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Fasting diet shows promise for depression in bowel disease

NCT ID NCT05382897

Symptom relief Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a low-calorie, plant-based diet that mimics fasting could reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD followed either the fasting-mimicking diet or a calorie-sufficient plant-based diet for three 5-day cycles over three months. Researchers measured changes in mood, gut microbes, and immune function to see if targeting the gut could improve mental health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
plant-based fasting-mimicking diet
What this could lead to
If it works, this could offer a safe, non-drug way to improve mood in people with inflammatory bowel disease.
What could go wrong
This was a small, early-stage trial with only 42 participants. The diet is restrictive and may be hard to follow long-term. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Jul 2022

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 and ≤ 65 years at the time of screening * Diagnosis of Crohn's disease in clinical remission or with mild-moderate disease with Harvey Bradshaw Index (HBI\<8) or diagnosis of ulcerative colitis in clinical remission with partial Mayo (pMayo\<7) * Suffering from mild-moderate depression with PHQ-9 ≥5 and ≤ 19 Exclusion Criteria: * Subjects who are reliant on partial or total parenteral nutrition * Subjects with prior gastrointestinal surgery and consequences such as short bowel syndrome, ostomy of small or large intestine, total colectomy, proctocolectomy, or ileoanal pouch * Subjects with diabetes or celiac disease * Subjects with a body mass index (BMI) lower than 18 * Subjects suffering from malnutrition or at high risk of malnutrition assessed by a score of ≥6 on the abridged patient generated subjective global assessment (PGSGA) * Subjects allergic to nuts * Subjects currently on a fasting/intermittent type caloric restricted diet * History of psychotic or bipolar disorders or experiencing suicidal thoughts * Pregnant women, women who are breast feeding, or women planning on becoming pregnant * Subjects with immune-compromised condition other than inflammatory bowel disease (e.g. AIDS, lymphoma) * Subjects with severe uncontrolled cardiovascular or respiratory disease or active malignancy * Unable to read English or provide informed consent

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Conditions

The condition(s) this trial relates to.

Crohn disease Depression Fasting inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crohn disease Inflammatory bowel diseases Ulcerative colitis

Contacts and locations

Locations

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2E1, Canada

  • University of Alberta Human Nutrition Research Unit

    Edmonton, Alberta, T6G 2E1, Canada

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