ULCERATIVE COLITIS

This study tested a new drug called ABX464 in 639 people with moderate to severe ulcerative colitis who had not responded well to other treatments. Participants took either 25 mg, 50 mg, or a placebo pill once daily for 8 weeks. The main goal was to see if the drug could help ach…

This study followed 152 adults with moderate to severe ulcerative colitis for two years to see how well tofacitinib works in real-life medical practice. Researchers measured symptom improvement and whether patients could avoid surgery or stronger medications. The goal was to unde…

This study tested the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It involved 877 participants who had already been in earlier trials of the same drug. The goal was to see how well the drug control…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis that hasn't responded to standard treatments. 100 adults took part. Researchers looked for improvements in symptoms, colon healing, and tissue health. The goal was to see if mirikizum…

This study tested an experimental drug called ABBV-668 in about 30 adults with moderate to severe ulcerative colitis, a condition causing inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks. The goal was to see if it could improve colon hea…

This study tested an experimental daily pill called ABX464 in 355 adults with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could reduce symptoms like diarrhea, bleeding, and colon inflammation compared to a …

This study tested whether a blood test measuring proteins can help doctors choose a more powerful treatment early for people newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 300 patients were split into two groups: one where…

This study tested whether rutin, a natural plant compound, can reduce inflammation and improve symptoms in people with ulcerative colitis. Sixty adults with confirmed UC took rutin, and researchers measured changes in their symptoms and gut inflammation markers. The goal was to s…

This study looked at how safe and effective upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 600 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to track an…

This pilot study tested whether eating steamed broccoli sprouts could increase levels of a natural compound called sulforaphane in the body and reduce inflammation in people with mild ulcerative colitis. 23 participants were asked to add broccoli sprouts to their diet for a short…

This study tested a web-based telemonitoring system called TECCU for people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis). 290 adults who were starting new treatments were randomly assigned to use the TECCU system or receive usual care…

This study looked at the long-term safety of the drug vedolizumab in children aged 2 to 17 with ulcerative colitis or Crohn's disease. 59 children who had already responded to the drug in an earlier study continued treatment. The main goal was to track any side effects over time.

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it settles in the gut. Participants received either MB310 or a placebo, and researchers monitored side effects and…

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic gut condition. 85 adults received four treatments through a tube and enema. The goal was to see if donor bacteria could reduce inflammation and improve symptoms li…

This study looked at how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis (UC), a chronic inflammatory bowel disease. About 300 participants in Japan took Rinvoq as prescribed by their doctor and were followed for up to 60 weeks. The mai…

This study tested a drug called mirikizumab to see if it can help people with moderate to severe ulcerative colitis stay in remission. About 1,300 adults who improved during an earlier treatment phase took either mirikizumab or a placebo for 40 weeks. The goal was to check if the…

This study looked at over 1,100 people with moderate to severe ulcerative colitis who were given Entyvio (vedolizumab) as part of their regular care. The goal was to see how safe and effective the drug is over the long term. Researchers tracked side effects and how well patients …

This study looked at 38 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) whose disease was under control with intravenous infliximab. Researchers switched them to a subcutaneous (under-the-skin) version to see if drug exposure, effectiveness, and quality of …

This study tested a new daily medication, ABX464, in 636 people with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help achieve remission (symptom relief and healing of the colon) after 8 weeks. The stu…

This study tested the long-term safety of adalimumab (a drug that blocks inflammation) in 59 children with ulcerative colitis who had already completed a previous study. Researchers tracked side effects and how well the drug controlled disease symptoms using standard scoring tool…

This study looked at whether probiotics (good bacteria) could help people with ulcerative colitis stay in remission. Researchers followed 70 Egyptian adults for one year, checking their disease activity, body mass index, and gut bacteria. The goal was to see if changing the gut m…

This study tested a daily pill called ABX464 in 217 adults with moderate to severe ulcerative colitis who had already completed 16 weeks of treatment. The goal was to see if the drug could keep the disease in remission for up to 96 weeks. The approach focuses on controlling the d…

This study tested an oral medication called amiselimod (MT-1303) in 322 adults with mild to moderate ulcerative colitis. Participants received either the drug or a placebo for 12 weeks to see if it improved symptoms like diarrhea and rectal bleeding, followed by an open-label per…

This early-phase study tested whether TUDCA, a bile acid supplement, is safe and can reduce cell stress in the colon of people with active ulcerative colitis. Fourteen adults with mild to moderate disease took TUDCA for 6 weeks. Researchers measured stress markers in colon tissue…

This study looked at whether a short-term, plant-based low-calorie diet (called a fasting mimicking diet) could improve depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with IBD and mild-to-moderate depression completed three 5-day diet cycles. Resea…

This small study tested whether an AI-powered virtual reality app could safely help people with inflammatory bowel disease (IBD) who also have mild to moderate anxiety or depression. Twenty-two adults with IBD used the app during a single session. The goal was to see if the appro…

This study looked at whether a tailored physical activity program could help children and teens with inflammatory bowel disease (IBD) improve their bone density. Kids with IBD often have weaker bones due to inflammation, medication, and low activity levels. Fifteen participants c…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration adalimumab injection. Researchers measured injection site pain and how well patients stuck with the new treatment over 180 days. The…

This study looked at whether eating gluten-free for one week can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults with the condition ate a gluten-free diet plus special granola bars—first without gluten, then with high gluten. They reported …

This study tested whether a prebiotic (a type of fiber that feeds good gut bacteria) can improve symptoms in people with mild to moderate ulcerative colitis. 38 adults took either the prebiotic or a placebo for four weeks, then switched. Researchers measured symptom changes, gut …

This study tested a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Researchers wanted to …

This study observed 165 people with inflammatory bowel disease (IBD) in Poland who were taking vedolizumab either as an IV infusion or a subcutaneous injection. Researchers tracked how long patients stayed on their treatment, why some switched or stopped, and what other treatment…

This study tested a new skin patch (transdermal delivery system) for the drug ozanimod, which is used to treat multiple sclerosis and ulcerative colitis. Researchers wanted to see how well the drug is absorbed through the skin compared to taking it as an oral capsule. Twenty-four…

This early-stage study tested whether the oral biologic MB-001 is safe in 48 healthy adults aged 18 to 65. Participants received either a single dose or five daily doses of the drug or a placebo, and were monitored for side effects. The study is complete, and results will help de…

This study looked at how having inflammatory bowel disease (Crohn's or ulcerative colitis) as a child affects work and education in adulthood. Researchers surveyed 343 adults who were diagnosed before age 17 to compare their employment and schooling with the general population. T…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least 8 years and were getting a routine screening. The …

This study explored whether inexpensive, widely available blood tests can help doctors track disease activity in people with ulcerative colitis. Researchers compared these blood markers with standard colonoscopy and stool tests in 80 patients. The goal was to find simpler ways to…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (IBD) to understand how DNA that escapes from cells might worsen inflammation. Researchers analyzed blood, stool, and gut tissue samples to study a specific pathway called cGAS-STING. The goal was to id…

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to compare infection risks from three types of advanced treatments: ENTYVIO, TNF-alpha inhibitors, and ustekinumab. Researchers used existing Medicare claims data from 2016 to 2025 to…

This study looked at whether regularly measuring the amount of anti-TNF medication and antibodies in the blood helps doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. 260 patients were split into two groups: one where doctors had acces…