohn's disease, rheumatoid arthritis, o…

This study tested whether a special plant-based, low-calorie 'fasting mimicking' diet could reduce depression symptoms in people with Crohn's disease or ulcerative colitis. 42 adult participants with mild depression tried three cycles of the 5-day diet, followed by normal eating.…

This study tested whether eating a gluten-free diet could reduce gut symptoms and fatigue in people with ulcerative colitis. Fifteen participants tried two different diets for one week each: one with high gluten and one completely gluten-free. Researchers measured their symptoms …

This small, exploratory study tested a single session using a virtual reality app with an AI-powered guide to provide mental health support. It involved 22 adults with inflammatory bowel disease (IBD) who also had mild to moderate anxiety or depression. The main goal was to see i…

This study tested a new self-management program designed to help people with Crohn's disease or ulcerative colitis. The program taught 55 participants strategies for tracking symptoms, managing stress and pain, improving sleep, and adjusting diet. Researchers wanted to see if the…

This was an early safety study of an oral medication called MB-001, which is being developed for ulcerative colitis. The trial tested the drug in 48 healthy volunteers to see if it was safe and how the body processed it. Participants received either the drug or a placebo (a dummy…

This study observed patients in Poland with Crohn's disease or ulcerative colitis who were already taking the medication vedolizumab. Researchers tracked whether patients continued their treatment, switched how they received it (from IV infusion to under-the-skin injection), or s…

This study aimed to understand why inflammatory bowel diseases (IBD) like Crohn's and colitis are often more severe in children. Researchers tested the idea that DNA leaking from cells might trigger and worsen gut inflammation through a specific biological pathway. They analyzed …