ULCERATIVE COLITIS

This study tests a device that filters inflammatory substances from the blood during flare-ups of Crohn's disease or ulcerative colitis. About 40 adults will either receive standard care alone or standard care plus the Efferon LPS filter. The goal is to see if the filter safely r…

This study tests whether adding acupuncture to the standard drug mesalazine helps people with mild-to-moderate ulcerative colitis achieve and maintain remission. About 80 adults will receive either the combination therapy or mesalazine alone. The goal is to see if the integrated …

This study tests a steroid foam (budesonide) given rectally to children aged 5 to 17 with mild to moderate ulcerative colitis in the lower colon. The goal is to see if it can safely put the disease into remission. About 100 children will receive either a low or high dose of the f…

This study will test if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) helps people with over 30 different conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. About 100 participants will receive the treatment and repor…

This study tests a new diet designed to meet the protein needs of people with ulcerative colitis while reducing harmful gas (hydrogen sulfide) made by gut bacteria. Researchers will measure gas levels in stool samples from 40 adults with mild to moderate disease. The goal is to s…

This study tests a new drug called ATH-063 in people with moderate to severe ulcerative colitis who have not improved with other advanced treatments. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding and help the gut heal. About 120 adults will receive…

This study tests whether Aquamin®, a natural mineral supplement, can prevent pouchitis—inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take the supplement or a placebo for up to 8 months. The goal is to se…

This study tests a one-day acceptance and commitment therapy (ACT) program designed for veterans with inflammatory bowel disease (IBD) and mental health conditions like depression or anxiety. The goal is to see if this brief therapy is practical and helpful for improving quality …

This study tests a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal is to see if changing behaviors can improve health and quality of life. About 40 adults with active IBD will take part in the pr…

This study tests whether a 5-week heart rate variability biofeedback program can reduce symptoms like belly pain and urgency in 23 adults with mild-to-moderate ulcerative colitis. Participants will learn breathing techniques to improve heart rate patterns, and researchers will tr…

This study tests whether a special sleep therapy (CBT-I) delivered over video calls can help adults with ulcerative colitis who also have insomnia. About 20 people will take part in 5 therapy sessions and complete online sleep diaries and questionnaires. The goal is to see if the…

This study looks at whether changes in bile acids (digestive fluids) in children with ulcerative colitis make them more likely to get a serious gut infection called C. difficile. Researchers will compare bile acid and gut bacteria patterns in 80 children: those with active coliti…

This study follows about 1,200 pregnant women with ulcerative colitis who take the drug ozanimod. Researchers will track the health of mothers and babies, looking for birth defects and other problems. The goal is to learn whether the drug is safe to use during pregnancy.

This study follows 50 adults with active ulcerative colitis who are already seeing a naturopathic doctor. Over 12 weeks, researchers track symptom changes using questionnaires. The goal is to gather early information on how naturopathic care may help manage UC symptoms, without c…

This study is developing a questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will interview 275 patients to identify key self-care behaviors, then test the questionnaire's accuracy. The goal is to give doctors a be…